Intra-Abdominal Pressure Changes During Continuous Renal Replacement Therapy in Critically Ill Patients
Prospective Evaluation of Intra-Abdominal Pressure Changes in Critically Ill Patients Receiving Continuous Renal Replacement Therapy
Bursa Yuksek Ihtisas Training and Research Hospital
95 participants
Jul 20, 2026
OBSERVATIONAL
Conditions
Summary
This prospective observational study will evaluate changes in intra-abdominal pressure in critically ill adult patients receiving continuous renal replacement therapy in the intensive care unit. Intra-abdominal pressure will be measured through the urinary bladder at predefined time points during therapy. The study will also assess the relationship between intra-abdominal pressure changes and clinical variables, including fluid balance, hemodynamic parameters, vasopressor requirement, urine output, severity scores, duration of renal replacement therapy, intensive care unit and hospital length of stay, and 30-day survival. No additional treatment or therapeutic intervention will be administered for research purposes.
Eligibility
Inclusion Criteria4
- Age 18 years or older
- Admission to the intensive care unit
- Receiving continuous renal replacement therapy (CRRT)
- Presence of an indwelling urinary (Foley) catheter for intra-abdominal pressure measurement
Exclusion Criteria7
- Pregnancy
- Open abdominal wound or open abdomen
- Neurogenic bladder
- History of bladder surgery
- Pelvic hematoma
- Pelvic fracture
- Presence of an intra-abdominal mass or other anatomical/technical condition that may compromise the reliability of intravesical pressure measurement
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Interventions
Intravesical intra-abdominal pressure will be measured via the existing urinary catheter at baseline and at 6, 12, 24, 48, and 72 hours after initiation of continuous renal replacement therapy (CRRT). Measurements will be performed for study data collection only. No therapeutic intervention or modification of routine clinical management will be undertaken based solely on the study measurements.
Locations(1)
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NCT07823387