Phase 1 Cardiomyopathy Clinical Trials
18 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–18 of 18 trials
Recruiting
Phase 1
A Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated Cardiomyopathy
Dilated Cardiomyopathy (DCM)
Rocket Pharmaceuticals Inc.8 enrolled3 locationsNCT07137338
Recruiting
Phase 1
A Bioequivalence Study of Two Formulations of HRS-1893 Tablets in Healthy Participants
Cardiomyopathy
Shandong Suncadia Medicine Co., Ltd.36 enrolled1 locationNCT07479641
Recruiting
Phase 1
A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediated Arrhythmogenic Cardiomyopathy (PKP2-ACM)
PKP2 Arrhythmogenic Cardiomyopathy (PKP2-ACM)
Rocket Pharmaceuticals Inc.9 enrolled3 locationsNCT05885412
Recruiting
Phase 1
A Research Study to Look at the Distribution and Effects of Coramitug on Amyloid Deposits in Heart Tissue Using PET/CT Imaging in People With ATTR Amyloidosis.
Transthyretin Amyloid Cardiomyopathy
Novo Nordisk A/S14 enrolled1 locationNCT07448623
Recruiting
Phase 1
A Study of AZD4063 in PLN R14del Dilated Cardiomyopathy
Dilated Cardiomyopathy
AstraZeneca31 enrolled4 locationsNCT07241104
Recruiting
Phase 1Phase 2
Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM
Hypertrophic Cardiomyopathy
Tenaya Therapeutics30 enrolled10 locationsNCT05836259
Recruiting
Phase 1Phase 2
Application of [68Ga]Ga-NI-FAPI-04 PET/CT Imaging in Fibroblast Activation Protein Related Diseases
TumorCardiovascular DiseasesPulmonary Fibrosis+3 more
Peking Union Medical College Hospital30 enrolled1 locationNCT07464132
Recruiting
Phase 1Phase 2
ALXN2350 in Adult Participants With BAG3-Associated Dilated Cardiomyopathy
BAG3 Mutation Associated Dilated Cardiomyopathy
Alexion Pharmaceuticals, Inc.6 enrolled7 locationsNCT07218887
Recruiting
Phase 1Phase 2
A Phase I/II Clinical Trial of Intramyocardial Injection of HucMSCs for the Treatment of Chronic Heart Failure
Chronic Heart FailureCoronary Artery Bypass Grafting (CABG)Chronic Ischemic Cardiomyopathy
Tasly Pharmaceutical Group Co., Ltd51 enrolled4 locationsNCT07265349
Recruiting
Phase 1
Donor Bone Marrow Derived Mesenchymal Stem Cells in Controlling Heart Failure in Patients With Cardiomyopathy Caused by Anthracyclines
Heart FailureMalignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm+1 more
M.D. Anderson Cancer Center72 enrolled1 locationNCT02962661
Recruiting
Phase 1
A Phase I Trial on the Relative Bioavailability and Food Effect of HRS-1893 Tablets in Healthy Subjects
Cardiomyopathy
Shandong Suncadia Medicine Co., Ltd.38 enrolled1 locationNCT07272330
Recruiting
Phase 1
A Phase 1 Open-Label Study of the Safety of Intravenous Allogeneic Neonatal Mesenchymal Cells (nMSCs) in Young Adult (1A) and Pediatric (1B) Patients With Dilated Cardiomyopathy (DCM)
Dilated Cardiomyopathy
Emory University36 enrolled5 locationsNCT06464588
Recruiting
Phase 1Phase 2
Genistein in trAnSthyretin recePtor Amyloid caRdiomyopathy
Amyloid Cardiomyopathy
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's20 enrolled1 locationNCT06634108
Recruiting
Phase 1
Modulation of SERCA2a of Intra-Myocytic Calcium Trafficking in Cardiomyopathy Secondary to Duchenne Muscular Dystrophy
DMD-Associated Dilated Cardiomyopathy
Sardocor Corp.12 enrolled3 locationsNCT06224660
Recruiting
Phase 1
Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC
Arrhythmogenic Right Ventricular Cardiomyopathy
Tenaya Therapeutics15 enrolled7 locationsNCT06228924
Recruiting
Phase 1Phase 2
A Phase I/IIa，Open-label, Single Ascending Dose and Dose-expansion Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of YOLT-201 in Patients With Transthyretin Amyloidosis Polyneuropathy (ATTR-PN) or Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM)
Transthyretin Amyloidosis PolyneuropathyTransthyrexin Amyloidosis Cardiomyopathy
YolTech Therapeutics Co., Ltd31 enrolled3 locationsNCT06539208
Recruiting
Phase 1
To Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MYK-224 in Healthy Volunteers
Hypertrophic Cardiomyopathy
MyoKardia, Inc.112 enrolled1 locationACTRN12621000423819
Not Yet Recruiting
Phase 1
Antiarrhythmic effects of phenytoin or dantrolene in patients with cardiomyopathy.
CardiomyopathyArrhythmia
University of Newcastle105 enrolled1 locationACTRN12619000730101