RecruitingPhase 2Phase 3NCT07655817

Oral Versus Intravenous Magnesium on Emergence Delirium

Effect of Oral Versus Intravenous Magnesium on Emergence Delirium in Children Undergoing Adenotonsillectomy: A Two-Center, Randomized, Double-Blind, Placebo-Controlled Study

Sponsor

Tanta University

Enrollment

360 participants

Start Date

Jul 1, 2026

Study Type

INTERVENTIONAL

Conditions

Emergence Delirium Children Magnesium adenotonsillectomy

Summary

This prospective randomized controlled study will be conducted to compare the effects of preoperative oral magnesium and intraoperative IV magnesium on the incidence and severity of emergence delirium in children undergoing adenotonsillectomy using sevoflurane anesthesia.

Eligibility

Min Age: 4 YearsMax Age: 7 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Magnesium glycinate, a drug called Magnesium sulfate injection, and others for people with children, emergence delirium, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 4 Years to 7 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMagnesium glycinate

cases will receive preoperative oral magnesium dose of 150 mg (10 ml of Magnesium Glycinate Liquid Trace syrup) at two hours before surgery, and will receive intraoperative IV (10 ml) of saline 0.9% over 10 minutes (1ml/min) after induction of anesthesia and before the start of surgical procedure.

DRUGMagnesium sulfate injection

cases will receive oral lemon juice (10 ml) at two hours before surgery, and will receive intraoperative IV magnesium sulfate dose of 30 mg/kg (diluted in saline to a total volume of 10 ml) over 10 minutes (1ml/min) after induction of anesthesia and before the start of surgical procedure.

OTHEROral juice and intravenous saline

cases will receive oral lemon juice (10 ml) at two hours before surgery and will receive intraoperative IV (10 ml) of saline 0.9% over 10 minutes (1ml/min) after induction of anesthesia and before the start of surgical procedure.