RecruitingNot ApplicableNCT07599657

Surfactant Protein D Levels in GCF Before and After MINST in Periodontitis

Evaluation of Surfactant Protein D (SP-D) Levels in the GCF of Periodontitis Patients Associated With the Endpoints After Minimally Invasive Non-surgical Periodontal Therapy: A Before and After Study

Sponsor

Cairo University

Enrollment

18 participants

Start Date

May 14, 2026

Study Type

INTERVENTIONAL

Conditions

Periodontitis Periodontitis Stage II Periodontitis Stage III

Summary

This study will evaluate changes in Surfactant Protein D (SP-D) levels in gingival crevicular fluid (GCF) of patients with periodontitis before and after minimally invasive non-surgical periodontal therapy (MINST). Participants diagnosed with stage II or III periodontitis will receive minimally invasive non-surgical periodontal treatment. GCF samples will be collected at baseline and 6 months after treatment, and SP-D levels will be measured using enzyme-linked immunosorbent assay (ELISA). The study will also assess clinical periodontal outcomes, including full-mouth plaque score, full-mouth bleeding score, probing pocket depth, clinical attachment level, gingival recession, and patient satisfaction. Each participant will serve as their own control by comparing baseline values with 6-month post-treatment values.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Male and female participants aged 18 years or older.
Diagnosis of periodontitis, classified as stage II or stage III according to the 2018 classification system.
Presence of at least one tooth with probing pocket depth (PPD) of 5 mm or more, clinical attachment loss (CAL), and radiographic evidence of bone loss.
Presence of at least one intrabony defect with a radiographic intrabony component measuring 3 mm or more.

Exclusion Criteria4

Current smokers or individuals with a history of smoking within the past year.
Pregnant or lactating women.
Use of systemic antibiotics or anti-inflammatory medications within the last 3 months.
Known allergy to any materials or agents used during periodontal therapy.

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Interventions

PROCEDUREMinimally Invasive Non-Surgical Periodontal Therapy

Minimally invasive non-surgical periodontal therapy will include oral hygiene instructions, supragingival plaque control, and subgingival instrumentation using fine periodontal instruments, miniature Gracey curettes, thin ultrasonic tips, magnification when available, and local anesthesia when needed. Debridement will be performed for periodontal pockets while minimizing trauma to the soft tissues.