Weight Loss Clinical Trials

65 recruiting

Weight Loss Trials at a Glance

72 actively recruiting trials for weight loss are listed on ClinicalTrialsFinder across 6 cities in 25 countries. The largest study group is Not Applicable with 42 trials, with the heaviest enrollment activity in New York, Chicago, and Los Angeles. Lead sponsors running weight loss studies include Boston Scientific Corporation, Chinese Academy of Sciences, and University of Michigan.

Browse weight loss trials by phase

Treatments under study

About Weight Loss Clinical Trials

Looking for clinical trials for Weight Loss? There are currently 65 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Weight Loss trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Weight Loss clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 72 trials

Recruiting
Phase 2

Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment

ObesityWeight LossEating+1 more
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)148 enrolled1 locationNCT00739362
Recruiting
Not Applicable

Dyad Plus Effectiveness/Feasibility

Weight LossPediatric ObesityFamily and Household+2 more
Wake Forest University Health Sciences90 enrolled1 locationNCT04036331
Recruiting
Not Applicable

Adipocyte-Derived Extracellular Vesicles, Weight Loss, and Endothelial Function

ObesityWeight Loss
University of Colorado, Boulder84 enrolled1 locationNCT06776081
Recruiting
Not Applicable

Randomized Study on Transoral Outlet Reduction and Lifestyle Changes for Weight Regain After Gastric Bypass

Weight LossWeight Regain
Boston Scientific Corporation108 enrolled9 locationsNCT07015424
Recruiting

Endoscopic Bariatric Therapies (EBTs): A Retrospective and Prospective Multicenter Registry

ObesityWeight LossGastro Esophageal Reflux+1 more
Weill Medical College of Cornell University9,999 enrolled1 locationNCT04494048
Recruiting

Five PLus Year EffIcacy of Endoscopic Sleeve Gastroplasty (ESG) for Sustained WeigHT Loss

Weight LossObesity and Obesity-related Medical Conditions
Boston Scientific Corporation100 enrolled8 locationsNCT06894498
Recruiting
Not Applicable

Family COMIDA (Consumo de Opciones Más Ideales De Alimentos) (Eating More Ideal Food Options)

ObesityWeight LossChild Obesity
Memorial Sloan Kettering Cancer Center1,319 enrolled1 locationNCT07144800
Recruiting
Not Applicable

The Sleep2BWell Trial

Diet, HealthyWeight LossBlood Pressure+2 more
Columbia University150 enrolled2 locationsNCT06565104
Recruiting
Not Applicable

Metabolic Adaptations to Weight Loss With and Without Exercise

ObesityInsulin ResistanceWeight Loss+3 more
University of Michigan68 enrolled1 locationNCT05806801
Recruiting
Not Applicable

The Impact of Lifestyle Intervention on Weight and Fertility in Obese Males

ObesityWeight LossMale Fertility+2 more
Third Affiliated Hospital of Zhengzhou University98 enrolled1 locationNCT06339840
Recruiting
Phase 2

Fasted vs. Fed State Exercise

ExerciseObesityWeight Loss
Arkansas Colleges of Health Education40 enrolled1 locationNCT07487090
Recruiting
Not Applicable

Probiotic Intervention on Body Weight

ObesityWeight LossProbiotic Intervention+1 more
Chinese Academy of Sciences140 enrolled1 locationNCT06989177
Recruiting
Not Applicable

Protein Supplementation Intervention on Body Weight

ObesityWeight Loss
Chinese Academy of Sciences140 enrolled1 locationNCT06989203
Recruiting
Not Applicable

Effect of Dehydration on Sleep Quality, Cognitive Skills, and Electromyographic Responses in Combat Athletes

Weight LossSleepDehydration+1 more
Abant Izzet Baysal University12 enrolled1 locationNCT07118904
Recruiting
Phase 4

Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder

ObesityWeight LossBipolar I Disorder+3 more
Mayo Clinic100 enrolled1 locationNCT07213466
Recruiting
Not Applicable

Unintentional Weight Loss and Cancer: A Prospective Trial of Patient-centered Weight Tracking Combin

Unintended Weight Loss
Case Comprehensive Cancer Center1,000 enrolled1 locationNCT05481697
Recruiting
Not Applicable

Effect of a Postbiotic Supplementation in Overweight and Obese Subjects: A Randomized Controlled Trial (PARABIOTICS-2).

Weight LossNutrition, HealthyOverweight and Obesity
Clinica Universidad de Navarra, Universidad de Navarra114 enrolled1 locationNCT07165431
Recruiting
Phase 3

VK2735 for Weight Management Type 2 Diabetes Phase 3 (VANQUISH 2)

Weight Loss
Viking Therapeutics, Inc.1,100 enrolled134 locationsNCT07104383
Recruiting
Not Applicable

WISE-2B Brain Study (Weight Loss Intervention Surgical Effects on Brain Function)

Weight LossDiabetes
University of Florida120 enrolled1 locationNCT06861790
Recruiting
Phase 2

Aleniglipron Phase 2 in Type 2 Diabetes Mellitus

ObesityWeight LossObese+1 more
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics50 enrolled17 locationsNCT07400588