Phase 2 Chronic Hepatitis Clinical Trials
27 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 27 trials
Recruiting
Phase 2
A Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg- Negative Adult Subjects With Chronic Hepatitis B (B-SUPREME)
Chronic Hepatitis B Infection
Aligos Therapeutics200 enrolled58 locationsNCT06963710
Recruiting
Phase 1Phase 2
Study of GS-4321 in Healthy Participants and Participants With Chronic Hepatitis Delta Virus
Chronic Hepatitis Delta
Gilead Sciences107 enrolled15 locationsNCT07096193
Recruiting
Phase 2Phase 3
Study to Evaluate Switching to Brelovitug for the Treatment of CHD in Participants Receiving Bulevirtide
Chronic Hepatitis D
Mirum Pharmaceuticals, Inc.120 enrolled22 locationsNCT07454837
Recruiting
Phase 2
A Study of Hydronidone Capsules in Patients With Chronic Hepatitis B Virus-Related Liver Fibrosis
Chronic Hepatitis B-related Liver Fibrosis
Beijing Continent Pharmaceutical Co, Ltd.150 enrolled1 locationNCT07417553
Recruiting
Phase 2
Study of Tenofovir Alafenamide (TAF) in Children and Teen Participants With Chronic Hepatitis B Virus Infection
Chronic Hepatitis B
Gilead Sciences150 enrolled62 locationsNCT02932150
Recruiting
Phase 2
A Study to Evaluate the Safety of Hydronidone Capsules in Patients With Liver Fibrosis
Chronic Hepatitis B With Hepatic Fibrosis
Beijing Continent Pharmaceutical Co, Ltd.200 enrolled1 locationNCT07364448
Recruiting
Phase 2
VIR-2218 and Peginterferon Alfa-2a for Chronic Hepatitis B
Chronic Hepatitis B
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)50 enrolled1 locationNCT06092333
Recruiting
Phase 2
A Study to Evaluate the Antiviral Activity and Immune Response of AHB-137 Injection in Participants With Chronic Hepatitis B (CHB)
Chronic Hepatitis B
Ausper Biopharma Co., Ltd.30 enrolled1 locationNCT06993480
Recruiting
Phase 2
A Multicenter, Randomized, Open, Parallel-designed Study to Evaluate the Efficacy and Safety of HRS-5635 Injection Alone or in Combination With Other Agents in Patients Treated for Chronic Hepatitis B
Chronic Hepatitis B
Fujian Shengdi Pharmaceutical Co., Ltd.369 enrolled1 locationNCT06425341
Recruiting
Phase 2
Intrahepatic and Peripheral Responses to Imdusiran (AB-729) in Chronic Hepatitis B
Chronic Hepatitis B
University of Maryland, Baltimore10 enrolled1 locationNCT06154278
Recruiting
Phase 2
A Study to Evaluate the Efficacy and Safety of Combination Therapy of BRII-179, BRII-835 and PEG-IFNα in Participants With Chronic Hepatitis B Virus (HBV) Infection (ENHANCE)
Chronic Hepatitis B Virus (HBV) Infection
Brii Biosciences Limited250 enrolled14 locationsNCT06650852
Recruiting
Phase 2
A Randomized, Double-blind, Placebo-controlled Phase IIa Clinical Study to Evaluate the Safety and Efficacy of GST-HG131 Tablets in Patients With Chronic Hepatitis B
Chronic Hepatitis B
Fujian Akeylink Biotechnology Co., Ltd.45 enrolled1 locationNCT06263959
Not Yet Recruiting
Phase 2
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of Cavrotolimod in Subjects with Chronic Hepatitis B Infection
Chronic Hepatitis B Infection
Bluejay Therapeutics, Inc90 enrolled6 locationsACTRN12625000173493
Recruiting
Phase 2
A Clinical Trial to Evaluate the Efficacy and Safety of TQA3810 Tablets in Combination/Non Combination With Nucleoside (Acid) Analogues in Patients With Primary/Treated Chronic Hepatitis B
Chronic Hepatitis B
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.90 enrolled6 locationsNCT06566248
Completed
Phase 2
A Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BW-20507 in Healthy Subjects
Chronic Hepatitis B Virus (HBV) Infection
Argo Biopharma Australia Pty Ltd32 enrolled3 locationsACTRN12623000709640
Active
Phase 2
A Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Subjects with Chronic Hepatitis B Virus (HBV) Infection
Chronic Hepatitis B Virus (HBV) Infection
Argo Biopharma Australia Pty Ltd32 enrolled3 locationsACTRN12623000708651
Active
Phase 2
An optional multicenter, open-label Phase 2a multiple dose study in Chronic Hepatitis B (CHB) subjects to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of BJT-778
Chronic Hepatitis B Virus (HBV) Infection
Bluejay Therapeutics Inc.24 enrolled6 locationsACTRN12623000111673
Recruiting
Phase 2
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of BJT-778 in Subjects with Chronic HBV Infection (CHB) and Chronic HDV Infection (CHD).
Chronic Hepatitis D Virus (HDV) InfectionChronic Hepatitis B Virus (HBV) Infection
Bluejay Therapeutics Inc.72 enrolled9 locationsACTRN12623000105640
Completed
Phase 2
Study Investigating the Safety and Immunogenicity of AB-729 and VTP 300 in Virologically Suppressed CHB Participants
Virologically-Suppressed Chronic Hepatitis B
Arbutus Biopharma62 enrolled3 locationsACTRN12622000317796
Completed
Phase 2
A Study to Evaluate the Safety, Tolerability and Antiviral Activity of GS-9688 in Virally-Suppressed Adult Subjects with Chronic Hepatitis B
Chronic Hepatitis B
Gilead Sciences, Inc.50 enrolled2 locationsACTRN12618000143224