Pediatric Movement Disorders of Unknown Etiology in Vietnam (VPeMD)
Phenotypic and Genotypic Characterization of Pediatric Movement Disorders of Unknown Etiology in Vietnam
University of Medicine and Pharmacy at Ho Chi Minh City
50 participants
Apr 17, 2026
OBSERVATIONAL
Conditions
Summary
This observational patient registry aims to describe the clinical phenotypes and genetic findings of Vietnamese children with movement disorders of unknown etiology. Eligible participants are children with clinically confirmed movement disorders after evaluation by pediatric neurology specialists and after exclusion of clear acquired causes. The study will collect clinical data, neurological examination findings, available laboratory and imaging results, and video recordings of abnormal movements when consent is provided. Blood samples will be collected for whole-exome sequencing and related genetic analysis. Genetic variants will be classified according to accepted clinical genetics standards and compared with the patients' clinical phenotypes. The study is expected to improve understanding of the phenotypic and genotypic spectrum of pediatric movement disorders in Vietnam, support genetic counseling, and evaluate how genetic results may influence diagnosis, follow-up, prognosis, and treatment planning.
Eligibility
Inclusion Criteria5
- Children younger than 18 years old.
- Patients with clinically confirmed movement disorders based on direct examination and/or video review by at least two pediatric neurology specialists.
- Patients with movement disorders of unknown etiology after appropriate neurological evaluation and exclusion of clear acquired causes.
- Patients evaluated or treated at University Medical Center Ho Chi Minh City or Children's Hospital 1 during the study period.
- Patients and/or legal guardians who provide written informed consent for study participation and genetic testing.
Exclusion Criteria4
- Patients with isolated or transient primary tic disorders.
- Patients with a confirmed acquired cause of movement disorder.
- Patients or legal guardians who decline participation or withdraw from the study.
- Patients with insufficient clinical information or unavailable biological samples for genetic analysis.
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Interventions
Whole-exome sequencing will be performed on DNA extracted from peripheral blood samples to identify genetic variants associated with pediatric movement disorders. The test is used for genetic analysis and genotype-phenotype correlation in this observational registry and is not assigned as a treatment intervention.
Locations(2)
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NCT07695610