RecruitingNot ApplicableNCT07721766

Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training

HyperLa: Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training: A Multi-centre Study by the HyperLa Study Group

Sponsor

Technical University of Munich

Enrollment

120 participants

Start Date

May 4, 2026

Study Type

INTERVENTIONAL

Conditions

Muscle hypertrophy Healthy Volunteers Glycolysis Moderately Trainend

Summary

The HyperLa study investigates whether a person's "glycolyticness"-the efficiency with which their body uses glycolysis for energy-can predict how much their muscles will grow (hypertrophy) in response to resistance training. Participants will undergo a specialized "vLapeak" test, which measures the maximal rate of lactate accumulation during a 10-second all-out cycling sprint, to determine their individual glycolytic power. Following this initial assessment, participants will complete eight weeks of standardized, twice-weekly resistance training focused on the lower body. The study aims to determine if individuals with higher initial vLapeak values experience greater increases in muscle size compared to those with lower values. This research may help explain why people respond differently to exercise and support the development of personalized training programs.

Eligibility

Min Age: 18 YearsMax Age: 39 Years

Inclusion Criteria4

Body Mass Index (BMI) between 20-29 kg/m2
No structured resistance training performed in the last twelve months.
Maximum of four sessions per week of recreational or low-to-moderate aerobic endurance activity.
No history of competitive strength or physique sports.

Exclusion Criteria5

Diagnosed cardiovascular, pulmonary, metabolic, neuromuscular, or orthopaedic disease that contraindicates exercise.
Positive response to any question on the PAR-Q 2025 questionnaire.
Current use of anabolic steroids, creatine, or other substances known to strongly influence muscle hypertrophy.
Regular engagement in shift work.
Women who are pregnant or breastfeeding.

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Interventions

BEHAVIORALHypertrophy-focused Resistance Training

Standardized training consisting of twice-weekly supervised sessions for 8 weeks. Each session includes 4 sets of 8-12 repetitions of leg press (or Smith-machine squat) and leg extensions. Training intensity progresses from an RPE of 6 to voluntary muscular failure starting from week three.