Phase 1 Chemotherapy Clinical Trials
15 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–15 of 15 trials
Recruiting
Phase 1Phase 2
A Phase Ib/II Open-label Study of AMO959 With Lutetium (177Lu) Vipivotide Tetraxetan (AAA617) in Combination With ARPI in Adult Participants With PSMA-positive mCRPC
PSMA-positive Metastatic Castration Resistant Prostate Cancer (mCRPC) With Prior Exposure to One Prior ARPI Who Are Candidates for Taxane-based Chemotherapy
Novartis Pharmaceuticals123 enrolled19 locationsNCT07226986
Recruiting
Phase 1Phase 2
Phase I/II Study of Engineered T Cell Receptor-Modified NK Cells Targeting PRAME in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Myeloid Malignancies
Myeloid MalignanciesLymphodepleting Chemotherapy
M.D. Anderson Cancer Center44 enrolled1 locationNCT06383572
Recruiting
Phase 1
CBG/CBD Oil for Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy Induced Peripheral Neuropathy
Milton S. Hershey Medical Center12 enrolled1 locationNCT07016971
Recruiting
Phase 1Phase 2
Ramucirumab (Cyramza), Nal-IRI (ONIVYDE) and Trifluridine/Tipiracil (Lonsurf) in Second Line Metastatic Gastric Cancer .
ChemotherapyMetastatic Gastric AdenocarcinomaSecond Line
National Health Research Institutes, Taiwan45 enrolled1 locationNCT05927857
Recruiting
Phase 1Phase 2
Hypofractionated Radiotherapy Combined With Immunochemotherapy for Conversion Treatment of Gastroesophageal Junction Adenocarcinoma
ChemotherapyGastroesophageal Junction AdenocarcinomaImmunotherapy+1 more
West China Hospital88 enrolled4 locationsNCT07072351
Recruiting
Phase 1
Randomized Trial of Glutathione With Anti-PD-1 and Chemotherapy in Advanced NSCLC
ChemotherapyNon-small Cell Lung CancerPD1 Antibody+1 more
The First Affiliated Hospital of Zhengzhou University80 enrolled1 locationNCT06896422
Recruiting
Phase 1Phase 2
Induction Toripalimab and Chemotherapy in Locally Advanced Cervical Cancer
Cervical CancerImmunotherapyInduction Chemotherapy
Tianjin Medical University Cancer Institute and Hospital20 enrolled1 locationNCT06093438
Recruiting
Phase 1
Study of IBI363 in Patients with Advanced First-line Gastric Cancer
IBI363 + Chemotherapy
Xiangdong Cheng40 enrolled1 locationNCT06610799
Recruiting
Phase 1Phase 2
EGCG for the Prevention and Treatment of TIPN
Chemotherapy Induced Peripheral Neuropathy
Han Xi Zhao36 enrolled1 locationNCT06524609
Recruiting
Phase 1
OPC5: Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) in Patients With Malignant Pleural Effusion.
Pleural CarcinomatosisQuality of LifeChemotherapy Effect+4 more
Odense University Hospital20 enrolled1 locationNCT06421610
Recruiting
Phase 1
Precision Therapy for Solid Tumors: Synergistic CDK4/6 Inhibition and Anti-VEGF Targeting LncRNA
Breast CancerColorectal, CancerOvarian Cancer+7 more
Lebanese University50 enrolled2 locationsNCT06307249
Recruiting
Phase 1Phase 2
The Efficacy of JS001 Combined With Chemotherapy in Patients With Locally Advanced Colon Cancer
Chemotherapy EffectColonic Neoplasms
Xiangya Hospital of Central South University40 enrolled1 locationNCT03985891
Completed
Phase 1
A randomised, open label study to compare the bioavailability of 12mg (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid capsules against the innovator 10mg (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid capsules conducted under fasting condition in healthy male volunteers.
Tretinoin capsules are indicated for the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant), characterized by the presence of the t(15;17) translocation and/or the presence of the PML/RARa gene who are refractory to, or who have relapsed from, anthracycline chemotherapy, or for whom anthracycline-based chemotherapy is contraindicated. Tretinoin is for the induction of remission only.
Zenith Technology Corporation Limited18 enrolled1 locationACTRN12620000287932
Terminated
Phase 1
A pilot 2-way crossover pharmacokinetic (PK) study (Part A) followed by a pivotal 2-way crossover PK study to assess bioequivalence (Part B) between a test and reference intravenous formulations of 150 mg Fosaprepitant
prevention of nausea and vomiting caused by Chemotherapy
Nevakar Inc56 enrolled1 locationACTRN12619000189123
Not Yet Recruiting
Phase 1
Pharmacokinetics and Safety of Solid Oral Posaconazole(SCH 56592) in Subjects at High Risk for Invasive Fungal Infections
High Risk for Invasive Fungal Infection due to:
- Hematopoietic stem cell transplant (HSCT) recipients undergoing treatment for graft-versus-host disease (GVHD)High Risk for Invasive Fungal Infection due to:
- Expected neutropenia (low white blood cell count) due to chemotherapy for Acute Myelogenous Leukaemia (AML) or Myelodysplastic Syndrome (MDS)
Schering-Plough Pty limited160 enrolled1 locationACTRN12611000364976