Phase 1 Children Clinical Trials
21 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 21 trials
Recruiting
Phase 1Phase 2
Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children
Mechanical VentilationCongenital Heart DiseaseChildren+8 more
Charite University, Berlin, Germany80 enrolled1 locationNCT07193719
Recruiting
Phase 1Phase 2
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
Type 1 DiabetesType 1 Diabetes MellitusType 1 Diabetes Mellitis+7 more
COUR Pharmaceutical Development Company, Inc.72 enrolled31 locationsNCT06783309
Recruiting
Phase 1
Tegavivint With Gemcitabine in Patients With Relapsed or Refractory Osteosarcoma
Refractory OsteosarcomaOsteosarcoma in ChildrenOsteosarcoma Recurrent+1 more
Emory University24 enrolled1 locationNCT07144254
Recruiting
Phase 1Phase 2
Tolerance Results and Immune Mechanisms in Cow´s Milk and/or Hen´s Egg Allergic Children Following Natural Evolution or Oral Immunotherapy
Food Allergy in Children
Fundación de Investigación Biomédica - Hospital Universitario de La Princesa68 enrolled1 locationNCT07419243
Recruiting
Phase 1
A Prospective Trial of Dalbavancin-Based Prophylaxis in Children and Adolescents With High-Risk Leukemia
Acute Myeloid LeukemiaLeukemiaLymphoblastic Leukemia in Children
St. Jude Children's Research Hospital29 enrolled1 locationNCT06810583
Recruiting
Phase 1
Blinatumomab in Refractory Active Childhood Systemic Lupus Erythematosus
Systemic Lupus Erythematosus (SLE)BlinatumomabChildren
Mao Jianhua6 enrolled2 locationsNCT06789107
Recruiting
Phase 1Phase 2
A Phase Ib/II Study to Investigate the Safety of SHR-1819 in Children and Adolescents With Moderate-to-severe Atopic Dermatitis
Children and Adolescents With Moderate-to-severe Atopic Dermatitis
Guangdong Hengrui Pharmaceutical Co., Ltd50 enrolled1 locationNCT06713499
Recruiting
Phase 1
Safety and Efficacy of Systemic Allogenic NK Cells in R/R Neuroblastoma
Neuroblastoma (NB)Neuroblastoma, Recurrent, RefractoryNeuroblastoma in Children
Marzieh Ebrahimi10 enrolled1 locationNCT06674265
Completed
Phase 1
Pivotal in vivo bioequivalence study comparing two formulations of betamethsone OV ointment applied to the skin in healthy male and female volunteers.
Diprosone OV ointment is indicated for the topical treatment of eczema and psoriasis in children and adults.
Zenith Technology Corporation Limited90 enrolled1 locationACTRN12624000621516
Completed
Phase 1
Pivotal in vivo bioequivalence study comparing two formulations of betamethsone ointment applied to the skin in healthy male and female volunteers.
Betamethasone ointment is indicated for the topical treatment of eczema and psoriasis in children and adults.
Zenith Technology Corporation Limited90 enrolled1 locationACTRN12624000107527
Recruiting
Phase 1Phase 2
Thal-Fabs: Reduced Toxicity Conditioning for High Risk Thalassemia
Thalassemia in Children
The Hospital for Sick Children20 enrolled1 locationNCT05426252
Completed
Phase 1
Pivotal in vivo bioequivalence study comparing two formulations of 9-fluoro-11ß-hydroxy- 16ß-methyl-3,20-dioxopregna- 1,4-diene-17,21-diyl dipropanoate cream applied to the skin in healthy male and female volunteers.
9-fluoro-11ß-hydroxy- 16ß-methyl-3,20-dioxopregna- 1,4-diene-17,21-diyl dipropanoate cream is indicated for the topical treatment of eczema and psoriasis in children and adults.
Zenith Technology Corporation Limited90 enrolled1 locationACTRN12623001003662
Recruiting
Phase 1
ALaCART-B: Acute Leukemia and Chimeric Antigen Receptor-T Cell Therapy for B-lymphoblastic Leukemia.
CARLymphoblastic Leukemia in ChildrenLymphoblastic Leukemia+3 more
National University Hospital, Singapore40 enrolled1 locationNCT05038696
Recruiting
Phase 1
CARTALL: Chimeric-Antigen Receptor (CAR) T-Cell Therapy for Relapsed/ Refractory T-Lineage Acute Lymphoblastic Leukaemia
CARRefractory LeukemiaLymphoblastic Leukemia in Children+4 more
National University Hospital, Singapore20 enrolled1 locationNCT05043571
Completed
Phase 1
Pivotal in vivo bioequivalence study comparing two formulations of methylprednisolone aceponate fatty ointment applied to the skin in healthy male and female volunteers.
Methylprednisolone aceponate fatty ointment is indicated for the short term (up to 7 days) treatment of the milder form of eczema, dermatitis and other steroid responsive skin conditions which do not require the use of a more active topical corticosteroid in children and adults.
Zenith Technology Corporation Limited90 enrolled1 locationACTRN12620000160932
Completed
Phase 1
Pilot Study of Assistive Listening Devices in Treating Auditory Processing Deficits in Neurofibromatosis Type 1
auditory processing deficits in children with Neurofibromatosis Type 1
Murdoch Children's Research Institute10 enrolled1 locationACTRN12619000525189
Completed
Phase 1
A Trial Evaluating Safety, Tolerability and Pharmacokinetics of Subcutaneous Single Doses of ACP-015 in Healthy Adult Male Subjects.
AchondroplasiaThanatophoric DysplasiaSkeletal Dysplasia in Children+4 more
Ascendis Pharma Growth Disorders A/S60 enrolled1 locationACTRN12618001157268
Completed
Phase 1
A Phase 2 placebo controlled, double-blind randomised clinical trial assessing the efficacy of a Herbal supplement for Nocturnal Enuresis in Children
Nocturnal enuresis in children
Endeavour College of Natural Health62 enrolled1 locationACTRN12618000288224
Completed
Phase 1
A trial comparing ACP-011 administered as a single dose via a syringe and needle versus an auto-injector
Growth failure in children due to Growth Hormone Deficiency
Ascendis Pharma Endocrinology Division A/S26 enrolled1 locationACTRN12617001471370
Completed
Phase 1
A pilot randomised open-label taste-testing study to evaluate the acceptability of chocolate-based midazolam in children
Children needing a sedating premedication prior to general anaesthesia for a surgical procedure
Princess Margaret Hospital150 enrolled1 locationACTRN12615000225516