RecruitingNCT07720414

Effects of GLP-1 RAs on Human Lactation Outcomes


Sponsor

University of Colorado, Denver

Enrollment

18 participants

Start Date

Jul 1, 2026

Study Type

OBSERVATIONAL

Conditions

Summary

There is increasing interest in using GLP-1 Receptor Agonist (GLP-1 RA) medications after pregnancy. This study is designed to determine if these medications affect breastmilk production or the nutritional makeup of breastmilk. The main questions the study will address are: * Does GLP-1 RA-induced weight loss increase or decrease breastmilk production? * Does GLP-1 RA-induced weight loss affect the nutritional composition of milk, including milk fat content? Researchers will assess milk production rates before and after mothers begin taking injected GLP-1 RA medications to decrease their body weight. Weight loss will be confirmed with 7-day body weight averages. Participants will: * Weigh themselves and report measurements daily. * Participate in 2-3 morning study visits over approx. 2.5-4.5 months (approx. 3-3.5hrs each). During each visit, participants will: * Use a study provided breastpump to express milk 3 times hourly for measurement of hourly milk production. * Provide 1-3 oz of milk for further study. * Answer questions about breastfeeding patterns.


Eligibility

Sex: FEMALE

Inclusion Criteria7

  • Breastfeeding mothers of single or multiple infants.
  • Milk removal at least 4x daily
  • Eligible for a GLP-1 RA administered subcutaneously (oral GLP-1 RAs contain absorption enhancers, which may drive accumulation in milk)
  • Access to a breastpump, if needed for maintaining breastfeeding behaviors.
  • Willingness to provide 1-3 oz of breastmilk per study visit.
  • Willingness to track and report body weight daily.
  • Willingness to maintain breastfeeding behaviors for the duration of the study.

Exclusion Criteria2

  • Currently taking GLP-1 RA medication or other weight loss medication
  • Induced lactation, due to unknowns regarding the durability of the mammary gland's milk production after exogenous stimulation.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGInjected GLP-1 Receptor Agonists and Dual Agonists

Participants are prescribed this medication by their care provider(s) as part of their postnatal clinical care, including but not limited to semaglutide and tirzepatide. The investigators do not provide, manage, or assign the medication.


Locations(1)

University of Colorado Anschutz School of Medicine

Aurora, Colorado, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07720414


Related Trials