Phase 1 Advanced Solid Cancer Clinical Trials
14 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–14 of 14 trials
Recruiting
Phase 1
ADCX-020 for the Treatment of Patients With Locally Advanced or Metastatic Cancers
Metastatic Solid TumorsAdvanced Solid CancersAdvanced Malignancy
Adcytherix SAS290 enrolled9 locationsNCT07238075
Recruiting
Phase 1
A Study in People With Advanced Cancer to Test How Well Different Doses of BI 3819026 Are Tolerated When Taken Alone and Together With Ezabenlimab
Advanced Solid CancerMetastatic Solid Cancer
Boehringer Ingelheim60 enrolled9 locationsNCT07607678
Recruiting
Phase 1Phase 2
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of INV-6452 in Adult Patients With Hormone Receptor Positive, Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Advanced/Metastatic Breast Cancer or Locally Advanced/Metastatic Solid Tumor
Ovarian CancerEndometrial CancerBreast Cancer (Locally Advanced or Metastatic)+2 more
Shenzhen Ionova Life Sciences Co., Ltd.201 enrolled1 locationNCT07612891
Recruiting
Phase 1
SIM0613 in Participants With Advanced Solid Tumors
Advanced Solid Cancer
Jiangsu Simcere Pharmaceutical Co., Ltd.294 enrolled1 locationNCT07618260
Recruiting
Phase 1Phase 2
A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially Beneficial for People With Advanced Solid Tumors Known to Express the Tumor Marker CA19-9
Advanced Solid Cancers
BioNTech SE245 enrolled10 locationsNCT07186842
Recruiting
Phase 1Phase 2
A Study to Evaluate ARV-806 in Adults With Advanced Cancer That Has the KRAS G12D Mutation
Advanced Solid CancerKRAS G12D Mutation
Arvinas Inc.159 enrolled14 locationsNCT07023731
Recruiting
Phase 1
A Phase I Study of SIM0609 in Adult Participants With Locally Advanced/Metastatic Solid Tumors
Advanced Solid Cancer
Jiangsu Simcere Pharmaceutical Co., Ltd.232 enrolled6 locationsNCT07265921
Recruiting
Phase 1
A Phase 1 Study of APX-343A as Monotherapy or in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors
Advanced Solid CancerAdvanced Solid Tumor (Phase 1)
Aptabio Therapeutics, Inc.110 enrolled3 locationsNCT07123415
Recruiting
Phase 1Phase 2
A Study of MHB046C Injection in Patients With Advanced Solid Tumors
Advanced Solid Cancer
Minghui Pharmaceutical (Hangzhou) Ltd200 enrolled1 locationNCT06985355
Recruiting
Phase 1
Study of SC-102 in Patients With Advanced Solid Tumors
Advanced Solid Cancers
Tianjin ConjuStar Biologics Co., Ltd.120 enrolled1 locationNCT06710158
Recruiting
Phase 1
A Phase Ia/ Ib Study of HS387 in Subjects With Advanced Solid Tumors
Advanced Solid Cancers
Zhejiang Hisun Pharmaceutical Co. Ltd.110 enrolled1 locationNCT07092748
Recruiting
Phase 1
Study of SYN818 for the Treatment of Advanced or Metastatic Solid Tumors
Breast CancerOvarian CancerProstate Cancer+4 more
Hangzhou SynRx Therapeutics Biomedical Technology Co., Ltd30 enrolled2 locationsNCT06666270
Recruiting
Phase 1
APG-2449 in Patients With Advanced Solid Tumors
Esophageal CancerOvarian CancerNon-small Cell Lung Cancer+2 more
Ascentage Pharma Group Inc.165 enrolled9 locationsNCT03917043
Completed
Phase 1
A phase 1 clinical trial of BIL06v/Alhydrogel to evaluate the safety, tolerability, immunogenicity and anti-tumour activity and to determine the most effective dose of BIL06v/Alhydrogel to treat patients with advanced forms of solid cancers
Advanced Solid Cancers
Biosceptre (Aust) Pty Limited30 enrolled2 locationsACTRN12618000838213