RecruitingNot ApplicableNCT07682389

Etiologic Diagnosis Algorithm in Infective Endocarditis

Development and Validation of An Algorithm of Etiological Diagnosis of Infective Endocarditis in Adults: An Open-Label Multicenter Randomized Clinical Trial

Sponsor

I.M. Sechenov First Moscow State Medical University

Enrollment

128 participants

Start Date

Jan 20, 2026

Study Type

INTERVENTIONAL

Conditions

Infective Endocarditis Microbiology

Summary

The goal of this study is to evaluate the impact of a diagnostic algorithm combining culture-based and molecular methods on the frequency of etiotropic antibiotic therapy prescription within 14 days of diagnosis of infective endocarditis

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Molecular tests (PCR, sequencing) and Standard Clinical Practice for people with infective endocarditis and microbiology. The study is currently recruiting participants at 3 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTMolecular tests (PCR, sequencing)

PCR and PCR with consequent sequencing of the blood (or tissue) will be performed in addition to the cultural methods in the experimental study arm

DIAGNOSTIC_TESTStandard Clinical Practice

Patients receive standard care with analysis of microorganisms in at least 2 or more separate blood culture sets and from cardiac tissue (if surgical treatment is performed); molecular test results are blinded for the treating physician