Novel Approaches for Improving Vascular Function in Veterans With HFpEF

This study is looking at new treatments to improve blood vessel function in veterans who have a type of heart failure where the heart pumps normally but the heart muscle is too stiff (called HFpEF). Researchers are testing whether a statin medication can help blood vessels work better in these patients. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with heart failure with preserved ejection fraction (HFpEF — heart pumps normally but the heart is stiff) - Your heart function score is mild to moderate (NYHA class I, II, or III) - Your blood markers for heart failure (BNP or NT-proBNP) are elevated, or you were hospitalized for heart failure in the past year **You may NOT be eligible if...** - You have an allergy to statins (cholesterol-lowering drugs) - Your heart function has previously been less than 50% pumping capacity - You have severe heart failure (NYHA class IV) - You have significant untreated valve disease, active liver disease, or unexplained elevated liver enzymes - You are a woman of childbearing age who is not using contraception Talk to your doctor to see if this trial is right for you.