Phase 1 Action Clinical Trials
33 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 33 trials
Recruiting
Phase 1Phase 2
Opioid Drug Interaction Study
Drug Kineticsdrug interactions
Shanna Babalonis, PhD25 enrolled1 locationNCT06757140
Recruiting
Phase 1Phase 2
Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease
Quality of LifeDepression, AnxietyStress Reaction+1 more
Children's Hospital Los Angeles66 enrolled1 locationNCT05685368
Recruiting
Phase 1
A Study to Learn About the Effect of Study Medicine Called PF-08653944 on How Quickly the Stomach Empties Its Content in Healthy Adults With Overweight or Obesity
ObesityOverweightDrug Interaction+1 more
Pfizer20 enrolled1 locationNCT07508241
Recruiting
Phase 1
Novel Approaches for Improving Vascular Function in Veterans With HFpEF
InflammationHeart Failure With Preserved Ejection Fraction
VA Office of Research and Development90 enrolled1 locationNCT06312748
Recruiting
Phase 1
Drug-Drug Interaction Study of ABP-671 in Gout Patients
GoutGout ChronicDDI (Drug-Drug Interaction)
Atom Therapeutics Co., Ltd20 enrolled1 locationNCT07367971
Recruiting
Phase 1
A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction
Heart Failure With Reduced Ejection Fraction
Novartis Pharmaceuticals12 enrolled3 locationsNCT07465653
Recruiting
Phase 1
A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Heart Failure With Preserved Ejection Fraction (HFpEF)Heart
Vasa Therapeutics42 enrolled21 locationsNCT07219511
Recruiting
Phase 1Phase 2
Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease
Heart FailureChronic Kidney DiseasesKidney Diseases+1 more
Northwestern University60 enrolled1 locationNCT05719714
Recruiting
Phase 1
Safety and Efficacy of LOw DOse COlchicine in Patients With STatin INTolerance: the LODOCO STINT Pilot Study
Statin Adverse Reaction
Virginia Commonwealth University30 enrolled1 locationNCT06874192
Recruiting
Phase 1Phase 2
Evaluation of Stem Cell Exosomes Versus Platelet-Rich Fibrin in Tooth Extraction Socket Healing
Tooth ExtractionAlveolar Bone LossBone Regeneration
Al Salam University40 enrolled1 locationNCT07508033
Recruiting
Phase 1
The Effect of Losartan on Cephalexin
HealthyPossible Interaction Between Losartan and Cephalexin
Aleksi Tornio12 enrolled1 locationNCT07300670
Recruiting
Phase 1Phase 2
Safety and Performance, and Dose, of OsteoAdapt DE in Localized Alveolar Ridge Augmentations
Tooth Extraction Site HealingRidge AugmentationBone Graft
Theradaptive, Inc45 enrolled6 locationsNCT07078331
Recruiting
Phase 1Phase 2
Hypofractionated Radiotherapy Plus Immunochemotherapy for Neoadjuvant Treatment of Gastroesophageal Junction Adenocarcinoma
Gastroesophageal Junction AdenocarcinomaHypofractionated Radiotherapy
West China Hospital84 enrolled4 locationsNCT07182565
Recruiting
Phase 1
A Real-World Study of Fecal Transplants for Cancer Therapy Side Effects
Antineoplastic AgentsGastrointestinal NeoplasmsFecal Microbiota Transplantation (FMT)+1 more
Second Affiliated Hospital, School of Medicine, Zhejiang University90 enrolled1 locationNCT07319364
Recruiting
Phase 1
Safety and PK of Ceftibuten-ledaborbactam Etzadroxil Fixed-dose Combination
Healthy VolunteerSafetyPharmacokinetics+2 more
Basilea Pharmaceutica46 enrolled1 locationNCT06733675
Recruiting
Phase 1
to Evaluate the Safety and the Pharmacokinetic and Pharmacodynamic Interactions Between JP-1366 and Clopidogrel, Aspirin, Atorvastatin and Apixaban
Drug-Drug Interaction (DDI)
Onconic Therapeutics Inc.96 enrolled1 locationNCT07265466
Recruiting
Phase 1Phase 2
Hypofractionated Radiotherapy Combined With Immunochemotherapy for Conversion Treatment of Gastroesophageal Junction Adenocarcinoma
ChemotherapyGastroesophageal Junction AdenocarcinomaImmunotherapy+1 more
West China Hospital88 enrolled4 locationsNCT07072351
Not Yet Recruiting
Phase 1
Guanethidine for Pulmonary Hypertension with Heart Failure with a Preserved Ejection Fraction (PH-HFpEF)
Heart Failure with a Preserved Ejection Fraction
Alfred Health15 enrolled1 locationACTRN12625000817448
Recruiting
Phase 1
Safety of SBRT With Anti-PD1 and Anti-IL-8 for the Treatment of Multiple Metastases in Advanced Solid Tumors and Melanoma
MelanomaNeoplasmsNeoplasms by Site+7 more
Yana Najjar50 enrolled2 locationsNCT04572451
Recruiting
Phase 1
Pharmacogenomic Contributions to Trihexyphenidyl Biotransformation and Response in Children With Dystonic Cerebral Palsy
Genetic PredispositionDystoniaPediatric Disorder+5 more
Children's Mercy Hospital Kansas City40 enrolled1 locationNCT06554288