Temporal Interference Stimulation of Hypothalamus in Patients With Narcolepsy Type 1
Efficacy and Safety of Temporal Interference Stimulation of Hypothalamus in Patients With Narcolepsy Type 1: A Randomised, Double-blind, Sham-Controlled, Single-Centre Trial
Xijing Hospital
24 participants
Aug 1, 2026
INTERVENTIONAL
Conditions
Summary
Narcolepsy type 1 (NT1) is a chronic brain disorder caused by selective loss or dysfunction of orexin (hypocretin) neurons in the lateral hypothalamus, for which current pharmacological treatments offer limited efficacy. Temporal interference (TI) stimulation is a recently developed noninvasive neuromodulation technique that enables focal modulation of deep brain structures. In this randomized, double-blind study, we developed a theta-burst patterned TI protocol and evaluated its effects in patients with NT1.
Eligibility
Plain Language Summary
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Interventions
For the active TI stimulation, the current was applied for 40 minutes per session.
For the sham stimulation, a brief 30-second current was delivered at the beginning and at the end of each session, with no current applied in between.
Locations(1)
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NCT07727239