Phase 2 Chronic Myeloid Leukemia Clinical Trials
25 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 25 trials
Recruiting
Phase 1Phase 2
Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances
Hodgkin LymphomaMultiple MyelomaAcute Myeloid Leukemia (AML)+7 more
M.D. Anderson Cancer Center80 enrolled1 locationNCT05092451
Recruiting
Phase 1Phase 2
Axatilimab With or Without Azacitidine for the Treatment of Patients With Advanced Phase Myeloproliferative Neoplasms, Myeloproliferative Neoplasm/Myelodysplastic Syndrome Overlap or High Risk Chronic Myelomonocytic Leukemia
Refractory Chronic Myelomonocytic LeukemiaChronic Myelomonocytic LeukemiaMyelodysplastic/Myeloproliferative Neoplasm+5 more
Uma Borate52 enrolled1 locationNCT06523556
Recruiting
Phase 2
CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant
Acute Lymphoblastic LeukemiaAcute Myeloid LeukemiaChronic Lymphocytic Leukemia+7 more
City of Hope Medical Center216 enrolled3 locationsNCT06059391
Recruiting
Phase 2
Phase II Study Assessing Efficacy and Safety of Asciminib in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase.
Chronic Myeloid Leukemia
M.D. Anderson Cancer Center50 enrolled1 locationNCT06236724
Recruiting
Phase 2
Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies
Acute Lymphoblastic LeukemiaAcute Myeloid LeukemiaHodgkin Lymphoma+16 more
Fred Hutchinson Cancer Center60 enrolled1 locationNCT04195633
Recruiting
Phase 1Phase 2
A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies
Acute Lymphoblastic LeukemiaAcute Myeloid LeukemiaAcute Leukemia+8 more
Ossium Health, Inc.12 enrolled9 locationsNCT05589896
Recruiting
Phase 2
Asciminib as Initial Therapy for Patients With Chronic Myeloid Leukemia in Chronic Phase
Leukemia, MyeloidChronic Myeloid Leukemia, Chronic PhaseLeukemia,Myeloid, Chronic+1 more
Augusta University100 enrolled7 locationsNCT05143840
Recruiting
Phase 2
Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Diseases
Hematopoietic and Lymphatic System NeoplasmAcute Lymphoblastic LeukemiaAcute Myeloid Leukemia+7 more
Fred Hutchinson Cancer Center54 enrolled1 locationNCT06013423
Recruiting
Phase 2
Phase II Study Assessing the Efficacy and Toxicity of Olverembatinib Monotherapy in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase
Chronic Myeloid Leukemia
M.D. Anderson Cancer Center50 enrolled1 locationNCT06817720
Recruiting
Phase 1Phase 2
A Phase 1/2 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of TERN-701 in Participants With Chronic Myeloid Leukemia (CARDINAL)
Chronic Myeloid LeukemiaChronic Myeloid Leukemia, Chronic Phase
Terns, Inc.180 enrolled54 locationsNCT06163430
Recruiting
Phase 2
Safety And Efficacy Of TKI Cessation For CML Patients With Stable Molecular Response In A Real World Population
Chronic Myeloid LeukemiaChronic Myeloid Leukemia in RemissionChronic Myeloid Leukemia, BCR/ABL-Positive, in Remission
Baylor College of Medicine100 enrolled4 locationsNCT04626024
Recruiting
Phase 1Phase 2
Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors
Solid TumorsAcute Lymphoblastic LeukemiaAcute Myeloid Leukemia+6 more
Incyte Biosciences International Sàrl70 enrolled25 locationsNCT03934372
Recruiting
Phase 1Phase 2
Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT)
Acute Myeloid LeukemiaMixed Phenotype Acute LeukemiaAcute Lymphoid Leukemia+4 more
University of Florida40 enrolled4 locationsNCT05322850
Recruiting
Phase 2
Optimization of Post-transplantation Benadamustine and Cyclophosphamide in Patients With High-risk Myeloid Malignancies and a Partially Mismatched Donor
Chronic Myeloid LeukemiaAcute Myeloid Leukemia (AML)Myelodysplastic Syndromes (MDS)+2 more
St. Petersburg State Pavlov Medical University60 enrolled1 locationNCT07238712
Recruiting
Phase 2
Two Step Haplo With Radiation Conditioning
Hematopoietic and Lymphatic System NeoplasmAcute Lymphoblastic LeukemiaAcute Myeloid Leukemia+14 more
Thomas Jefferson University63 enrolled1 locationNCT05031897
Recruiting
Phase 2
Open-label Study of Asciminib for CML-CP or CML-AP Patients With T315I Mutation Who Are Resistant, Intolerant or Ineligible to Ponatinib.
Chronic Myeloid Leukemia (CML)
Novartis Pharmaceuticals20 enrolled2 locationsNCT06514534
Recruiting
Phase 2
PEARL Study: PotEntial of Asciminib in the eaRly Treatment of CML
Chronic Myeloid LeukemiaChronic Myeloid Leukemia, Chronic PhaseCML, Chronic Phase+1 more
Gruppo Italiano Malattie EMatologiche dell'Adulto160 enrolled11 locationsNCT06409936
Recruiting
Phase 2
Intensity Modulated Total Marrow Irradiation in Fully Human Leukocyte Antigen (HLA)-Matched and Partially-HLA Mismatched Allogeneic Transplantation Patients With High-Risk Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML), and Myelodysplastic Syndrome (MDS)
Myelodysplastic SyndromesAcute Myeloid Leukemia, RefractoryChronic Myeloid Leukemia - Accelerated Phase+1 more
University of Illinois at Chicago38 enrolled1 locationNCT06802315
Recruiting
Phase 2
Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in Patients With Malignant Diseases
Acute Lymphoblastic LeukemiaAcute Myeloid LeukemiaChronic Myeloid Leukemia+4 more
University of Florida20 enrolled1 locationNCT05800210
Recruiting
Phase 2
Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial
Acute Myeloid LeukemiaChronic Myeloid LeukemiaMyelodysplastic Syndrome+3 more
Imperial College London50 enrolled8 locationsNCT06355583