RecruitingNot ApplicableNCT07793006

New Approaches for the Diagnosis of Lymphoma and Multicentric Castleman Disease

Sponsor

Indiana University

Enrollment

500 participants

Start Date

Mar 17, 2025

Study Type

INTERVENTIONAL

Conditions

Hodgkin Lymphoma Non-Hodgkin Lymphoma Lymphadenopathy HIV Kaposi Sarcoma Herpesvirus -Associated Multicentric Castleman Disease Tiny Isothermal Nucleic Acid Amplification System

Summary

Persons living with HIV (PLWH) in sub-Saharan Africa (SSA), lymphadenopathy often portends one of a number of life-threatening diseases including tuberculosis, lymphoma, and multicentric Castleman disease (MCD). Overcoming these delays and missed diagnoses requires new approaches to identify lymphoma and MCD.

Eligibility

Min Age: 1 Year

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a procedure called Fine Needle Aspiration, a procedure called Lymph Node or Core Needle Biopsy, and others for people with hiv, hodgkin lymphoma, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 1 Year and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURELymph Node or Core Needle Biopsy

DNA isolation to be tested by nucleic acid amplification using the TINY device

PROCEDUREFine Needle Aspiration

The sample will be eluted into two tubes, one for Gene Xpert testing and one for storage for EBV and KSHV testing by qPCR and TINY.

DIAGNOSTIC_TESTTiny Isothermal Nucleic acid Amplification System (TINY)

Tiny Isothermal Nucleic acid Amplification System (TINY)

Locations(1)

Lighthouse Trust HIV Centers of Excellence

Lilongwe, Malawi

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NCT07793006

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