RecruitingPhase 2NCT07641517

A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain

Randomized, Placebo-Controlled, Phase 2 Clinical Trial to Evaluate LY4065967 for the Treatment of Osteoarthritis

Sponsor

Eli Lilly and Company

Enrollment

150 participants

Start Date

Jun 25, 2026

Study Type

INTERVENTIONAL

Conditions

Chronic Pain Osteoarthritis, Knee

Summary

The main purpose of this study is to test the safety and efficacy of study drug for the treatment of knee pain due to osteoarthritis (OA). This trial is part of the chronic pain master protocol H0P-MC-CPMP (NCT05986292), which is a protocol to accelerate the development of new treatments for chronic pain.

Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called LY4065967 and a drug called Placebo for people with chronic pain and osteoarthritis, knee. The study is currently recruiting participants at 37 locations. People eligible for this study include aged 40 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGLY4065967

Administered orally

DRUGPlacebo

Administered orally

Locations(37)

Central Research Associates

Birmingham, Alabama, United States

Synexus Clinical Research US, Inc.

Phoenix, Arizona, United States

Arizona Research Center

Phoenix, Arizona, United States

Desert Oasis Healthcare Medical Group

Palm Springs, California, United States

Artemis Institute for Clinical Research

Riverside, California, United States

Artemis Institute for Clinical Research

San Diego, California, United States

CMR of Greater New Haven

Hamden, Connecticut, United States

Bradenton Research Center, Inc.

Bradenton, Florida, United States

Accel Research Sites - DeLand Clinical Research Unit

DeLand, Florida, United States

K2 MEDICAL Research THE VILLAGES

Lady Lake, Florida, United States

K2 Medical Research ORLANDO

Maitland, Florida, United States

Merritt Island Medical Research, LLC

Merritt Island, Florida, United States

Suncoast Research Group

Miami, Florida, United States

New Horizon Research Center

Miami, Florida, United States

Suncoast Clinical Research, Inc.

New Port Richey, Florida, United States

Renstar Medical Research

Ocala, Florida, United States

Precision Clinical Research

Sunrise, Florida, United States

Charter Research - Lady Lake

The Villages, Florida, United States

Conquest Research

Winter Park, Florida, United States

North Georgia Clinical Research

Woodstock, Georgia, United States

Northwestern University

Chicago, Illinois, United States

DelRicht Research

New Orleans, Louisiana, United States

Lucida Clinical Trials

New Bedford, Massachusetts, United States

MedVadis Research Corporation

Waltham, Massachusetts, United States

Great Lakes Research Group, Inc.

Bay City, Michigan, United States

StudyMetrix Research

City of Saint Peters, Missouri, United States

Clinvest Research LLC

Springfield, Missouri, United States

Rochester Clinical Research, LLC

Rochester, New York, United States

Lillestol Research

Fargo, North Dakota, United States

META Medical Research Institute

Dayton, Ohio, United States

DelRicht Research

Tulsa, Oklahoma, United States

Altoona Center For Clinical Research

Duncansville, Pennsylvania, United States

FutureSearch Trials of Neurology

Austin, Texas, United States

Re:Cognition Health - Fort Worth

Fort Worth, Texas, United States

Northwest Clinical Research Center

Bellevue, Washington, United States

Rainier Clinical Research Center

Renton, Washington, United States

Ponce Medical School Foundation Inc.

Ponce, Puerto Rico

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT07641517

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