Ketamine Clinical Trials

9 recruiting

Ketamine Trials at a Glance

32 actively recruiting trials for ketamine are listed on ClinicalTrialsFinder across 6 cities in 7 countries. The largest study group is Not Applicable with 13 trials, with the heaviest enrollment activity in Beijing, Cairo, and Nanjing. Lead sponsors running ketamine studies include Peking University First Hospital, Beijing Tiantan Hospital, and Cairo University.

Browse ketamine trials by phase

Treatments under study

About Ketamine Clinical Trials

Looking for clinical trials for Ketamine? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Ketamine trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Ketamine clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 32 trials

Recruiting

Natural History of Depression, Bipolar Disorder and Suicide Risk

Molecular Mechanisms of Pharmacological ActionDepressive SymptomsSuicide+17 more
National Institute of Mental Health (NIMH)500 enrolled1 locationNCT06462196
Recruiting
Not Applicable

Effect of Intravenous Ketamine Combined With Spinal Anesthesia on Sensory Block Duration Compared to Spinal Anesthesia Alone in Lower Limb Surgeries in Geriatrics.

IV Ketamine With Spinal Block
Cairo University61 enrolled1 locationNCT07520487
Recruiting
Phase 3

Nebulized Ketamine for the Treatment of Major Depressive Disorder

MidazolamDepressive SymptomSevere Depression+14 more
Theresa Jacob, PhD, MPH40 enrolled1 locationNCT06752759
Recruiting
Phase 2

Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

DepressionDepressive DisorderMolecular Mechanisms of Pharmacological Action+10 more
National Institute of Mental Health (NIMH)50 enrolled1 locationNCT06511908
Recruiting

Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients

OxygenationAirway ManagementCritically Ill+3 more
Zeliha Alicikus4 enrolled1 locationNCT07222007
Recruiting
Phase 4

Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery

SurgeryEsketamineDexmedetomidine+1 more
Peking University First Hospital316 enrolled1 locationNCT07308756
Recruiting
Not Applicable

Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass

Coronary Artery Disease (CAD)FentanylLeft Ventricular (LV) Systolic Dysfunction+4 more
Cairo University40 enrolled1 locationNCT07248202
Recruiting
Not Applicable

Premedication in Children: a Clinical Trial Comparing Oral Ketamine and Oral Clonidine With Respect to Sedation Level and Opioid Consumption in Pediatrics Undergoing Elective Lower Abdominal Day-case Surgery.

Pediatric SedationClonidine SedationKetamine Sedation
Cairo University84 enrolled1 locationNCT07461376
Recruiting
Phase 2

Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults

Pain ManagementSickle Cell DiseaseVaso-Occlusive Crises+2 more
Mohsen Saidinejad120 enrolled1 locationNCT07369024
Recruiting
Not Applicable

The Efficacy and Safety of Short Term S-ketamine Infusion as an Adjunctive Therapy in Patients With Fibromyalgia

EsketamineFibromyalgiaPregabalin
Beijing Tiantan Hospital106 enrolled1 locationNCT07230171
Recruiting
Early Phase 1

Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study

DepressionEsketamineAdolescent+1 more
Min Su220 enrolled2 locationsNCT07247968
Recruiting
Not Applicable

Comparison of the Hemodynamic Effects of Ketamine - Dexmedetomidine (Ketodex) Versus Propofol-ketamine Admixture (Ketofol) During Induction of Anesthesia in Elderly: A Randomized Comparative Study

Ketamine-dexmedetomidine Induction of Anesthesia
Kasr El Aini Hospital102 enrolled1 locationNCT07002073
Recruiting
Phase 4

Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia

EsketamineDexmedetomidinePreoperative Anxiety+5 more
Second Affiliated Hospital of Wenzhou Medical University80 enrolled2 locationsNCT06853431
Recruiting
Phase 4

Sedation With Dexmedetomidine-esketamine Combination and Delirium in ICU Patients

Older PatientsEsketamineDexmedetomidine+3 more
Peking University First Hospital100 enrolled1 locationNCT07151716
Recruiting
Not Applicable

Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension

Brain IschemiaKetamineMagnesium Sulfate+6 more
University General Hospital of Patras150 enrolled1 locationNCT07181564
Recruiting
Phase 4

Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery

EsketamineDexmedetomidineScoliosis Correction
Peking University First Hospital312 enrolled1 locationNCT06062550
Recruiting
Phase 4

Effect of Dexmedetomidine and Esketamine on Catheter-related Bladder Discomfort

EsketamineDexmedetomidineUrinary Catheter+1 more
Peking University First Hospital1,740 enrolled2 locationsNCT06399185
Recruiting
Phase 4

Immunoinflammatory Regulation of Esketamine in Septic Patients

SepsisInflammatory ResponseEsketamine+1 more
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology100 enrolled2 locationsNCT04843982
Recruiting
Not Applicable

Application of Remimazolam, Dexmedetomidine, and Esketamine in Pediatric Preoperative Sedation

EsketamineDexmedetomidineRemimazolam
Maternal and Child Health Hospital of Hubei Province150 enrolled1 locationNCT07050212
Recruiting
Not Applicable

Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Open Rhinoplasty

KetamineIntraoperativeMagnesium Sulfate
Ain Shams University50 enrolled1 locationNCT06966518