Early Phase 1 CLE Clinical Trials
40 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 40 trials
Recruiting
Early Phase 1
Project 4: Ambulatory Biofeedback and Voice Therapy for Patients With Vocal Hyperfunction
Voice disordersMuscle Tension DysphoniaVocal Fold Polyp+1 more
Massachusetts General Hospital100 enrolled2 locationsNCT05970562
Recruiting
Early Phase 1
Placebo-controlled Study of Single and Multiple Ascending Doses of UDP-003 in Healthy Human Participants and Followed by an Open-label Patient Cohort
Atherosclerotic Cardiovascular DiseaseAcute Coronary Syndromes
Cyclarity Therapeutics, Inc.84 enrolled1 locationNCT06813339
Recruiting
Early Phase 1
MTS109 in Patients With Refractory Autoimmune Diseases
Systemic Lupus ErythematosusIdiopathic Inflammatory MyopathiesSystemic Sclerosis (SSc)+2 more
Shanghai Changzheng Hospital15 enrolled1 locationNCT07526350
Recruiting
Early Phase 1
The Safety and Efficacy of Allogeneic CD70 CAR-T Therapy in Unresectable or Metastatic Clear Cell Renal Cell Carcinoma
Unresectable or Metastatic Clear Cell Renal Cell Carcinoma
Chinese PLA General Hospital30 enrolled3 locationsNCT07645690
Recruiting
Early Phase 1
Human Umbilical Cord Mesenchymal Stem Cell-derived Small Extracellular Vesicles for the Treatment of Dry Eye Disease
Umbilical Cord Mesenchymal Stem Cell-derived Small Extracellular VesiclesDry-Eye Disease
The First Affiliated Hospital of Xiamen University20 enrolled1 locationNCT07623382
Recruiting
Early Phase 1
This is an Early Exploratory Study to Assess the Tolerability and Safety of GC012F in Patients With Multiple Sclerosis
Multiple Sclerosis
Daishi Tian9 enrolled1 locationNCT07303790
Recruiting
Early Phase 1
Evaluation of an Oral Microbiota-based Therapeutic as a Treatment Option for PSC
Primary Sclerosing Cholangitis
University of Minnesota28 enrolled1 locationNCT06197308
Recruiting
Early Phase 1
CD19/BCMA UCAR-T for B Cell-Related Autoimmune Disease
IgA Nephropathy (IgAN)Autoimmune DiseasesSystemic Sclerosis (SSc)+3 more
The Children's Hospital of Zhejiang University School of Medicine15 enrolled1 locationNCT07586267
Recruiting
Early Phase 1
CD19/BCMA-Targeted UCAR-T for Patients With Neurological Autoimmune Diseases
Relapsing or Refractory Multiple Sclerosis (MS)Myasthenia Gravis (MG)Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)+1 more
Tongji Hospital36 enrolled1 locationNCT07337785
Recruiting
Early Phase 1
Quadriceps Motor Unit Adaptation to Simulated Knee Injury
Muscle InhibitionKnee Injury Simulation
University of Central Florida45 enrolled1 locationNCT06999057
Recruiting
Early Phase 1
A Clinical Study of IMC-001 for Injection in Improving Atherosclerotic Plaque Stability in Patients With Acute Coronary Syndrome.
Atherosclerosis
ImmuneOnco Biopharmaceuticals (Shanghai) Inc.18 enrolled2 locationsNCT06788431
Recruiting
Early Phase 1
A Study of CC312 for Relapsed/Refractory Autoimmune Diseases
SLE - Systemic Lupus ErythematosusSSc-Systemic SclerosisIIM- Idiopathic Inflammatory Myopathies
CytoCares Inc6 enrolled1 locationNCT07193810
Recruiting
Early Phase 1
Allogeneic CD19/BCMA CAR-T for B Cell-Related Autoimmune Disease
IgA Nephropathy (IgAN)Autoimmune DiseasesSystemic Sclerosis (SSc)+3 more
The Children's Hospital of Zhejiang University School of Medicine15 enrolled1 locationNCT07507201
Recruiting
Early Phase 1
TBI Using IMRT and Cyclophosphamide Prior to Stem Cell Transplant for the Treatment of Severe Systemic Sclerosis
Systemic Scleroderma
City of Hope Medical Center15 enrolled1 locationNCT04380831
Recruiting
Early Phase 1
Clinical Study on Targeted CD19 or CD19-BCMA CAR-T Therapy for Autoimmune Diseases
Sjogren's SyndromeAutoimmune DiseasesIdiopathic Inflammatory Myopathies+3 more
Nanjing Bioheng Biotech Co., Ltd.20 enrolled1 locationNCT06548607
Recruiting
Early Phase 1
Statin Therapy in Primary Sclerosing Cholangitis (PSC): a Multi-omics Study
Inflammatory Bowel DiseasesPrimary Sclerosing Cholangitis
Stanford University15 enrolled1 locationNCT05912387
Recruiting
Early Phase 1
Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA U CAR-T Cell Injection for the Treatment of Relapsed/Refractory Autoimmune Diseases
Rheumatoid ArthritisSystemic Lupus ErythematosusAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis+3 more
Changhai Hospital60 enrolled1 locationNCT07246096
Recruiting
Early Phase 1
Effects of Ublituximab on Motor Functions in Multiple Sclerosis
Multiple Sclerosis (MS) - Relapsing-remitting
Georgia State University25 enrolled2 locationsNCT06629428
Recruiting
Early Phase 1
Clinical Study on Targeted CD19/BCMA CAR-T Therapy for Autoimmune Diseases
SLESystemic SclerosisNMOSD+4 more
Nanjing Bioheng Biotech Co., Ltd.18 enrolled1 locationNCT06775912
Recruiting
Early Phase 1
Safety, Efficacy and Cellular Metabolic Dynamics of CT1195E in Patients With Refractory / Progressive SSC
SSc-Systemic Sclerosis
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology12 enrolled1 locationNCT07355972