Phase 1 Autoimmune Disease Clinical Trials
21 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 21 trials
Recruiting
Phase 1
A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases
Refractory Autoimmune Diseases
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company125 enrolled28 locationsNCT07115745
Recruiting
Phase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single- and Multiple-Ascending Doses and Food Effect of BGB-45035 in Healthy Participants and in Adults With Autoimmune Dermatological Diseases
Healthy ParticipantsHealthy VolunteersAutoimmune Diseases+1 more
BeiGene211 enrolled13 locationsNCT06342713
Recruiting
Phase 1Phase 2
Autoimmune Disease Treatment With Mesenchymal Stem Cells (MSCs) and CAR-T Cells
Autoimmune Diseases
Shenzhen Geno-Immune Medical Institute30 enrolled1 locationNCT06435897
Recruiting
Phase 1
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
Malignant Solid NeoplasmHematopoietic and Lymphoid Cell NeoplasmRheumatoid Arthritis+11 more
National Cancer Institute (NCI)300 enrolled52 locationsNCT03816345
Recruiting
Phase 1
A Study of Safety, Tolerability, PK, and PD of Subcutaneous GenSci136 in Healthy Adults.
Autoimmune Disease
Changchun GeneScience Pharmaceutical Co., Ltd.48 enrolled1 locationNCT07366866
Recruiting
Phase 1Phase 2
Anti-CD19 Chimeric Antigen Receptor T Cells for Refractory Autoimmune Diseases
Autoimmune Diseases
Beijing GoBroad Hospital18 enrolled1 locationNCT06688799
Recruiting
Phase 1Phase 2
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
Metabolic DiseaseDiabetes Mellitus, Type 1Type 1 Diabetes+14 more
Otsuka Pharmaceutical Factory, Inc.13 enrolled1 locationNCT06575426
Recruiting
Phase 1
A Phase 1 Study of Anitocabtagene Autoleucel for the Treatment of Subjects With Non-oncology Plasma Cell-related Diseases
Myasthenia GravisMuscle WeaknessAutoimmune Diseases+4 more
Arcellx, Inc.30 enrolled13 locationsNCT06626919
Recruiting
Phase 1
CAR T-cell Therapy Targeting CD19 and BCMA in Patients With B Cell Mediated Autoimmune Disease
IgA Nephropathy (IgAN)Autoimmune DiseasesSystemic Sclerosis (SSc)+3 more
The Children's Hospital of Zhejiang University School of Medicine15 enrolled1 locationNCT07305116
Not Yet Recruiting
Phase 1
A Drug-drug Interaction Study of JNJ-90858638 in Healthy Participants (Part 3 and 4: Drug-drug Interaction)
Autoimmune Disease
Janssen Research & Development, LLC40 enrolled1 locationACTRN12626000105347
Not Yet Recruiting
Phase 1
A Single and Multiple Ascending Dose Study of JNJ-90858638 in Healthy Participants (Part 1 and 2: Single and Multiple Ascending Dose)
Autoimmune Diseases
Janssen Research & Development, LLC120 enrolled1 locationACTRN12625001434482
Recruiting
Phase 1
A Study of LUCAR-G79 in Subjects With Relapsed/Refractory Autoimmune Diseases
Relapsed/Refractory Autoimmune Diseases
Nanjing Legend Biotech Co.42 enrolled6 locationsNCT07049081
Recruiting
Phase 1
GT719 Injection for Recurrent/Refractory Antibody-mediated Neurological Immune Diseases
Neurological Autoimmune Diseases
Grit Biotechnology30 enrolled1 locationNCT07021209
Recruiting
Phase 1
An Exploratory Clinical Study of CD19 CAR NK Cell Injection for the Treatment of Relapsed/Refractory Autoimmune Diseases
Autoimmune Diseases
Changhai Hospital72 enrolled1 locationNCT06464679
Recruiting
Phase 1
A Randomized, Double-blind, Placebo-controlled, Dose-escalation Phase 1 Clinical Tiral in Healthy Male Volunteers
Autoimmune Diseases
Daewoong Pharmaceutical Co. LTD.76 enrolled1 locationNCT06736587
Recruiting
Phase 1Phase 2
Sequential CAR-T Cells Targeting BCMA/CD19 in Patients With Relapsed/ Refractory Autoimmune Diseases
Systemic Lupus ErythematosusSjogren's SyndromeAutoimmune Diseases+1 more
Essen Biotech60 enrolled1 locationNCT06428188
Recruiting
Phase 1Phase 2
Fourth-gen CAR T Cells Targeting BCMA/CD19 for Refractory Systemic Lupus Erythematosus (SLE)
Systemic Lupus ErythematosusAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisSjogren's Syndrome+6 more
Essen Biotech75 enrolled1 locationNCT06350110
Recruiting
Phase 1Phase 2
An Open-Label, FIH Study Evaluating the Safety, Tolerability, and Efficacy of VCTX211 Combination Product in Subjects With T1D
Diabetes MellitusMetabolic DiseaseDiabetes Mellitus, Type 1+4 more
CRISPR Therapeutics AG40 enrolled2 locationsNCT05565248
Suspended
Phase 1
A randomized, double-blind, placebo-controlled study of the safety, tolerability, pharmacokinetics and pharmacodynamics of ascending single and multiple doses of SAR446422 in healthy, adult participants
Severe Autoimmune Disease
Sanofi-Aventis Australia Pty Ltd120 enrolled1 locationACTRN12623001176651
Recruiting
Phase 1Phase 2
CAR-T Cells Targeting Autoimmune Diseases
Autoimmune Diseases
Shenzhen Geno-Immune Medical Institute30 enrolled2 locationsNCT05459870