Phase 2 Amyotrophic Lateral Sclerosis Clinical Trials
29 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 29 trials
Recruiting
Phase 2Phase 3
HD-tDCS in Amyotrophic Lateral Sclerosis: A Multicenter Randomized Controlled Trial
Amyotrophic Lateral Sclerosis(ALS)
Universidade Federal do Rio Grande do Norte80 enrolled4 locationsNCT06719947
Recruiting
Phase 1Phase 2
A Clinical Trial to Evaluate NB-4746 in Participants With Amyotrophic Lateral Sclerosis.
Amyotrophic Lateral Sclerosis(ALS)
Nura Bio80 enrolled6 locationsNCT07369076
Recruiting
Phase 2
A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)
Chronic respiratory failureNon-invasive ventilationRespiratory Insufficiency+7 more
University of Pennsylvania48 enrolled3 locationsNCT07071935
Recruiting
Phase 2
Dazucorilant in Patients With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Corcept Therapeutics279 enrolled35 locationsNCT05407324
Recruiting
Phase 2
Tofersen in Non-SOD1 ALS
ALS (Amyotrophic Lateral Sclerosis)
Washington University School of Medicine30 enrolled2 locationsNCT07294144
Recruiting
Phase 2
PHENOGENE-1A (Cromolyn) Treatment in Patients With Mild to Moderate ALS
Amyotrophic Lateral Sclerosis(ALS)
PhenoNet, Inc.105 enrolled20 locationsNCT07142291
Recruiting
Phase 1Phase 2
Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS
Amyotrophic Lateral Sclerosis
Vector Y Therapeutics12 enrolled11 locationsNCT07287397
Recruiting
Phase 2
A Study of Ranolazine in ALS
Amyotrophic Lateral Sclerosis
Swathy Chandrashekhar, MBBS72 enrolled6 locationsNCT06527222
Recruiting
Phase 2Phase 3
HEALEY ALS Platform Trial - Master Protocol
Amyotrophic Lateral Sclerosis
Merit E. Cudkowicz, MD1,500 enrolled81 locationsNCT04297683
Recruiting
Phase 2
Study of COYA 302 for the Treatment of ALS
Amyotrophic Lateral Sclerosis(ALS)
Coya Therapeutics120 enrolled25 locationsNCT07161999
Recruiting
Phase 2
Psilocybin Therapy for Psychological Distress in Palliative Patients
COPD, Chronic Obstructive Pulmonary DiseaseMajor Depressive Disorder (MDD)ALS (Amyotrophic Lateral Sclerosis)+2 more
University Medical Center Groningen108 enrolled4 locationsNCT06782724
Recruiting
Phase 1Phase 2
TP04HN106 in the Treatment of Patients With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Talengen Institute of Life Sciences, Shenzhen, P.R. China.60 enrolled1 locationNCT06726577
Recruiting
Phase 1Phase 2
Intestinal Microbiome Transplant in ALS
Amyotrophic Lateral Sclerosis(ALS)
Duke University20 enrolled1 locationNCT07017946
Recruiting
Phase 2Phase 3
Motor Neurone Disease - Systematic Multi-Arm Adaptive Randomised Trial
Motor Neuron Disease / Amyotrophic Lateral Sclerosis
University of Edinburgh1,150 enrolled22 locationsNCT04302870
Recruiting
Phase 1Phase 2
First in Human (FIH) Study of ALN-SOD in Adult Participants With Amyotrophic Lateral Sclerosis Associated With Mutation in the SOD1 Gene (SOD1-ALS)
Amyotrophic Lateral Sclerosis(ALS)Mutation in the Superoxide Dismutase-1 (SOD1) Gene
Regeneron Pharmaceuticals42 enrolled16 locationsNCT06351592
Recruiting
Phase 1Phase 2
Evaluation of the Combined Therapy of EH-301 and N-acetylcysteine Together With Riluzole in Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral Sclerosis
Biogipuzkoa Health Research Institute90 enrolled1 locationNCT07414212
Recruiting
Phase 2Phase 3
Trial on the Biological and Clinical Effects of Acetyl-L-carnitine in ALS
Amyotrophic Lateral Sclerosis
Mario Negri Institute for Pharmacological Research246 enrolled19 locationsNCT06126315
Recruiting
Phase 2
A Study to Assess the Safety, Tolerability, and Pharmacology of Darifenacin in Patients With ALS
Amyotrophic Lateral Sclerosis
Oliver Blanchard30 enrolled2 locationsNCT06249867
Recruiting
Phase 2
Mitochondrial Capacity Boost in ALS (MICABO-ALS) Trial
Amyotrophic Lateral Sclerosis(ALS)
Dallas VA Medical Center60 enrolled1 locationNCT04244630
Recruiting
Phase 2Phase 3
RAPA-501 Therapy for ALS
Amyotrophic Lateral Sclerosis
Rapa Therapeutics LLC41 enrolled1 locationNCT04220190