Early Phase 1 Acute Clinical Trials
42 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 42 trials
Recruiting
Early Phase 1
A Pilot Trial of Disposable Nitrous Oxide Canisters in Providing Pain Control During Burn Dressing Changes
Pain, AcuteBurns
University of Manitoba30 enrolled1 locationNCT03695887
Recruiting
Early Phase 1
The Role of NaV1.8 in Human Pain Models
PainHealthy Volunteer StudyAcute Pain
Medical University of Vienna66 enrolled1 locationNCT07511400
Recruiting
Early Phase 1
Allogeneic CMV-Specific CD19-CAR T Cells Plus CMV-MVA Triplex Vaccine After Matched Related Donor Hematopoietic Cell Transplant for the Treatment of Patients With High-Risk Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia
City of Hope Medical Center15 enrolled1 locationNCT06735690
Recruiting
Early Phase 1
A Clinical Study Evaluating the Safety and Efficacy of GT801 Injection in Adult Patients With Relapsed/Refractory CD19-positive B-cell Hematologic Malignancies and Autoimmune Hemolytic Anemia
Chronic Lymphocytic Leukemia (CLL)B-cell Acute Lymphoblastic Leukemia (B-ALL)B-cell Non-Hodgkin's Lymphoma (B-NHL)
Grit Biotechnology28 enrolled2 locationsNCT07205315
Recruiting
Early Phase 1
Multi-modality Imaging and Collection of Biospecimen Samples in Understanding Bone Marrow Changes in Patients With Acute Myeloid Leukemia Undergoing TBI and Chemotherapy
Acute Lymphoblastic LeukemiaAcute Myeloid Leukemia
City of Hope Medical Center74 enrolled1 locationNCT03422731
Recruiting
Early Phase 1
A Clinical Study Exploring the Safety, Efficacy and Cell Metabolic Kinetics of Universal Car-t Cell Injection in CD19 and / or CD20 Positive Relapsed / Refractory B-cell Acute Lymphoblastic Leukemia in Adolescents, Children and Adults
ALL (Acute B-Lymphoblastic Leukemia)
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology18 enrolled1 locationNCT07470073
Recruiting
Early Phase 1
Simvastatin Treatment to Improve Patient-reported Outcomes in Patients With Chronic Pancreatitis
Chronic PancreatitisRecurrent Acute Pancreatitis
Cedars-Sinai Medical Center90 enrolled5 locationsNCT05771675
Recruiting
Early Phase 1
Placebo-controlled Study of Single and Multiple Ascending Doses of UDP-003 in Healthy Human Participants and Patients
Atherosclerotic Cardiovascular DiseaseAcute Coronary Syndromes
Cyclarity Therapeutics, Inc.84 enrolled1 locationNCT06813339
Recruiting
Early Phase 1
CART123 T Cells in Relapsed or Refractory CD123+ Hematologic Malignancies: A Dose Escalation Phase I Trial
Myelodysplastic Syndromes (MDS)Precursor Cell Lymphoblastic Leukemia-LymphomaBlastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)+1 more
Institute of Hematology and Blood Transfusion, Czech Republic18 enrolled1 locationNCT06765876
Recruiting
Early Phase 1
JY231 (JY231) Injection for the Treatment of B-cell Acute Lymphoblastic Leukemia (B-ALL)
B-cell Acute Lymphoblastic Leukemia (B-ALL)
920th Hospital of Joint Logistics Support Force of People's Liberation Army of China20 enrolled1 locationNCT06514768
Recruiting
Early Phase 1
Clinical Study of LV009 Injection for the Treatment of Relapsed/Refractory CD19-Positive Hematologic and Lymphoid Malignancies
Acute Lymphoblastic Leukemia (ALL), AdultNon-Hodgkin Lymphoma (NHL)
PersonGen BioTherapeutics (Suzhou) Co., Ltd.19 enrolled1 locationNCT07312630
Recruiting
Early Phase 1
Positron Emission Tomography (PET) Imaging of Neuroinflammation in Patients With Neurological Dysfunction After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV 2) Infection
SARS CoV-2 Post-Acute Sequelae
University of Alabama at Birmingham60 enrolled1 locationNCT05656105
Recruiting
Early Phase 1
UPDATE AML: UPdated Disease Monitoring And Treatment for Enhanced Outcomes for Pediatric AML
Acute Myeloid LeukemiaPediatric AML
Joanna Yi36 enrolled1 locationNCT07059975
Recruiting
Early Phase 1
Study of Liraglutide (A Weight Loss Drug) in High Risk Obese Participants With Cognitive and Memory Issues
ObesityMultiple SclerosisLong COVID+4 more
University of Chicago30 enrolled1 locationNCT06171152
Recruiting
Early Phase 1
Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies
Multiple MyelomaLymphomaHematologic Malignancy+5 more
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins8 enrolled1 locationNCT06398457
Recruiting
Early Phase 1
Donor Derived CD117 CAR-T Cells in the Treatment of R/R Acute Myeloid Leukemia
Acute Myeloid Leukemia
Zhejiang University50 enrolled1 locationNCT07144020
Recruiting
Early Phase 1
The Efficacy and Safety Assessment of Allogeneic γδ T Cells in Patients With MRD-positive AML After Allo-HSCT
AMLAML (Acute Myelogenous Leukemia)
Institute of Hematology & Blood Diseases Hospital, China10 enrolled1 locationNCT07126782
Recruiting
Early Phase 1
XP-005 Personalized Vaccine Alone or in Combination With Toripalimab for the Prevention of Relapse After Remission in Acute Myeloid Leukemia
Acute Myeloid Leukemia
Shanghai Jiao Tong University School of Medicine60 enrolled1 locationNCT06980155
Recruiting
Early Phase 1
Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant
Acute Myeloid LeukemiaMyelodysplastic SyndromesChronic Myelomonocytic Leukemia+4 more
Omar Aljitawi24 enrolled1 locationNCT03964506
Recruiting
Early Phase 1
Off-the-shelf CD123 CAR-NK for R/R AML
Acute Myeloid Leukemia, in Relapse
Peking University People's Hospital12 enrolled1 locationNCT06201247