Two Intravenous Doses of Ketamine in Reducing the Oculocardiac Reflex in Adult Patients Undergoing Ophthalmic Surgery
Evaluation of Two Intravenous Doses of Ketamine in Reducing the Oculocardiac Reflex in Adult Patients Undergoing Ophthalmic Surgery: A Randomized Controlled Double-Blinded Trial
Cairo University
40 participants
Jul 1, 2026
INTERVENTIONAL
Conditions
Summary
This study aims to evaluate whether a lower dose of ketamine (0.5 mg/kg IV) may be as effective as a higher dose (0.75 mg/kg IV) in reducing oculocardiac reflex (OCR) incidence in adult patients undergoing ophthalmic surgery.
Eligibility
Inclusion Criteria4
- Age from 18 to 65 years old.
- Both sexes.
- American Society of Anesthesiologists (ASA) physical status I, II.
- Scheduled for elective ophthalmic surgery involving extraocular muscle traction under general anesthesia.
Exclusion Criteria5
- Ketamine contraindications (e.g., hypersensitivity, uncontrolled hypertension)
- History of cardiac arrhythmia or conduction disorder
- Glaucoma or raised intraocular pressure
- ASA status greater than II
- Patient refusal.
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Interventions
Patients will receive 0.5 mg/kg intravenous ketamine hydrochloride.
Patients will receive 0.75 mg/kg intravenous ketamine hydrochloride.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07708740