Phase 1 AF Clinical Trials
108 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 108 trials
Recruiting
Phase 1Phase 2
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
Colorectal, CancerColorectal CarcinomaNon-small Cell Lung Cancer+29 more
Institut de Recherches Internationales Servier554 enrolled27 locationsNCT05786924
Recruiting
Phase 1Phase 2
Scar Remodeling After Burn Injury Using Allogeneic Adipose-derived Stromal Cells
Scar Conditions and Fibrosis of SkinScar Quality Assessment and SafetyScar Tissue
Rigshospitalet, Denmark39 enrolled1 locationNCT07635875
Recruiting
Phase 1Phase 2
Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease
Sickle Cell DiseaseGraft FailureHematopoetic Stem Cell Transplant+2 more
Arkansas Children's Hospital Research Institute24 enrolled4 locationsNCT07252050
Recruiting
Phase 1
A Phase 1 Study of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Advanced or Metastatic Solid Tumors
Metastatic Hepatocellular CarcinomaLocal Advanced Hepatocellular CarcinomaAlpha-fetoprotein (AFP)-Producing Gastric Cancer+2 more
BeOne Medicines392 enrolled46 locationsNCT06427941
Recruiting
Phase 1Phase 2
Post-Transplant Cyclophosphamide, Bortezomib and Abatacept for the Prevention of Graft-versus-Host-Disease (GvHD)
Graft-Versus-Host Disease
Northwell Health74 enrolled1 locationNCT05289167
Recruiting
Phase 1
Bicalutamide Therapy in Young Women With NAFLD and PCOS
PCOSNAFLD
University of California, San Francisco50 enrolled1 locationNCT05979389
Recruiting
Phase 1Phase 2
Dual-Targeting CAR-NK Cells for Recurrent Ovarian Cancer (MSLN, FRα, MUC16) pt2
Primary Peritoneal CarcinomaFallopian Tube CarcinomaEpithelial Ovarian Cancer+1 more
Beijing Biotech36 enrolled1 locationNCT07617753
Recruiting
Phase 1
Evaluating the Pharmacokinetics and Safety of Miricorilant
Nonalcoholic Steatohepatitis (NASH)Non-alcoholic Fatty Liver Disease NAFLDMetabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis+1 more
Corcept Therapeutics15 enrolled1 locationNCT07553663
Recruiting
Phase 1Phase 2
Phase I/II Study of Pacritinib, A JAK2/IRAK1/CSF1R Inhibitor, in Refractory Chronic Graft-Versus-Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
Graft vs Host Disease
National Cancer Institute (NCI)50 enrolled2 locationsNCT05531786
Recruiting
Phase 1
Emapalumab With Post-Transplant Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Graft-versus-Host Disease After Donor Reduced-Intensity Hematopoietic Cell Transplant
Acute Myeloid LeukemiaMyelodysplastic SyndromeGraft-Versus-Host Disease
City of Hope Medical Center15 enrolled1 locationNCT06996119
Recruiting
Phase 1
A First in Human Study of the Safety, Tolerability, and the Physiologically Based Pharmacokinetics of XFB19 in Healthy Adult Volunteers.
Focus of the Study: Safety of XFB19
Xfibra, Inc.40 enrolled1 locationNCT05361733
Recruiting
Phase 1Phase 2
Anthocyanin-Rich Table Grape Powder for Prophylaxis of Post-Operative Atrial Fibrillation
Post-operative Atrial Fibrillation (POAF)
University of Michigan70 enrolled1 locationNCT05991700
Recruiting
Phase 1
Ruxolitinib With and Without CTLA-4 Ig Abatacept for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation
Graft vs Host DiseaseGraft-Versus-Host Disease
Washington University School of Medicine41 enrolled1 locationNCT06008808
Recruiting
Phase 1Phase 2
Safety and Efficacy of Treprostinil (Remodulin®) In Reducing Ischemia-Reperfusion Injury During Kidney Transplantation
Ischemia Reperfusion InjuryDelayed Graft Function
Rhode Island Hospital20 enrolled1 locationNCT04005469
Recruiting
Phase 1
A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors
MelanomaNSCLCSolid Tumor, Adult+6 more
Nested Therapeutics, Inc230 enrolled23 locationsNCT06326411
Recruiting
Phase 1
A Clinical Study of GenSci134 in Healthy Adults and Adult Growth Hormone Deficiency(AGHD)
SafetyTolerabilityAdult Growth Hormone Deficiency
Changchun GeneScience Pharmaceutical Co., Ltd.64 enrolled1 locationNCT07016802
Recruiting
Phase 1
Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder
SchizophreniaSchizo Affective DisorderBipolar Disorder I+2 more
BioXcel Therapeutics Inc140 enrolled5 locationsNCT05025605
Recruiting
Phase 1Phase 2
Acetazolamide for Treatment Resistant Schizophrenia
SchizophreniaSchizo Affective Disorder
Vishwajit Nimgaonkar, MD PhD60 enrolled2 locationsNCT04887792
Recruiting
Phase 1
Dabrafenib, Trametinib, and IMRT in Treating Patients With BRAF Mutated Anaplastic Thyroid Cancer
Thyroid Gland Anaplastic CarcinomaBRAF NP_004324.2:p.V600EBRAF V600K Mutation Present
City of Hope Medical Center6 enrolled3 locationsNCT03975231
Recruiting
Phase 1Phase 2
Ocrelizumab for Psychosis by Autoimmunity
SchizophreniaSchizo-Affective Type of Psychosis
The Methodist Hospital Research Institute40 enrolled1 locationNCT03971487