RecruitingNot ApplicableNCT07632755

Validation of a Remediation Method for Memory Impairments Through Motor Encoding in Patients With Alzheimer's Disease

Sponsor

Centre Hospitalier Universitaire de Saint Etienne

Enrollment

80 participants

Start Date

Jul 15, 2026

Study Type

INTERVENTIONAL

Conditions

Healhty Alzheimer s Disease

Summary

In France, over 1.5 million people suffer from mild cognitive impairment, often a precursor to Alzheimer's disease (AD), whose global prevalence could reach 153 million by 2050. With no curative treatment available, maintaining patients' autonomy at home is essential to mitigate the negative effects of institutionalization and reduce economic costs. Non-pharmacological approaches, such as cognitive training, have shown potential in stabilizing cognitive functions. Research suggests that motor networks and procedural memory remain relatively preserved in early AD, and bodily engagement during encoding enhances memory. For patients with motor impairments, motor imagery (MI) activates these networks without actual movement. Additionally, dynamic visual cues, like videos, reduce cognitive load compared to static images. This project aims to combine real action, MI, and dynamic visual supports to optimize memory. By validating 120 videos of daily activities, it will assess the impact of action on recall, evaluate MI's effectiveness for patients with mobility limitations, and confirm the superiority of videos over static images. The results could support the development of digital tools, such as serious games, to enhance patients' autonomy and address aging-related challenges.

Eligibility

Min Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a behavioral approach called Action execution, a behavioral approach called Control condition, and others for people with alzheimer s disease and healhty. The study is currently recruiting participants at 3 locations. People eligible for this study include aged 60 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALControl condition

Reading a sentence aloud and the participant is asked to freely recall, without delay and without cues, all the sentences presented in the block. The number of correctly recalled sentences is recorded.

BEHAVIORALMotor mental imagery

Following the reading of each sentence, the participant is instructed to mentally simulate performing the action described in the sentence. And the participant is asked to freely recall, without delay and without cues, all the sentences presented in the block. The number of correctly recalled sentences is recorded.

BEHAVIORALAction execution

After reading the sentence, the participant pantomimes the action described and The participant is asked to freely recall, without delay and without cues, all the sentences presented in the block. The number of correctly recalled sentences is recorded.