RecruitingNot ApplicableNCT07652333

The Effects of Strength Training on Muscle Mass and Mental Health in Adults Taking Obesity Medication

The Effects of Strength Training on Muscle Mass and Mental Health in Adults Taking Obesity Medication: A Pilot Study


Sponsor

University of Pittsburgh

Enrollment

40 participants

Start Date

May 25, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to examine the effects of resistance exercise, such as weightlifting, on retention of muscle mass and mental health in individuals taking GLP-1 RAs (an obesity medication). Resistance exercise is focused on increasing the strength of participants' muscles, such as how much participant can lift. •The duration of this study is 3 months. This includes: * Orientation session to explain study protocol, exercise program, and complete questionnaire about participants' medical history and lifestyle. * Two health assessments at baseline and at 3 months. These assessments include body composition, resting blood pressure, cardiovascular function, and muscular strength. Both the resistance exercise group and the control group will complete assessments at baseline and again at 3 months. After the 3-month period, individuals in the control group may choose to participate in the exercise training and complete the optional 6-month assessments. * Personalized resistance exercise sessions for 60 minutes per session, twice per week, for 3 months.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called GLP-1 RAs and a behavioral approach called Resistance Exercise for people with muscle composition, obesity, and other related conditions. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALResistance Exercise

60 min/session, all for 2 sessions/week for 12 weeks

DRUGGLP-1 RAs

Participants will take GLP-1 RAs for 12 weeks


Locations(1)

Physical Activity Research Center, University of Pittsburgh

Pittsburgh, Pennsylvania, United States

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NCT07652333


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