Weight Loss Clinical Trials

79 recruitingLast updated: June 17, 2026

There are 79 actively recruiting weight loss clinical trials across 25 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3. Top locations include New York, New York, United States, Chicago, Illinois, United States, Los Angeles, California, United States. Updated daily from ClinicalTrials.gov.


Weight Loss Trials at a Glance

79 actively recruiting trials for weight loss are listed on ClinicalTrialsFinder across 6 cities in 25 countries. The largest study group is Not Applicable with 45 trials, with the heaviest enrollment activity in New York, Chicago, and Los Angeles. Lead sponsors running weight loss studies include Boston Scientific Corporation, Chinese Academy of Sciences, and University of Michigan.

Browse weight loss trials by phase

Treatments under study

About Weight Loss Clinical Trials

Looking for clinical trials for Weight Loss? There are currently 73 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Weight Loss trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Weight Loss clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 79 trials

Recruiting
Phase 2

Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment

ObesityWeight LossEating+1 more
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)148 enrolled1 locationNCT00739362
Recruiting
Not Applicable

Randomized Study on Transoral Outlet Reduction and Lifestyle Changes for Weight Regain After Gastric Bypass

Weight LossWeight Regain
Boston Scientific Corporation108 enrolled9 locationsNCT07015424
Recruiting
Not Applicable

Unintentional Weight Loss and Cancer: A Prospective Trial of Patient-centered Weight Tracking Combined With GRAIL Galleri Testing to Improve Early Detection

Unintended Weight Loss
Case Comprehensive Cancer Center1,000 enrolled1 locationNCT05481697
Recruiting
Not Applicable

Orbera365 Intragastric Balloon System (Abbreviated as'Orbera365')

Weight Loss
Boston Scientific Corporation144 enrolled1 locationNCT07195708
Recruiting
Not Applicable

Exercise Effects on Adipose Tissue Structure and Function

ObesityInsulin ResistanceWeight Loss+3 more
University of Michigan46 enrolled1 locationNCT04812314
Recruiting
Phase 1

A Study to Evaluate the Pharmacokinetics of HRS9531 Injection in Participants With Mild, Moderate, and Normal Hepatic Function

Diabetes MellitusWeight Loss
Fujian Shengdi Pharmaceutical Co., Ltd.24 enrolled1 locationNCT07540754
Recruiting
Not Applicable

Metabolic Health, Bones and Nuts During Weight Loss in Adults

Obesity and OverweightWeight LossBone Density
Rutgers, The State University of New Jersey44 enrolled1 locationNCT06949280
Recruiting
Phase 1

Semaglutide (SEMA) for Alcohol Use Disorder (AUD) After Metabolic and Bariatric Surgery (MBS)

Weight LossAlcohol Use DisorderBariatric Surgery Patients
Yale University10 enrolled1 locationNCT07223983
Recruiting
Phase 2

Safely Optimizing Body Weight With TCMCB07 in Patients With Newly Diagnosed Colorectal Cancer Undergoing Chemotherapy

Cancer Weight Loss
Endevica Bio120 enrolled26 locationsNCT06937177
Recruiting

Five PLus Year EffIcacy of Endoscopic Sleeve Gastroplasty (ESG) for Sustained WeigHT Loss

Weight LossObesity and Obesity-related Medical Conditions
Boston Scientific Corporation100 enrolled8 locationsNCT06894498
Recruiting
Not Applicable

Testing a Tailored Approach to Long-Term Weight Loss Success

Weight LossObesity, OverweightWeight Regain
University of Utah30 enrolled1 locationNCT07577765
Recruiting
Not Applicable

Adipocyte-Derived Extracellular Vesicles, Weight Loss, and Endothelial Function

ObesityWeight Loss
University of Colorado, Boulder84 enrolled1 locationNCT06776081
Recruiting
Not Applicable

Dyad Plus Effectiveness/Feasibility

Weight LossPediatric ObesityFamily and Household+2 more
Wake Forest University Health Sciences90 enrolled1 locationNCT04036331
Recruiting

Changes in Taste and Eating Habits Associated With GLP-1 Agonists in Weight Loss Patients

Weight LossObesity, OverweightTaste Alterations+1 more
San Raffaele Telematic University150 enrolled4 locationsNCT07229170
Recruiting

Endoscopic Bariatric Therapies (EBTs): A Retrospective and Prospective Multicenter Registry

ObesityWeight LossGastro Esophageal Reflux+1 more
Weill Medical College of Cornell University9,999 enrolled1 locationNCT04494048
Recruiting
Not Applicable

Family COMIDA (Consumo de Opciones Más Ideales De Alimentos) (Eating More Ideal Food Options)

ObesityWeight LossChild Obesity
Memorial Sloan Kettering Cancer Center1,319 enrolled1 locationNCT07144800
Recruiting
Not Applicable

Metabolic Adaptations to Weight Loss With and Without Exercise

ObesityInsulin ResistanceWeight Loss+3 more
University of Michigan68 enrolled1 locationNCT05806801
Recruiting
Not Applicable

The Sleep2BWell Trial

Diet, HealthyWeight LossBlood Pressure+2 more
Columbia University150 enrolled2 locationsNCT06565104
Recruiting
Phase 2

Effects of Tirzepatide on Muscle and Vascular Health in Obese Older Adults

Weight LossObesity PreventionSarcopenia in Elderly+2 more
The University of Texas Health Science Center at San Antonio20 enrolled1 locationNCT06811324
Recruiting
Not Applicable

The Impact of Lifestyle Intervention on Weight and Fertility in Obese Males

ObesityWeight LossMale Fertility+2 more
Third Affiliated Hospital of Zhengzhou University98 enrolled1 locationNCT06339840