The Effect of Remimazolam Versus Propofol on Postoperative Extubation Time
The Effect of Remimazolam Versus Propofol on Postoperative Extubation Time in Patients Undergoing Laparoscopic Hepatectomy: A Randomized Controlled Trial
Xuyu Zhang
82 participants
Dec 1, 2025
INTERVENTIONAL
Conditions
Summary
This clinical trial aims to help us understand how two drugs, Propofol and Remazoloam, affect when researchers remove a Participants' breathing tube after liver surgery (laparoscopic liver resection).The main research questions include: comparing the time to breathing tube removal between patients who receive each drug, comparing changes in heart rate and blood pressure during surgery, and comparing the rates of unwanted medical events after surgery. Researchers will give either Propofol or Remimazolam as a sedative medicine for anesthesia. This will allow the researchers to compare the time to breathing tube removal after surgery. Participants will complete their surgery according to a pre-planned surgical plan.
Eligibility
Inclusion Criteria5
- : Planned to undergo laparoscopic hepatectomy.
- : Has signed the informed consent form.
- : Aged 18 to 80 years.
- : Body Mass Index (BMI) ranging from 18 to 28 kg/m².
- : American Society of Anesthesiologists (ASA) physical status classification I to III.
Exclusion Criteria4
- ）: Severe cardiopulmonary dysfunction, or hepatic/renal dysfunction.
- ）: Diagnosis of neuropsychiatric disorders.
- ）: Pregnant or lactating women.
- ）: A history of allergy or contraindication to benzodiazepines, propofol, or any of their components.
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Interventions
Anesthesia induction: Intravenous injection of remimazolam 0.2-0.4 mg/kg. Anesthesia maintenance: Continuous infusion of remimazolam at 0.4-0.7mg/kg/h.
Anesthesia induction: Intravenous injection of propofol 1.5-2.5 mg/kg. Anesthesia maintenance: Continuous infusion of propofol at 4-10 mg/kg/h.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07611344