Phase 1 AIN Clinical Trials
269 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 269 trials
Recruiting
Phase 1
Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer
Palliative CareIntractable Pain
National Institute of Dental and Craniofacial Research (NIDCR)45 enrolled1 locationNCT00804154
Recruiting
Phase 1
Psilocybin in Chronic Low Back Pain and Depression
DepressionChronic Low-back Pain
Johns Hopkins University40 enrolled1 locationNCT06355414
Recruiting
Phase 1
Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies
Advanced Cancers (Breast, Ovarian, mCRPC, Pancreatic Ductal Adenocarcinoma (PDAC), Brain Mets) With Specific Mutations (Homologous Recombination Deficiency)
Duke Street Bio Ltd180 enrolled18 locationsNCT06458712
Recruiting
Phase 1Phase 2
Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma
Brain CancerGBMGlioma+12 more
National Institute of Neurological Disorders and Stroke (NINDS)40 enrolled1 locationNCT07416188
Recruiting
Phase 1
Simulation-Free Celiac Plexus Pain Ablation Using Stereotactic Body Radiotherapy (SBRT) in Participants With Cancer-Related Celiac Pain
Pancreatic CancerRetroperitoneal Pain Syndrome
Case Comprehensive Cancer Center5 enrolled1 locationNCT07117032
Recruiting
Phase 1
Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain Tumors
Primary Brain Neoplasm
M.D. Anderson Cancer Center13 enrolled1 locationNCT03830151
Recruiting
Phase 1Phase 2
Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
Colorectal, CancerEsophageal CancerGastric Cancer+18 more
Neonc Technologies, Inc.134 enrolled7 locationsNCT06047379
Recruiting
Phase 1
Impact of Daily Oral Cannabis Doses in Patients With Cancer
CancerCancers, Pain
Shanna Babalonis, PhD80 enrolled1 locationNCT06601218
Recruiting
Phase 1
Clinical Efficacy of Antivet Versus Phosphoric Acid and Hydrochloric Acid in Microabrasion
Teeth Staining
Misr University for Science and Technology60 enrolled1 locationNCT07709286
Recruiting
Phase 1
Study Evaluating the Safety, Efficacy and Pharmacokinetics of SYH9089 Injection in Patients Undergoing Abdominal Surgery.
Postoperative Pain
CSPC Ouyi Pharmaceutical Co., Ltd.60 enrolled1 locationNCT07519109
Recruiting
Phase 1Phase 2
Intraperitoneal Irrigation of Ondansteron in Combination With Lidocaine in Acute Postoperative Pain
Acue Postoperative Pain
Assiut University20 enrolled1 locationNCT07706348
Recruiting
Phase 1
Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury
Spinal StenosisDegenerative Disc DiseaseSpinal Cord Injuries+2 more
EicOsis Human Health Inc.36 enrolled1 locationNCT06438471
Recruiting
Phase 1
A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors
MelanomaNon-small Cell Lung CancerThyroid Cancer+10 more
Pfizer124 enrolled83 locationsNCT05538130
Recruiting
Phase 1Phase 2
Vasopressin and Pain Perception in the Brain
Acute Pain
University of Maryland, Baltimore56 enrolled1 locationNCT03446456
Recruiting
Phase 1Phase 2
Accelerated rTMS vs. Sham for Stroke Apathy
StrokeMotivationApathy+4 more
Medical University of South Carolina40 enrolled1 locationNCT07113067
Recruiting
Phase 1
A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis
Relapsed or Refractory Multiple MyelomaPreviously Treated Amyloid Light-chain (AL) Amyloidosis
Janssen Research & Development, LLC180 enrolled29 locationsNCT05652335
Recruiting
Phase 1Phase 2
A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.
AmyloidosisLight Chain AmyloidosisRelapsed AL Amyloidosis+1 more
Alexion Pharmaceuticals, Inc.91 enrolled18 locationsNCT07081646
Recruiting
Phase 1
Stereotactic Radiosurgery Dose Escalation for Brain Metastases
Brain Metastases
University of Utah86 enrolled1 locationNCT02390518
Recruiting
Phase 1Phase 2
Assessing Changes in Multi-parametric MRI in MS Patients Taking Clemastine Fumarate as a Myelin Repair Therapy
Multiple Sclerosis (MS)Multiple Sclerosis, Relapsing-RemittingMultiple Sclerosis, Primary Progressive+4 more
University of California, San Francisco74 enrolled1 locationNCT05359653
Recruiting
Phase 1Phase 2
Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas
OsteosarcomaEwing SarcomaNeuroblastoma+4 more
Milton S. Hershey Medical Center289 enrolled12 locationsNCT06465199