Phase 1 AIN Clinical Trials
255 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 255 trials
Recruiting
Phase 1Phase 2
Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma
Brain CancerGBMGlioma+12 more
National Institute of Neurological Disorders and Stroke (NINDS)40 enrolled1 locationNCT07416188
Recruiting
Phase 1
A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors
MelanomaNon-small Cell Lung CancerThyroid Cancer+10 more
Pfizer124 enrolled79 locationsNCT05538130
Recruiting
Phase 1Phase 2
Assessment of the Efficacy and Safety of Injectable TQB2934 (Subcutaneous Injection) in Systemic Light Chain Amyloidosis Patients
Systemic Light Chain Amyloidosis
Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.70 enrolled27 locationsNCT07266116
Recruiting
Phase 1
A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis
Relapsed or Refractory Multiple MyelomaPreviously Treated Amyloid Light-chain (AL) Amyloidosis
Janssen Research & Development, LLC180 enrolled29 locationsNCT05652335
Recruiting
Phase 1
STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis
Pancreatic SurgeryChronic PainChronic Pancreatitis+7 more
Indiana University24 enrolled5 locationsNCT05603702
Recruiting
Phase 1Phase 2
Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study
Tumors Metastatic to Brain
Case Comprehensive Cancer Center36 enrolled2 locationsNCT01891318
Recruiting
Phase 1
Stereotactic Radiosurgery Dose Escalation for Brain Metastases
Brain Metastases
University of Utah50 enrolled1 locationNCT02390518
Recruiting
Phase 1Phase 2
A Rollover Study of NBM-BMX in Combination With Temozolomide in Patients With Newly Diagnosed Glioblastoma
Malignant Neoplasm of Brain
Novelwise Pharmaceutical Corporation15 enrolled3 locationsNCT07569042
Recruiting
Phase 1
Safety Study of the Repeated Opening of the Blood-brain Barrier With the SonoCloud® Device to Treat Malignant Brain Tumors in Pediatric Patients
Malignant GliomaMalignant Brain TumorEmbryonal Tumor
Assistance Publique - Hôpitaux de Paris24 enrolled3 locationsNCT05293197
Recruiting
Phase 1
Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer
Palliative CareIntractable Pain
National Institute of Dental and Craniofacial Research (NIDCR)45 enrolled1 locationNCT00804154
Recruiting
Phase 1Phase 2
A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations
CancerBrain Tumor
National Cancer Institute (NCI)96 enrolled1 locationNCT05588141
Recruiting
Phase 1Phase 2
Cannabidiol for the Treatment of Diabetic Peripheral Neuropathy: Pilot Study
Diabetic NeuropathiesDiabetic Peripheral Neuropathic Pain (DPN)
Florida A&M University20 enrolled1 locationNCT07298408
Recruiting
Phase 1Phase 2
Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
Hypoxia, BrainBlood PressureStroke+5 more
University of Calgary12 enrolled1 locationNCT03255408
Recruiting
Phase 1
A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma
GlioblastomaGliomaGlioblastoma Multiforme of Brain
Tetragon Biosciences Ltd30 enrolled3 locationsNCT07464925
Recruiting
Phase 1
Efficacy and Safety of Autologous Peptide-induced Active Immunity in AML Maintenance Therapy
Acute Myeloid LeukemiaMaintenance TherapyPersonalized Active Immunotherapy
Fujian Medical University Union Hospital90 enrolled1 locationNCT07551037
Recruiting
Phase 1Phase 2
Safety and Tolerability Study of ST-503 for Refractory Pain Due to Peripheral Neuropathy (Small Fiber Predominant, SFN)
Chronic Neuropathic Pain
Sangamo Therapeutics27 enrolled11 locationsNCT06980948
Recruiting
Phase 1Phase 2
NBM-BMX Administered Orally to Patients With Solid Tumors or Newly Diagnosed Glioblastoma
Malignant NeoplasmMalignant Neoplasm of Brain
Novelwise Pharmaceutical Corporation79 enrolled4 locationsNCT06012695
Recruiting
Phase 1Phase 2
A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis)
Relapsed/Refractory Systemic Light Chain Amyloidosis
Regeneron Pharmaceuticals220 enrolled19 locationsNCT06292780
Recruiting
Phase 1
The Safety/Efficacy Study of Human Umbilical Cord Mesenchymal Stem Cells Therapy (19#iSCLife®-LDP) for Lumbar Discogenic Pain
Lumbar Discogenic Pain
Sclnow Biotechnology Co., Ltd.242 enrolled1 locationNCT04104412
Recruiting
Phase 1
Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery
Brain Metastases, AdultBrain MetastasesBrain Cancer
Baptist Health South Florida20 enrolled1 locationNCT04689048