Phase 2 Astrocytoma Clinical Trials
20 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 20 trials
Recruiting
Phase 1Phase 2
A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma
Glioblastoma IDH (Isocitrate Dehydrogenase) WildtypeAstrocytoma, Grade III
Debiopharm International SA116 enrolled17 locationsNCT05765812
Recruiting
Phase 2
Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
Metastatic Brain TumorGlioblastomaGlioblastoma Multiforme+7 more
Nationwide Children's Hospital120 enrolled21 locationsNCT05843253
Recruiting
Phase 2
Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA
Brain TumorBrain CancerGlioblastoma+6 more
Northwell Health37 enrolled1 locationNCT02800486
Recruiting
Phase 2
Tuvusertib in Astrocytoma With ATRX Mutation
Astrocytoma
Grupo Español de Investigación en Neurooncología56 enrolled10 locationsNCT07417761
Recruiting
Phase 1Phase 2
HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM
Glioblastoma MultiformeAstrocytoma, Grade III
David Baskin MD62 enrolled1 locationNCT03596086
Recruiting
Phase 1Phase 2
HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM
GlioblastomaAnaplastic Astrocytoma
The Methodist Hospital Research Institute62 enrolled1 locationNCT03603405
Recruiting
Phase 1Phase 2
Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
Cervical CancerBrain Metastases, AdultDiffuse Astrocytoma, IDH-Mutant+1 more
Neonc Technologies, Inc.134 enrolled6 locationsNCT06047379
Recruiting
Phase 2
All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma
GliomaOligodendrogliomaAstrocytoma+1 more
Stephen Bagley, MD, MSCE55 enrolled1 locationNCT05345002
Recruiting
Phase 2
Venous Thromboembolism Prevention in Outpatients With Glioma
GlioblastomaVenous ThromboembolismAstrocytoma
University of Vermont Medical Center40 enrolled1 locationNCT05683808
Recruiting
Phase 1Phase 2
Study of Pembrolizumab and M032 (NSC 733972)
Glioblastoma MultiformeAnaplastic AstrocytomaGliosarcoma
University of Alabama at Birmingham28 enrolled1 locationNCT05084430
Recruiting
Phase 1Phase 2
5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours
Glioblastoma Multiforme (GBM)Malignant Primary GliomasGlioblastoma Multiform (Grade IV Astrocytoma)+1 more
Institute of Cancer Research, United Kingdom182 enrolled3 locationsNCT06630260
Recruiting
Phase 2
Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas
GlioblastomaOligodendrogliomaWHO Grade III Glioma+6 more
M.D. Anderson Cancer Center40 enrolled1 locationNCT04623931
Recruiting
Phase 1Phase 2
Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age
Glioblastoma MultiformeOligodendrogliomaDiffuse Intrinsic Pontine Glioma+5 more
University of Miami20 enrolled1 locationNCT05956821
Recruiting
Phase 2
Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy
Pleomorphic XanthoastrocytomaGrade 1 GliomaMixed Glio-neuronal Tumors
University Hospital, Strasbourg, France134 enrolled25 locationsNCT05180825
Recruiting
Phase 2
DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma
High Grade GliomaAnaplastic Astrocytoma
Ashish Shah33 enrolled1 locationNCT06264388
Recruiting
Phase 1Phase 2
Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA
Glioblastoma MultiformeAnaplastic Astrocytoma
Northwell Health54 enrolled1 locationNCT01269853
Recruiting
Phase 2
Study of Olutasidenib and Temozolomide in HGG
Metastatic Brain TumorIDH1 MutationAstrocytoma, Grade IV+16 more
Rigel Pharmaceuticals60 enrolled18 locationsNCT06161974
Recruiting
Phase 1Phase 2
T Cells and Pembrolizumab for Recurrent and Newly Diagnosed Glioblastoma
Glioblastoma MultiformeAstrocytoma, Grade IV
Queensland Institute of Medical Research58 enrolled4 locationsNCT06157541
Recruiting
Phase 2
T cells and pembrolizumab for recurrent and newly diagnosed glioblastoma
Glioblastoma multiforme/astrocytoma grade 4
QIMR Berghofer Medical Research Institute58 enrolled1 locationACTRN12623001126606
Completed
Phase 2
A Randomised Phase II Study of NivolUmab and TeMozolomide vs Temozolomide alone in newly diagnosed Elderly patients with Glioblastoma (NUTMEG)
Glioblastoma (GBM, astrocytoma WHO grade IV)
The University of Sydney102 enrolled18 locationsACTRN12617000267358