Phase 1 Amyotrophic Lateral Sclerosis Clinical Trials
22 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 22 trials
Recruiting
Phase 1Phase 2
A Clinical Trial to Evaluate NB-4746 in Participants With Amyotrophic Lateral Sclerosis.
Amyotrophic Lateral Sclerosis(ALS)
Nura Bio80 enrolled6 locationsNCT07369076
Recruiting
Phase 1
A Study to Investigate the Safety and Pharmacodynamics of a Single Intrathecal Injection (IT) of INS1202 in Participants With Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral Sclerosis
Insmed Gene Therapy LLC23 enrolled5 locationsNCT07290062
Recruiting
Phase 1Phase 2
Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS
Amyotrophic Lateral Sclerosis
Vector Y Therapeutics12 enrolled11 locationsNCT07287397
Recruiting
Phase 1Phase 2
TP04HN106 in the Treatment of Patients With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Talengen Institute of Life Sciences, Shenzhen, P.R. China.60 enrolled1 locationNCT06726577
Recruiting
Phase 1Phase 2
Intestinal Microbiome Transplant in ALS
Amyotrophic Lateral Sclerosis(ALS)
Duke University20 enrolled1 locationNCT07017946
Not Yet Recruiting
Phase 1
A study to assess safety, tolerability and pharmacokinetics of RTX-010/101/111 for participants with C9orf72-mediated Amyotrophic Lateral Sclerosis (ALS). Part 1C adults with C9orf72-mediated ALS only.
C9orf72-mediated Amyotrophic Lateral Sclerosis (ALS)
Repeat Therapeutics Pty Ltd16 enrolled1 locationACTRN12626000385347
Recruiting
Phase 1
A Study of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis
ALS (Amyotrophic Lateral Sclerosis)
Eli Lilly and Company32 enrolled12 locationsNCT07100119
Recruiting
Phase 1
Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Amisodin in Healthy Adult Subjects With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
PRG Science & Technology Co., Ltd.48 enrolled1 locationNCT07221240
Recruiting
Phase 1Phase 2
First in Human (FIH) Study of ALN-SOD in Adult Participants With Amyotrophic Lateral Sclerosis Associated With Mutation in the SOD1 Gene (SOD1-ALS)
Amyotrophic Lateral Sclerosis(ALS)Mutation in the Superoxide Dismutase-1 (SOD1) Gene
Regeneron Pharmaceuticals42 enrolled16 locationsNCT06351592
Recruiting
Phase 1Phase 2
Evaluation of the Combined Therapy of EH-301 and N-acetylcysteine Together With Riluzole in Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral Sclerosis
Biogipuzkoa Health Research Institute90 enrolled1 locationNCT07414212
Recruiting
Phase 1
Safety and Tolerability Study of CTx1000 In Participants With Amyotrophic Lateral Sclerosis
ALS (Amyotrophic Lateral Sclerosis)
Celosia Therapeutics Pty Ltd15 enrolled1 locationNCT07401121
Recruiting
Phase 1
The Safety, Tolerability and Preliminary Efficacy of Derived Motor Neuron Progenitor Cells (XS228CN) in Subjects With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis(ALS)
XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.12 enrolled1 locationNCT07118319
Recruiting
Phase 1
A study to assess safety, tolerability, and pharmacokinetics of RTX-010/101/111 in healthy adults. Part 1A and Part B healthy participants only
Amyotrophic Lateral Sclerosis
Repeat Therapeutics Pty Ltd104 enrolled1 locationACTRN12625001215415
Recruiting
Phase 1
Clinical Study of Regulatory T Cells (Tregs) in the Treatment of Neurodegenerative Diseases
Amyotrophic Lateral Sclerosis(ALS)
Novabio Therapeutics12 enrolled1 locationNCT06671236
Recruiting
Phase 1
Intravenous Immunoglobulin (IVIG) and Blood-Brain Barrier Disruption in Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral SclerosisALS
Sunnybrook Health Sciences Centre6 enrolled1 locationNCT07193953
Recruiting
Phase 1Phase 2
Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers
Amyotrophic Lateral Sclerosis(ALS)Alzheimer Disease (AD)Parkinson Disease (PD)+1 more
Ashvattha Therapeutics, Inc.65 enrolled3 locationsNCT05395624
Recruiting
Phase 1
A Study to Evaluate the Safety and Pharmacokinetics of Single and Multiple Doses of Prosetin in Healthy Volunteers and Participants With ALS
Amyotrophic Lateral Sclerosis
ProJenX72 enrolled4 locationsNCT05279755
Recruiting
Phase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RAG-17 in Subjects With Amyotrophic Lateral Sclerosis (ALS) With Superoxide Dismutase Type 1 (SOD1) Gene Mutation
Amyotrophic Lateral Sclerosis
Ractigen Therapeutics.32 enrolled3 locationsNCT06556394
Recruiting
Phase 1
A Phase 1, SAD and MAD Study to Evaluate the Safety and Tolerability of FB418
Amyotrophic Lateral Sclerosis(ALS)Parkinson Disease Psychosis
1ST Biotherapeutics, Inc.64 enrolled1 locationNCT05995782
Recruiting
Phase 1Phase 2
Exploring Nasal Drop Therapy With Small Extracellular Vesicles for ALS
Amyotrophic Lateral Sclerosis
Xuanwu Hospital, Beijing38 enrolled1 locationNCT06598202