Brain Clinical Trials

4 recruiting

Frequently Asked Questions

Common questions about Brain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 509 trials

Recruiting
Phase 3

The Effects of Intraoperative Tranexamic Acid on Perioperative Bleeding In Craniotomies

Brain TumorBleeding
Stephen Lownie102 enrolled1 locationNCT06229483
Recruiting
Not Applicable

The Impact of Paramedic Training in Simulation on the Experience of Patients Treated for Malignant Brain Tumors in Neurosurgery (IPSIMANON)

Brain Tumor Adult
University Hospital, Brest250 enrolled11 locationsNCT06962215
Recruiting
Phase 2

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

Central Nervous System DiseasesBrain CancerGlioblastoma Multiforme (GBM)+4 more
Black Diamond Therapeutics, Inc.162 enrolled1 locationNCT07326566
Recruiting

Determining Postoperative Recovery and the Impact of Adverse Events in Neurosurgery Based on Self-reported, App-based Longitudinal Assessment

Brain TumorDisc DiseaseInstabilities Lumbar+1 more
Cantonal Hospital of St. Gallen400 enrolled1 locationNCT06352710
Recruiting
Not Applicable

Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing With Shoulder Pain and Functional Problems Caused by Spasticity and Motor Impairment

Traumatic Brain InjuryStrokeMultiple Sclerosis+5 more
Centre National de Rééducation Fonctionnelle et de Réadaptation50 enrolled1 locationNCT06782464
Recruiting
Not Applicable

Treatment Response Assessment Maps to Delineate Necrosis From Tumor After Stereotactic Radiation in Brain Metastases

Brain Tumor
Brigham and Women's Hospital101 enrolled2 locationsNCT04033497
Recruiting
Phase 2Phase 3

A Study of Buntanetap in Participants With PD

Deep Brain StimulationParkinson's Disease (PD)
Annovis Bio Inc.500 enrolled26 locationsNCT07284784
Recruiting

A Multicenter Pediatric Deep Brain Stimulation Registry

Movement DisordersNeurologic DisorderCerebral Palsy+6 more
Boston Children's Hospital100 enrolled1 locationNCT06585618
Recruiting
Not Applicable

TMS-fNIRS Personalized Dosing

Traumatic Brain InjuryPost Traumatic Stress Disorder
Florida State University60 enrolled1 locationNCT05916417
Recruiting
Not Applicable

Treating Depression on a Day-to-day Basis: Development of a Tool for Physicians Based on a Smartphone Application

Brain DiseasesCentral Nervous System DiseasesDepression+2 more
Centre Hospitalier Charles Perrens, Bordeaux200 enrolled1 locationNCT03678194
Recruiting

Lombard Cohort of Brain Health Services

Alzheimer s DiseaseSubjective Cognitive Decline (SCD)Functional Cognitive Disorder+1 more
University of Milano Bicocca1,000 enrolled5 locationsNCT07457138
Recruiting
Phase 1Phase 2

A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations

CancerBrain Tumor
National Cancer Institute (NCI)96 enrolled1 locationNCT05588141
Recruiting
Not Applicable

CSF and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and CNS Metastases or no CNS Metastases

Brain MetastasasesSolid Tumor MalignanciesLeptomeningeal Disease (LMD)
Sunnybrook Health Sciences Centre60 enrolled1 locationNCT07476781
Recruiting
Not Applicable

Individualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma and Ependymoma

MedulloblastomaEpendymomaEpendymoma of Brain+3 more
University of California, San Francisco74 enrolled8 locationsNCT05057702
Recruiting
Phase 1

Intra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Pediatric Brain Tumors

Pediatric Brain TumorRecurrent Pediatric Brain TumorPediatric Neoplasm
Sabine Mueller, MD, PhD24 enrolled8 locationsNCT05887882
Recruiting
Phase 2

Palbociclib and Pembrolizumab In Central Nervous System Metastases

Metastatic Malignant Neoplasm to BrainRecurrent Brain MetastasesProgressive Brain Metastases
Massachusetts General Hospital45 enrolled2 locationsNCT02896335
Recruiting

Tumor Related Epilepsy

CancerEpilepsyBrain Neoplasm
National Institute of Neurological Disorders and Stroke (NINDS)100 enrolled1 locationNCT02639325
Recruiting

Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Gastroesophageal Cancers

Esophageal CancerGastric CancerBrain Metastases
Blokhin's Russian Cancer Research Center30 enrolled1 locationNCT07464470
Recruiting
Not Applicable

Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer

Breast CancerChemo-brainImpaired Cognition
Massachusetts General Hospital200 enrolled2 locationsNCT02290834
Recruiting
Not Applicable

WBSI Guided Personalized Delivery of TTFields

GBMTumor, BrainGlioma Glioblastoma Multiforme
Abramson Cancer Center at Penn Medicine155 enrolled2 locationsNCT05086497