RecruitingNot ApplicableNCT07632664

Clinical Study of a New Treatment Model for Elderly Lung Cancer Patients

A Multicenter Clinical Study on a New Treatment Model Combining New Surgical Techniques, Perioperative Comprehensive Treatment, and Postoperative Rehabilitation for Elderly Patients With Lung Cancer

Sponsor

Peking University People's Hospital

Enrollment

1,000 participants

Start Date

Aug 1, 2024

Study Type

INTERVENTIONAL

Conditions

Lung Neoplasm Perioperative Care Aged Postoperative Rehabilitation Thoracic Surgical Procedures

Summary

This multicenter prospective clinical study focuses on elderly patients with lung cancer. The investigators will build a standardized clinical registry database, develop perioperative risk stratification and surgical early-warning models, optimize individualized surgical regimens, construct multidisciplinary perioperative comprehensive therapy, integrated Chinese-Western medicine full-cycle management and personalized postoperative rehabilitation systems, so as to form a whole-process optimized treatment model for elderly lung cancer.

Eligibility

Min Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a procedure called Pulmonary Lobectomy plus Mediastinal Lymph Node Sampling, a procedure called Pulmonary Segmentectomy plus Mediastinal Lymph Node Sampling, and others for people with aged, lung neoplasm, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 65 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREPulmonary Lobectomy plus Mediastinal Lymph Node Sampling

Standard anatomical lobectomy combined with systematic mediastinal lymph node sampling for early-stage T1N0M0 non-small cell lung cancer in patients aged ≥65 years; postoperative stratified adaptive perioperative management guided by MRD and tumor biomarkers.

PROCEDUREPulmonary Segmentectomy plus Mediastinal Lymph Node Sampling

Curative segmentectomy with mediastinal lymph node sampling after preoperative comprehensive geriatric risk assessment (CGA, VES-13, ASA grading); postoperative personalized perioperative treatment stratified by postoperative minimal residual disease status.

PROCEDUREPulmonary Wedge Resection plus Mediastinal Lymph Node Sampling

Wedge resection plus mediastinal lymph node sampling for eligible elderly early lung cancer patients; low-risk subjects receive de-escalated adaptive perioperative treatment, while high-risk patients receive intensified comprehensive therapy based on postoperative risk stratification.