RecruitingPhase 1NCT07655518
A Positron Emission Tomography Study to Assess the Occupancy of M4 Muscarinic Acetylcholine Receptors by BMS-986521 in Healthy Adult Participants
A Phase 1, Open-label, Positron Emission Tomography (PET) Imaging Study to Evaluate M4 Muscarinic Acetylcholine Receptor Occupancy in the Central Nervous System Using [11C]MK-6884 PET Tracer Before and After Oral Administration of Multiple Doses of BMS-986521 in Healthy Adult Participants
Sponsor
Bristol-Myers Squibb
Enrollment
12 participants
Start Date
Jun 25, 2026
Study Type
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to Assess the Occupancy of M4 Muscarinic Acetylcholine Receptors by BMS-986521 in Healthy Adult Participants
Eligibility
Min Age: 18 YearsMax Age: 55 Years
Inclusion Criteria2
- Participants must be healthy male and female (as assigned at birth) who are individuals not of childbearing potential (INOCBP) without clinically significant deviation from normal in medical history, PE, 12-lead ECG, and clinical laboratory assessments.
- Participants must have a BMI of 18 to 30 kg/m\^2, inclusive, and total body weight ≥ 50 kg.
Exclusion Criteria3
- Participants must not have presence or history of any clinically relevant abnormality, condition, or disease-CNS, cardiovascular, renal, hepatic, hematologic, GI, endocrine, pulmonary, psychiatric, neurologic (eg, seizure disorder), or immunologic.
- Participants must not have history of rhabdomyolysis.
- Participants must not have current or recent (within 3 months of study intervention administration) clinically significant GI disease.
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Interventions
DRUGBMS-986521
Specified dose on specified days
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07655518
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