Brain Clinical Trials

1,124 recruitingLast updated: June 18, 2026

There are 1,124 actively recruiting brain clinical trials across 65 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4, Early Phase 1. Top locations include Boston, Massachusetts, United States, Houston, Texas, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Brain Trials at a Glance

1,124 actively recruiting trials for brain are listed on ClinicalTrialsFinder across 6 cities in 65 countries. The largest study group is Not Applicable with 454 trials, with the heaviest enrollment activity in Boston, Houston, and New York. Lead sponsors running brain studies include M.D. Anderson Cancer Center, Beijing Tiantan Hospital, and VA Office of Research and Development.

Treatments under study

About Brain Clinical Trials

Looking for clinical trials for Brain? There are currently 7 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Brain trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Brain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 1,124 trials

Recruiting
Phase 2

Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

Breast CancerColorectal, CancerLung Cancer+13 more
Brigham and Women's Hospital134 enrolled2 locationsNCT04899908
Recruiting
Phase 2

Study of Radiotherapy Combined With Platinum, Adebrelimab and Bevazumab in the Treatment of TNBC-BM.

TNBC - Triple-Negative Breast CancerBrain Metastasases
Fudan University58 enrolled1 locationNCT07638852
Recruiting
Phase 1Phase 2

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

Brain CancerGBMGlioma+12 more
National Institute of Neurological Disorders and Stroke (NINDS)40 enrolled1 locationNCT07416188
Recruiting

Screening for Social Determinants of Health (SDOH) and Cognitive Function in Individuals With History of Stroke

StrokeBrain DiseaseVascular Diseases+1 more
National Institute of Neurological Disorders and Stroke (NINDS)450 enrolled1 locationNCT06615973
Recruiting
Phase 1Phase 2

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

Colorectal, CancerColorectal CarcinomaNon-small Cell Lung Cancer+29 more
Institut de Recherches Internationales Servier554 enrolled27 locationsNCT05786924
Recruiting
Phase 1

Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT)

PineoblastomaEmbryonal Tumor With Multilayered RosettesEpendymoma+3 more
Children's National Research Institute12 enrolled1 locationNCT06193759
Recruiting
Not Applicable

Cognitive Training in the Virtual Reality Setting With Children Undergoing Radiotherapy for Brain Tumors

Brain Tumor
St. Jude Children's Research Hospital45 enrolled1 locationNCT05947045
Recruiting
Phase 1

Sitagliptin in Recurrent/Progressive Grade 4 Glioma

GlioblastomaGliomaRecurrent Glioblastoma+2 more
Kailin Yang, MD, PhD45 enrolled1 locationNCT07541781
Recruiting

Natural History of Stroke: Cause and Development

Brain DiseaseVascular DiseasesIschemic Attack, Transient+2 more
National Institute of Neurological Disorders and Stroke (NINDS)4,000 enrolled3 locationsNCT00009243
Recruiting

Tumor Related Epilepsy

CancerEpilepsyBrain Neoplasm
National Institute of Neurological Disorders and Stroke (NINDS)100 enrolled1 locationNCT02639325
Recruiting
Not Applicable

Promoting Recovery After Brain Injury Using Focused Ultrasound

Consciousness DisordersDisorders of Consciousness Due to Severe Brain Injury
Massachusetts General Hospital36 enrolled2 locationsNCT07277309
Recruiting
Phase 1

Chronic CED of TPT for Recurrent Malignant Glioma

Brain Tumor, RecurrentMalignant Glioma (WHO Grade III or IV)IDH1/IDH2 Mutation
Jeffrey N. Bruce6 enrolled1 locationNCT06666712
Recruiting
Phase 2

Dabrafenib and Trametinib for BRAF V600 Mutant Low-Grade Gliomas

BRAF V600 MutationLow-grade GliomaLow Grade Glioma of Brain+1 more
University of California, San Francisco96 enrolled7 locationsNCT07110246
Recruiting
Phase 3

Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors

Malignant Solid NeoplasmMetastatic Malignant Neoplasm in the Brain
Mayo Clinic140 enrolled4 locationsNCT03750227
Recruiting

Socio-Cultural Level, Health Literacy, and Parental CT Demand in Paediatric Minor Head Trauma: A Prospective Cohort Study

Brain Injuries, TraumaticHead Injuries, ClosedCraniocerebral Trauma
Bursa Yuksek Ihtisas Training and Research Hospital200 enrolled1 locationNCT07655310
Recruiting
Phase 2

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

Central Nervous System DiseasesBrain CancerGlioblastoma Multiforme (GBM)+4 more
Black Diamond Therapeutics, Inc.162 enrolled13 locationsNCT07326566
Recruiting

Top-Down Attentional Control of Visual-Processing

fMRIFocal Brain LesionFocal Lesions
National Institute of Mental Health (NIMH)300 enrolled1 locationNCT01087281
Recruiting
Phase 2Phase 3

A Study of Buntanetap in Participants With PD

Deep Brain StimulationParkinson's Disease (PD)
Annovis Bio Inc.500 enrolled27 locationsNCT07284784
Recruiting
Phase 1

Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain Tumors

Resectable Brain NeoplasmRecurrent Diffuse Hemispheric Glioma, H3 G34-MutantRecurrent Malignant Brain Neoplasm
University of Michigan Rogel Cancer Center11 enrolled1 locationNCT06914479
Recruiting
Not Applicable

Clinical Trial Comparing the Efficacy of Two Teletherapy Programs at Improving Psychological Health in People With Brain Injury

AlexithymiaMild Traumatic Brain Injury
Hackensack Meridian Health300 enrolled3 locationsNCT07436754