ankle sprains Clinical Trials

12 recruitingLast updated: May 11, 2026

There are 12 actively recruiting ankle sprains clinical trials across 9 countries. Studies span Not Applicable. Top locations include Lexington, Kentucky, United States, Beijing, China, Belo Horizonte, Minas Gerais, Brazil. Updated daily from ClinicalTrials.gov.


ankle sprains Trials at a Glance

12 actively recruiting trials for ankle sprains are listed on ClinicalTrialsFinder across 6 cities in 9 countries. The largest study group is Not Applicable with 8 trials, with the heaviest enrollment activity in Lexington, Beijing, and Belo Horizonte. Lead sponsors running ankle sprains studies include Cairo University, Peking University Third Hospital, and Centre Hospitalier Universitaire de Saint Etienne.

Browse ankle sprains trials by phase

Treatments under study

About ankle sprains Clinical Trials

Looking for clinical trials for ankle sprains? There are currently 11 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new ankle sprains trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about ankle sprains clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 112 of 12 trials

Recruiting
Not Applicable

Investigating the Effects of Cognitive Functional Therapy on Pain, Physical Function, and Kinesiophobia in Individuals With Chronic Ankle Sprain

Chronic Ankle SprainChronic Ankle Sprains
Yeditepe University40 enrolled1 locationNCT07449078
Recruiting
Not Applicable

Addressing Neuromuscular Deficits for Improved Outcomes in Ankle Rehabilitation

ankle sprains
Phillip Gribble150 enrolled2 locationsNCT03663361
Recruiting
Not Applicable

Auditory Biofeedback Gait Training Individuals With Chronic Ankle Instability

ankle sprainsAnkle Injuries and Disorders
University of Kentucky100 enrolled2 locationsNCT06868316
Recruiting

Comparison of MBR + Suture Tape, MBR, and Anatomic Reconstruction for CLAI in GJL Cases: A Prospective Cohort Study

ankle sprainsHypermobility Syndrome
Peking University Third Hospital114 enrolled1 locationNCT05698446
Recruiting

The Clinical Outcomes of the Modified Broström vs Anatomic Reconstruction Operation in CLAI and GJL

ankle sprainsJoint HypermobilityInstability, Joint
Peking University Third Hospital100 enrolled1 locationNCT05196906
Recruiting
Not Applicable

Spinal and Supraspinal Control in Chronic Ankle Instability

Ankle injuriesankle sprains
Ayca Yagcioglu30 enrolled2 locationsNCT06898554
Recruiting
Not Applicable

Effect of ACL Reconstruction in Biomechanical Properties of Ankle Joint Complex

ankle sprainsAnterior Cruciate Ligament tear
Cairo University40 enrolled1 locationNCT06631690
Recruiting
Not Applicable

Arthroscopic Versus Open Brostrom for Ankle Instability

ankle sprainsSurgeryLigament Injury+1 more
Federal University of São Paulo98 enrolled2 locationsNCT03643926
Recruiting
Not Applicable

A Mobile Recovery Guidance App for Children and Young Adults With Acute Ankle Inversion Injuries

ankle sprains
Naveen Poonai250 enrolled1 locationNCT05785533
Recruiting

Interest of Ultrasound in the Diagnosis of Severity of Lateral Ankle Sprain

ankle sprains
Centre Hospitalier Universitaire de Saint Etienne50 enrolled1 locationNCT04846712
Recruiting
Not Applicable

The Effect of Taping on Plantar Pressure Distribution in Players With Chronic Ankle Instability

Ankle injuriesankle sprainsAnkle Injuries and Disorders
Cairo University88 enrolled1 locationNCT06499935
Recruiting

The effect of talocrural mobilisation with movement on ankle dorsiflexion and knee valgus during squatting in individuals with a history of ankle sprains

History of lateral ankle sprainsDecreased dorsiflexion range of motion
University of Queensland20 enrolled1 locationACTRN12614000981628