Phase 3 Brain Clinical Trials
70 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–20 of 70 trials
Recruiting
Phase 3
Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors
Malignant Solid NeoplasmMetastatic Malignant Neoplasm in the Brain
Mayo Clinic140 enrolled4 locationsNCT03750227
Recruiting
Phase 2Phase 3
A Study of Buntanetap in Participants With PD
Deep Brain StimulationParkinson's Disease (PD)
Annovis Bio Inc.500 enrolled27 locationsNCT07284784
Recruiting
Phase 3
Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases
Brain Metastases
Canadian Cancer Trials Group206 enrolled86 locationsNCT03550391
Recruiting
Phase 3
Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM
Brain CancerGlioblastomaGBM+4 more
Northwell Health432 enrolled1 locationNCT05271240
Recruiting
Phase 3
Levetiracetam for Seizure Prevention After Brain Tumor Surgery
Postoperative Seizures After Brain Tumor Surgery
Beijing Tiantan Hospital558 enrolled1 locationNCT07239115
Recruiting
Phase 2Phase 3
Minocycline After Successful Endovascular Thrombectomy Recanalization in Acute Anterior Circulation Large Vessel Occlusion (ATTRACTION-MINOA)
Acute Ischemic StrokeMinocyclineAnterior Circulation Brain Infarction+2 more
Xiang Luo860 enrolled1 locationNCT07594314
Recruiting
Phase 3
Emergent Large Vessel Occlusion Endovascular Rescue Therapy With Underlying Intracranial Stenosis
Acute Ischemic StrokeBrain StrokeStenting Treatment
ProMedica Health System342 enrolled1 locationNCT07356284
Recruiting
Phase 3
Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)
Mild Traumatic Brain InjuryAdult Growth Hormone Deficiency
VA Office of Research and Development172 enrolled17 locationsNCT04867317
Recruiting
Phase 2Phase 3
Post-thrombectomy Intra-arterial Tenecteplase for Acute manaGement of Non-retrievable Thrombus and No-reflow in Emergent Stroke
Central Nervous System DiseasesCerebrovascular DisordersIschemic Stroke, Acute+1 more
University of Melbourne462 enrolled12 locationsNCT05892510
Recruiting
Phase 3
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Lung Non-Small Cell Carcinoma+7 more
NRG Oncology269 enrolled263 locationsNCT06500455
Recruiting
Phase 3
Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability
Stage IV Lung Cancer AJCC v8Metastatic Malignant Neoplasm in the BrainMetastatic Lung Small Cell Carcinoma+1 more
NRG Oncology200 enrolled227 locationsNCT04804644
Recruiting
Phase 3
Efficacy of Early Continuous Infusion of HSS on the Neurological Outcome at 6 Months in TBI Patients.
TBI (Traumatic Brain Injury)
Nantes University Hospital760 enrolled23 locationsNCT07319208
Recruiting
Phase 3
Methylphenidate in Pediatric Brain Tumor Survivors With Cancer-related Fatigue
Cancer-related FatigueBrain Tumor, PediatricMethylphenidate
Odense University Hospital50 enrolled4 locationsNCT06905587
Recruiting
Phase 3
Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets
Non-small Cell Lung CancerBrain Tumor
InSightec30 enrolled10 locationsNCT05317858
Recruiting
Phase 3
Efficacy and Safety of Tenecteplase Bridging Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke
Stroke, IschemicDrug EffectStroke, Acute+1 more
Xuanwu Hospital, Beijing850 enrolled1 locationNCT06658197
Recruiting
Phase 3
A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients
NeoplasmsBrain TumorGlioblastoma+5 more
NaviFUS Corporation32 enrolled2 locationsNCT06496971
Recruiting
Phase 3
Bevacizumab Plus FSRT Versus Hippocampus-Avoidant WBRT in Lung Adenocarcinoma With Extensive Brain Metastases
Brain MetastasesLung AdenocarcinomaWhole-Brain Radiotherapy+2 more
Sun Yat-sen University220 enrolled3 locationsNCT07481786
Recruiting
Phase 3
A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma
Brain TumorGlioblastomaGBM+1 more
Ivy Brain Tumor Center450 enrolled95 locationsNCT06388733
Recruiting
Phase 3
A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)
DementiaBrain DiseasesCentral Nervous System Diseases+6 more
Eli Lilly and Company1,500 enrolled141 locationsNCT05508789
Recruiting
Phase 3
The Effects of Intraoperative Tranexamic Acid on Perioperative Bleeding In Craniotomies
Brain TumorBleeding
Stephen Lownie102 enrolled1 locationNCT06229483