Phase 1 ART Clinical Trials
325 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 325 trials
Recruiting
Phase 1
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
Malignant Solid NeoplasmHematopoietic and Lymphoid Cell NeoplasmRheumatoid Arthritis+11 more
National Cancer Institute (NCI)300 enrolled52 locationsNCT03816345
Recruiting
Phase 1
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions and Subcutaneous Injections of ABBV-519 in Adult Participants With Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA)
Rheumatoid ArthritisSystemic Lupus Erythematosus
AbbVie30 enrolled6 locationsNCT07607964
Recruiting
Phase 1Phase 2
A Phase I Study of Mozobil in the Treatment of Patients With WHIMS
NeutropeniaInfectionsWarts+2 more
National Institute of Allergy and Infectious Diseases (NIAID)20 enrolled1 locationNCT00967785
Recruiting
Phase 1
A Study to Investigate the Effect of AZD6234, AZD9550, and a Combination of AZD9550 and AZD6234 on Pharmacokinetics of Combined Oral Contraceptive Ethinyl Estradiol/Levonorgestrel in Healthy Female Participants Living With Overweight or Obesity
Healthy Participants
AstraZeneca50 enrolled2 locationsNCT07013643
Recruiting
Phase 1
A Study to See How RO7763505 Works and How Safe it is When Given to Healthy People and People With Stable Heart Disease
stable coronary artery diseaseHealthy Volunteers
Hoffmann-La Roche196 enrolled1 locationNCT07495813
Recruiting
Phase 1Phase 2
CD19-Directed Chimeric Antigen Receptor Autologous T Cells (CART19) for Lupus
CAR-T CellSLESystemic Lupus Erythematosus (SLE)+4 more
Children's Hospital of Philadelphia24 enrolled1 locationNCT06839976
Recruiting
Phase 1
R-2487 in Patients With Rheumatoid Arthritis
Arthritis, Rheumatoid
Rise Therapeutics LLC73 enrolled6 locationsNCT05961592
Recruiting
Phase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.
ObesityHealthy Participants
AstraZeneca104 enrolled3 locationsNCT07511205
Recruiting
Phase 1
Study of GS-0151 in Participants With Rheumatoid Arthritis
Rheumatoid Arthritis
Gilead Sciences75 enrolled35 locationsNCT06902519
Recruiting
Phase 1
A Study of NHL907 in Healthy Adult Participants
healthy adult participants
NeuHyll AUS Pty Ltd64 enrolled1 locationNCT07580924
Recruiting
Phase 1
A Study to Assess the Effect of AZD0780 on the Pharmacokinetics of AZD4954 and Vice Versa in Healthy Adults
Healthy Participants
AstraZeneca32 enrolled1 locationNCT07513571
Recruiting
Phase 1
Healthy Participants Randomized, Double-blind, Placebo-controlled, Phase Ⅰ
Healthy Participants Study
First Affiliated Hospital of Zhejiang University104 enrolled1 locationNCT07640438
Recruiting
Phase 1
A Clinical Study of MK-1045 in People With Lupus or Rheumatoid Arthritis (MK-1045-004)
Rheumatoid ArthritisSystemic Lupus Erythematosus
Merck Sharp & Dohme LLC21 enrolled15 locationsNCT07363590
Recruiting
Phase 1
A Study to Evaluate the Safety, Tolerability, and Drug Levels of BMS-986454 in Participants With Rheumatoid Arthritis
Rheumatoid Arthritis
Bristol-Myers Squibb46 enrolled9 locationsNCT07171983
Recruiting
Phase 1
A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults
Psoriatic ArthritisAxial Spondyloarthritis
UCB Biopharma SRL392 enrolled61 locationsNCT07290036
Recruiting
Phase 1
GCAR1, a Chimeric Antigen Receptor (CAR) T-CELL Therapy for Relapsed/Refractory GPNMB-Expressing Solid Tumours
Triple-Negative Breast CancerRenal Cell CarcinomaAlveolar Soft Part Sarcoma
Canadian Cancer Trials Group30 enrolled1 locationNCT07297667
Recruiting
Phase 1
A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.
MelanomaNon-small Cell Lung CancerThyroid Cancer+2 more
Pfizer267 enrolled40 locationsNCT05355701
Recruiting
Phase 1
Study of Intravenous ZMA001 in Healthy Subjects
Pulmonary Arterial Hypertension PAH
National Heart, Lung, and Blood Institute (NHLBI)96 enrolled1 locationNCT05967299
Recruiting
Phase 1
Evaluate the Effect of Vimseltinib on Pharmacokinetics of Combined Oral Contraceptive (Ethinyl Estradiol/Levonorgestrel)
Healthy Participants
Deciphera Pharmaceuticals, LLC24 enrolled1 locationNCT07539090
Recruiting
Phase 1
A Trial to Compare the Pharmacokinetics of Two Presentations of Navenibart in Healthy Participants
healthy adult participants
Astria Therapeutics, Inc.180 enrolled3 locationsNCT07635095