Acute Respiratory Distress Clinical Trials

133 recruitingLast updated: June 18, 2026

There are 133 actively recruiting acute respiratory distress clinical trials across 37 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4, Early Phase 1. Top locations include Houston, Texas, United States, New York, New York, United States, Beijing, Beijing Municipality, China. Updated daily from ClinicalTrials.gov.


Acute Respiratory Distress Trials at a Glance

133 actively recruiting trials for acute respiratory distress are listed on ClinicalTrialsFinder across 6 cities in 37 countries. The largest study group is Not Applicable with 50 trials, with the heaviest enrollment activity in Houston, New York, and Beijing. Lead sponsors running acute respiratory distress studies include Assistance Publique - Hôpitaux de Paris, Southeast University, China, and PPD Development, LP.

Browse acute respiratory distress trials by phase

Treatments under study

About Acute Respiratory Distress Clinical Trials

Looking for clinical trials for Acute Respiratory Distress? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Acute Respiratory Distress trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Acute Respiratory Distress clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 133 trials

Recruiting
Phase 2

Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)

InfectionsAcute Respiratory Distress Syndrome
BioAegis Therapeutics Inc.600 enrolled70 locationsNCT05947955
Recruiting

Lung Injury is One of the Primary Causes of Morbidity and Mortality in Critically Ill Patients. These Patients Will be Monitored for: 1) Immune Cell Activation 2) Blood-based Biomarkers. In Vitro Models Derived From These Samples Will be Treated With Novel Agent PIP-2 to Evaluate Its Efficacy.

ARDS (Acute Respiratory Distress Syndrome)
University of Pennsylvania36 enrolled1 locationNCT07125079
Recruiting
Early Phase 1

A Single Dose, Dose Escalation Clinical Trial on the Safety, Tolerability and Efficacy of Lyophilized Powder for Inhalation of Recombinant Human Keratinocyte Growth Factor-2 (Rh-KGF-2) in The Treatment of Patients With Acute Respiratory Distress Syndrome

ARDS (Moderate or Severe)ARDS (Acute Respiratory Distress Syndrome)
Shanghai Zhongshan Hospital24 enrolled1 locationNCT07558538
Recruiting
Phase 2Phase 3

Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome

Mechanical Ventilation ComplicationAcute Respiratory Distress SyndromeSedation Complication
Guy's and St Thomas' NHS Foundation Trust20 enrolled1 locationNCT06014138
Recruiting
Not Applicable

Titration of Positive End-expiratory Pressure: Comparison Between Manual Thoracic or Abdominal Compression and Electrical Impedance Tomography

ARDS (Acute Respiratory Distress Syndrome)
Centre Hospitalier Saint Joseph Saint Luc de Lyon30 enrolled2 locationsNCT07623590
Recruiting

Pulmonary Overdistension Assessment With Electrical Impedance Tomography in Patients With Acute Respiratory Distress Syndrom in Prone Position.

Acute Respiratory Distress Syndrome (ARDS)
Centre Hospitalier de la côte Basque30 enrolled1 locationNCT07090460
Recruiting
Phase 2

Corticosteroids in Hyperinflammatory Phenotype of Critical Illness

SepsisAcute Respiratory Distress Syndrome
Bin Du150 enrolled1 locationNCT07511582
Recruiting
Phase 1

Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HT31-1 for Treating ARDS

ARDS (Acute Respiratory Distress Syndrome)
HTIC, Inc24 enrolled2 locationsNCT07449572
Recruiting
Not Applicable

Effect of EIT-guided PEEP in ARDS Patients

ARDS (Acute Respiratory Distress Syndrome)
Southeast University, China2,400 enrolled3 locationsNCT06990477
Recruiting
Not Applicable

Effect of Continuous Prolonged Prone Position Versus Intermittent Daily Prone Position in ARDS

Acute Respiratory Distress Syndrome
Pontificia Universidad Catolica de Chile780 enrolled38 locationsNCT06854627
Recruiting

Study of the Immunological Pathophysiological Mechanisms Associated With Acute Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome (ARDS)
Assistance Publique - Hôpitaux de Paris50 enrolled1 locationNCT07395076
Recruiting
Phase 3

Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

Respiratory FailureAcute Respiratory Distress Syndrome
Beth Israel Deaconess Medical Center1,100 enrolled33 locationsNCT06066502
Recruiting
Phase 3

RECOMMEND Platform Trial

Intensive Care MedicineCritical IllnessCardiac Arrest (CA)+2 more
Australian and New Zealand Intensive Care Research Centre600 enrolled3 locationsNCT06526533
Recruiting
Phase 2

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)

Acute Respiratory Distress Syndrome (ARDS)ARDSAcute Respiratory Distress Syndrome+1 more
PPD Development, LP600 enrolled40 locationsNCT06703073
Recruiting
Phase 2

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort C: Bevacizumab

Acute Respiratory Distress Syndrome (ARDS)ARDSAcute Respiratory Distress Syndrome+1 more
PPD Development, LP200 enrolled40 locationsNCT06701656
Recruiting
Phase 2

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart

Acute Respiratory Distress Syndrome (ARDS)ARDSAcute Respiratory Distress Syndrome+1 more
PPD Development, LP200 enrolled40 locationsNCT06701669
Recruiting
Phase 2

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab

Acute Respiratory Distress Syndrome (ARDS)ARDSAcute Respiratory Distress Syndrome+1 more
PPD Development, LP200 enrolled40 locationsNCT06701682
Recruiting
Phase 3

Pirfenidone to Prevent Fibrosis in Ards.

Acute Respiratory Distress Syndrome (ARDS)
Università Vita-Salute San Raffaele130 enrolled17 locationsNCT05075161
Recruiting

The Feasibility of Pulmonary Perfusion Assessment Using Sodium Bicarbonate Contrast With Electrical Impedance Tomography: A Prospective Pilot Study

Acute Respiratory Distress Syndrome (ARDS)Acute Respiratory FailurePneumonia+2 more
First Affiliated Hospital of Wannan Medical College41 enrolled1 locationNCT07542366
Recruiting

Prediction of Inspiratory Effort Response to High PEEP in Patients Recovering From ARDS

Acute Respiratory Distress Syndrome
Sanatorio Anchorena San Martin30 enrolled1 locationNCT04524091