RecruitingNCT07640997

Real-world Study of Aflibercept 8 mg in nAMD

REFLECTION-An Observational Study Program to Investigate the Effectiveness of Aflibercept 8 mg Used in Neovascular Age-related Macular Degeneration (nAMD) in a Real-world Setting.

Sponsor

Peking University People's Hospital

Enrollment

300 participants

Start Date

Nov 11, 2025

Study Type

OBSERVATIONAL

Conditions

Neovascular Age-Related Macular Degeneration (nAMD)

Summary

The goal of this observational study is to explore the effectiveness of aflibercept 8 mg in treating both treatment-naive and previously treated patients with neovascular age-related macular degeneration (nAMD) in a real-world setting. The main questions it aims to answer are: What are the short-term and long-term efficacy outcomes of aflibercept 8 mg in treatment-naive or previously treated nAMD patients? What are the safety characteristics and the treatment patterns of aflibercept 8 mg in these patient populations? Participants will: Receive aflibercept 8 mg as part of their clinical treatment for nAMD. Undergo assessments to evaluate both the efficacy and safety of the treatment over the short and long term. Provide data on their visual acuity (BCVA) changes at multiple follow-up points (4 weeks, 8 weeks, 16 weeks, 6 months, and 12 months). Report any adverse events and treatment patterns during the study period. Have their central subfield thickness (CST) measured at specified intervals. This study will help inform clinical practices regarding the use of aflibercept in nAMD patients and contribute to understanding its effectiveness and safety in real-world settings.

Eligibility

Min Age: 50 Years

Inclusion Criteria4

Patient aged ≥50 years
A diagnosis of nAMD
Signed informed patient consent before the start of data collection
Patients for whom the decision to initiate treatment with IVT aflibercept 8 mg according to a local product information was made as part of routine clinical practice

Exclusion Criteria9

Participation in an investigational program with interventions outside of clinical routine practice
Contraindications as listed in the intravitreal aflibercept 8 mg local product information (Ocular or periocular infections, severe active intraocular inflammation, and known allergy to aflibercept or any of its excipients)
The fellow eye has received intravitreal anti-VEGF treatment other than aflibercept within 28 days prior to enrollment
Intraocular pressure (IOP) in the study eye > 25 mmHg
Any prior ocular treatment in the study eye or systemic treatment for nAMD
Prior intravitreal anti-VEGF treatments in the study eye within the last 28 days
Prior treatment with intravitreal corticosteroid in the study eye within the last 3 months
Dexamethasone implant in the study eye within the last 6 months
Any concurrent drug releasing implant in the study eye

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Interventions

DRUGAflibercept 8mg

Aflibercept 8mg, following the manner of observational study, no intervention will be provided in the study. Any treatment decision, including the decision for aflibercept 8 mg treatment, is at the discretion of the attending physician, made in accordance with his/her experience and follows approved clinical guidelines.