Phase 1 Atrophy Clinical Trials
32 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 32 trials
Recruiting
Phase 1
Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ION464 Administered to Adults With Multiple System Atrophy (HORIZON)
Multiple System Atrophy
Ionis Pharmaceuticals, Inc.40 enrolled15 locationsNCT04165486
Recruiting
Phase 1
Intravitreal (IVT) Pozelimab for Geographic Atrophy (GA) in Adult Participants
Geographic Atrophy (GA)
Regeneron Pharmaceuticals54 enrolled5 locationsNCT07230834
Recruiting
Phase 1Phase 2
A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
Geographic Atrophy
Sanofi104 enrolled17 locationsNCT07215234
Recruiting
Phase 1
A Phase I/III Clinical Study to Evaluate NouvNeu001 Injection for Multiple System Atrophy
Multiple System Atrophy - Parkinsonian Subtype (MSA-P)
iRegene Therapeutics Co., Ltd.9 enrolled1 locationNCT07289477
Recruiting
Phase 1Phase 2
Safety of Single and Repeat Dose of PYC-001 Eye Injections in People With Autosomal Dominant Optic Atrophy (Myrtle)
Autosomal Dominant Optic AtrophyOPA1 Gene MutationHereditary Optic Atrophies+1 more
PYC Therapeutics18 enrolled3 locationsNCT06970106
Recruiting
Phase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Immunogenicity of RO7669330 in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)
Geographic Atrophy
Hoffmann-La Roche132 enrolled16 locationsNCT06961370
Recruiting
Phase 1
Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies
Multiple System AtrophyParkinsons Disease
Craig van Horne, MD, PhD7 enrolled1 locationNCT06683365
Recruiting
Phase 1
A Study to Find Out How Nusinersen is Processed in the Body When Given Through the ThecaFlex DRx™ System in Adult and Pediatric Participants With Spinal Muscular Atrophy (PIERRE-PK)
Muscular Atrophy, Spinal
Biogen58 enrolled19 locationsNCT06555419
Not Yet Recruiting
Phase 1
A Study to Assess the Effect of Acid-Reducing Medicines on ATH434 in Healthy Volunteers
Multiple System Atrophy (MSA)
Alterity Therapeutics Limited12 enrolled1 locationACTRN12626000320358
Recruiting
Phase 1
[18F]F-DOPA Imaging in Patients With Autonomic Failure
Multiple System AtrophyParkinson DiseaseDementia With Lewy Bodies+2 more
Daniel Claassen40 enrolled1 locationNCT04246437
Recruiting
Phase 1Phase 2
Study of Safety, Tolerability and Efficacy of GB221 in Infants With Spinal Muscular Atrophy Type 1
Spinal Muscular Atrophy Type I
Gemma Biotherapeutics22 enrolled1 locationNCT07070999
Recruiting
Phase 1Phase 2
Study to Assess the Adverse Events and How Intravitreal ABBV-6628 Moves Through the Body of Adult Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
Geographic AtrophyAge-Related Macular Degeneration
AbbVie66 enrolled4 locationsNCT07160179
Recruiting
Phase 1Phase 2
Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Geographic Atrophy Associated With Age-Related Macular Degeneration
Geographic AtrophyDry Age-Related Macular Degeneration
National Eye Institute (NEI)20 enrolled2 locationsNCT04339764
Recruiting
Phase 1Phase 2
Feasibility Study Assessing the Effect of Carbidopa/Levodopa Ratio on Orthostatic Hypotension in Multiple System Atrophy - Parkinsonian Type and Parkinson Disease.
Parkinson DiseaseOrthostatic Hypotension, DysautonomicMulti-system Atrophy - Parkinsonian Type
Julien Bally36 enrolled2 locationsNCT06831500
Recruiting
Phase 1Phase 2
A Phase 1/2 Study to Evaluate the Safety and Efficacy of Intravitreal Administration of BS01 in Patients With Geographic Atrophy Secondary to Dry AMD
Geographic Atrophy (GA) Secondary to Dry Age-related Macular Degeneration (AMD)
Bionic Sight LLC40 enrolled1 locationNCT07158775
Recruiting
Phase 1
Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure
Multiple System AtrophyAutonomic FailurePure Autonomic Failure+1 more
Vanderbilt University Medical Center29 enrolled1 locationNCT02429557
Recruiting
Phase 1
AD-SVF Therapy for Refractory Endometrial Infertility
Endometrium; AtrophyIntrauterine Synechiae
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School10 enrolled1 locationNCT07230600
Recruiting
Phase 1Phase 2
Automated Abdominal Binder for Orthostatic Hypotension
Multiple System AtrophyAutonomic FailurePure Autonomic Failure+1 more
Vanderbilt University Medical Center31 enrolled1 locationNCT03482297
Recruiting
Phase 1Phase 2
Safety and Tolerability of IMM01-STEM in Patients With Muscle Atrophy Related to Knee Osteoarthritis.
Muscle Atrophy
Immunis, Inc.28 enrolled2 locationsNCT05211986
Recruiting
Phase 1Phase 2
Study of VOY-101 in Patients With Advanced Non-Neovascular Age-Related Macular Degeneration
Geographic AtrophyAge-Related Macular DegenerationNon-neovascular AMD
Perceive Biotherapeutics, Inc.60 enrolled11 locationsNCT06087458