Phase 3 Adjuvant Clinical Trials
35 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–20 of 35 trials
Recruiting
Phase 3
Postoperative Radiotherapy Combined With Nimotuzumab Followed by Benmelstobart in High-Risk Patients With Head and Neck Squamous Cell Carcinoma
Head & Neck CancerPostoperative Adjuvant TreatmentHead & Neck Squamous Cell Carcinoma
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University370 enrolled1 locationNCT07445048
Recruiting
Phase 3
A Study to Assess the Efficacy and Safety of Zipalertinib Versus Placebo for Adjuvant Treatment in Participants With Stage IB-IIIA NSCLC With Uncommon EGFR Mutations, Following Complete Tumor Resection
Lung CancerEGFRNSCLC, Stage IB-IIIA+5 more
Taiho Oncology, Inc.360 enrolled253 locationsNCT07128199
Recruiting
Phase 3
Neoadjuvant of Axitinib Plus PD-1 to Improve Disease Free Survival of Patients With Renal Cell Carcinoma
Renal Cell CarcinomaNeoadjuvant
ZHOU FANGJIAN298 enrolled8 locationsNCT05738694
Recruiting
Phase 3
Flap Sparing in Postoperative Radiotherapy of Oral Cavity Cancers
Radiotherapy, AdjuvantOral Cavity CarcinomaFlap+1 more
Centre Francois Baclesse348 enrolled25 locationsNCT06798922
Recruiting
Phase 3
Adjuvant TACE in HCC With High-risk Recurrence Factors
Hepatocellular CarcinomaAdjuvantTransarterial Chemoembolization
Guangxi Medical University442 enrolled1 locationNCT07417397
Recruiting
Phase 3
No Axillary Surgical Treatment in Clinically Lymph Node Negative Patients on Ultrasonography After Neoadjuvant Chemotherapy
Breast CancerNeoadjuvant TherapySentinel Lymph Node Biopsy
Seoul National University Hospital464 enrolled1 locationNCT06704945
Recruiting
Phase 3
Adjuvant Oxaliplatin Plus S-1 Versus Docetaxel Plus S-1 for Stage III Gastric Cancer
Gastric Cancer (GC)Adjuvant ChemotherapyOxaliplatin+2 more
Ruijin Hospital387 enrolled5 locationsNCT07366528
Recruiting
Phase 3
CDK4/6 Inhibitors Combined With Standard Adjuvant Endocrine Therapy in High-Risk, HR+/HER2+ Early Breast Cancer Patients(CHESS)
Breast CancerAdjuvant Therapy
Fudan University1,903 enrolled1 locationNCT07019363
Recruiting
Phase 3
Megestrol Acetate in Improving Neoadjuvant Chemotherapy-Related Weight Loss in Locally Advanced CRC
Weight LossNeoadjuvant Chemotherapy
Sixth Affiliated Hospital, Sun Yat-sen University60 enrolled1 locationNCT06998758
Recruiting
Phase 3
Adjuvant Radiotherapy of Sintilimab Versus TACE for HCC
Radiotherapy, AdjuvantHepatocellular Carcinoma (HCC)Immune Checkpoint Inhibitor+2 more
Cancer Institute and Hospital, Chinese Academy of Medical Sciences286 enrolled1 locationNCT07186621
Recruiting
Phase 2Phase 3
Safety and Efficacy Study of Sorbitol With Neoadjuvant Chemotherapy Combined With Tirellizumab (PD-1 Inhibitor) in Patients With Locally Advanced Gastric Cancer
Gastric CancerImmunotherapyNeoadjuvant Therapies+1 more
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology80 enrolled1 locationNCT06826079
Recruiting
Phase 2Phase 3
Node-Sparing Short-Course Radiotherapy Sequential Chemotherapy and PD-1 Inhibitor for Mid/Low pMMR/MSS Rectal Cancer (MODIFI-RC-II)
Rectal CancerRadiotherapyNeoadjuvant Therapies+1 more
Sixth Affiliated Hospital, Sun Yat-sen University430 enrolled1 locationNCT06958432
Recruiting
Phase 3
Neoadjuvant Immunotherapy Plus Chemotherapy Followed by Concurrent Chemoradiotherapy and Consolidative Immunotherapy for Locally Advanced Non-small Cell Lung Cancer
Neoadjuvant TherapyImmunotherapyLocally Advanced Non-Small Cell Lung Cancer+1 more
Sun Yat-sen University497 enrolled1 locationNCT06734702
Recruiting
Phase 3
Neoadjuvant Cadonilimab Combined With Perioperative Oxaliplatin Plus S1 for Diffuse or Mixed Type of Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma
Neoadjuvant TherapyAdjuvant ChemotherapyGastric Cancer (Including Stomach and Gastroesophageal Junction [GEJ])+3 more
Zuoyi Jiao668 enrolled4 locationsNCT06949033
Recruiting
Phase 3
A Study to Assess the Efficacy and Safety of Firmonertinib Versus Placebo for Adjuvant Treatment in Participants With Stage IB - IIIB NSCLC With Uncommon Epidermal Growth Factor Receptor (EGFR) Mutations, Following Complete Surgical Resection With or Without Adjuvant Chemotherapy（FIRMOST）
NSCLCAdjuvant Treatment
Allist Pharmaceuticals, Inc.338 enrolled2 locationsNCT07010419
Recruiting
Phase 3
Personalized Long-course Radiotherapy Plus Chemotherapy With or Without Immunotherapy for LARC: PALACE Study
RadiotherapyImmunotherapyLocally Advanced Rectal Cancer (LARC)+2 more
West China Hospital184 enrolled1 locationNCT07020247
Recruiting
Phase 3
Neoadjuvant SNF Precision Therapy Phase III
Neoadjuvant Therapy
Fudan University404 enrolled1 locationNCT06913777
Recruiting
Phase 3
A Phase III, Active-Controlled Study of SHR-A1811 Versus Trastuzumab Emtansine (T-DM1) in HER2-Positive Primary Breast Cancer Participants With Residual Invasive Disease Following Neoadjuvant Therapy
HER2-Positive Primary Breast Cancer Participants With Residual Invasive Disease Following Neoadjuvant Therapy
Jiangsu HengRui Medicine Co., Ltd.1,600 enrolled2 locationsNCT06126640
Recruiting
Phase 3
Neoadjuvant Apatinib Combined With Sintilimab and Perioperative SOX Versus Neoadjuvant Sintilimab Combined With Perioperative SOX for Intestinal Type of Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma
Neoadjuvant TherapyAdjuvant ChemotherapyGastric Cancer (Including Stomach and Gastroesophageal Junction [GEJ])+3 more
Zuoyi Jiao682 enrolled4 locationsNCT06925243
Recruiting
Phase 2Phase 3
Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer.
Radiotherapy Side EffectNeoadjuvant TherapyChemotherapy+8 more
National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos400 enrolled1 locationNCT06758830