Flap Sparing in Postoperative Radiotherapy of Oral Cavity Cancers

This study tests whether the skin flap used to reconstruct the mouth after oral cavity cancer surgery can be "spared" (excluded) from the radiation field during post-surgical radiotherapy. Sparing the flap from radiation could reduce complications like tissue death or poor healing while still treating the cancer effectively. **You may be eligible if...** - You are 18 or older - You have oral cavity cancer (or oropharynx cancer with a flap extending into the oral cavity) - You had reconstructive surgery with a skin flap and surgical margins greater than 1 mm - You are scheduled to receive post-operative radiation therapy (IMRT or proton therapy) - You may also receive concurrent chemotherapy **You may NOT be eligible if...** - You had a small local flap reconstruction that limits radiation planning flexibility - You have had previous radiation treatment to the head and neck area Talk to your doctor to see if this trial is right for you.