Phase 3 Brain Clinical Trials
62 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–20 of 62 trials
Recruiting
Phase 2Phase 3
A Study of Buntanetap in Participants With PD
Deep Brain StimulationParkinson's Disease (PD)
Annovis Bio Inc.500 enrolled27 locationsNCT07284784
Recruiting
Phase 3
Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability
Stage IV Lung Cancer AJCC v8Metastatic Malignant Neoplasm in the BrainMetastatic Lung Small Cell Carcinoma+1 more
NRG Oncology200 enrolled227 locationsNCT04804644
Recruiting
Phase 3
Methylphenidate in Pediatric Brain Tumor Survivors With Cancer-related Fatigue
Cancer-related FatigueBrain Tumor, PediatricMethylphenidate
Odense University Hospital50 enrolled4 locationsNCT06905587
Recruiting
Phase 3
Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases
Brain Metastases
Canadian Cancer Trials Group206 enrolled86 locationsNCT03550391
Recruiting
Phase 3
Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets
Brain Tumor
InSightec30 enrolled10 locationsNCT05317858
Recruiting
Phase 3
Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)
Mild Traumatic Brain InjuryAdult Growth Hormone Deficiency
VA Office of Research and Development172 enrolled4 locationsNCT04867317
Recruiting
Phase 3
Efficacy and Safety of Tenecteplase Bridging Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke
Stroke, IschemicDrug EffectStroke, Acute+1 more
Xuanwu Hospital, Beijing850 enrolled1 locationNCT06658197
Recruiting
Phase 3
A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients
NeoplasmsBrain TumorGlioblastoma+5 more
NaviFUS Corporation32 enrolled2 locationsNCT06496971
Recruiting
Phase 3
Bevacizumab Plus FSRT Versus Hippocampus-Avoidant WBRT in Lung Adenocarcinoma With Extensive Brain Metastases
Brain MetastasesLung AdenocarcinomaWhole-Brain Radiotherapy+2 more
Sun Yat-sen University220 enrolled3 locationsNCT07481786
Recruiting
Phase 3
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Lung Non-Small Cell Carcinoma+7 more
NRG Oncology269 enrolled263 locationsNCT06500455
Recruiting
Phase 3
A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma
Brain TumorGlioblastomaGBM+1 more
Ivy Brain Tumor Center450 enrolled95 locationsNCT06388733
Recruiting
Phase 3
A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)
DementiaBrain DiseasesCentral Nervous System Diseases+6 more
Eli Lilly and Company1,500 enrolled141 locationsNCT05508789
Recruiting
Phase 3
The Effects of Intraoperative Tranexamic Acid on Perioperative Bleeding In Craniotomies
Brain TumorBleeding
Stephen Lownie102 enrolled1 locationNCT06229483
Recruiting
Phase 3
Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults
Traumatic Brain Injury
London School of Hygiene and Tropical Medicine5,000 enrolled2 locationsNCT04521881
Recruiting
Phase 3
Anlotinib Plus Whole-Brain Radiotherapy for Brain Metastases in SCLC Patients.
Whole-Brain Radiotherapy
Cancer Institute and Hospital, Chinese Academy of Medical Sciences134 enrolled1 locationNCT07443397
Recruiting
Phase 3
Bevacizumab Versus Corticosteroids as First-line Treatment in Patients With Symptomatic Cerebral Radiation Necrosis After Radiation for High-grade Glioma or Brain Metastases
Radiation ToxicityBrain MetastasasesHigh Grade Glioma (III or IV)+4 more
The Netherlands Cancer Institute408 enrolled5 locationsNCT06888817
Recruiting
Phase 3
Anesthesia sTrategy foR Organ Procurement In braiN dEath
Brain-dead Organ Donors
University Hospital, Grenoble270 enrolled1 locationNCT07166991
Recruiting
Phase 3
Short Versus Long-term Levetiracetam in Brain Tumors
SeizuresBrain TumorsAntiepileptics+1 more
Tata Memorial Centre604 enrolled2 locationsNCT06442748
Recruiting
Phase 3
A Study Evaluating Furmonertinib Plus Platinum-based Doublet Chemotherapy Versus Osimertinib in Patients With Epidermal Growth Factor Receptor (EGFR) Sensitizing Mutation-Positive Non-squamous Non-Small Cell Lung Cancer (NSCLC) and Brain Metastases
NSCLC Patients With Brain Metastasis
Allist Pharmaceuticals, Inc.380 enrolled1 locationNCT06970639
Recruiting
Phase 3
18F-DOPA II - PET Imaging Optimization
Neuroendocrine TumorsBrain TumorNeuroblastoma+3 more
University of Alberta800 enrolled1 locationNCT04706910