RecruitingNCT07710287

Evaluation of the Accuracy of Immunostaining of Claudin 2 to Detect Active or Inactive Inflammation in Endoscopic Biopsies of IBD

Histologic Healing in IBD: Comparison of "Standard" Scores With Expression of Claudin 2 and Impact on Outcomes

Sponsor

IRCCS Policlinico S. Donato

Enrollment

100 participants

Start Date

Feb 14, 2025

Study Type

OBSERVATIONAL

Conditions

Crohn Disease Ulcerative Colitis (UC)

Summary

In view of the increasing evidence of the importance of mucosal healing as a combination of endoscopic and histologic healing, and the complexity and lack of complete agreement of the evaluation of histologic healing in IBD, the aim of this study will be to evaluate the accuracy of a new methodology, the immunostaining for Claudine 2 as compared to others standard well-accepted scoring for histologic activity in IBD. The aim is compare the accuracy of this methodology and in addition the correlation with outcomes (i.e. relapse, hospitalization, surgery).

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a new treatment for people with crohn disease and ulcerative colitis (uc). The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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