Early Phase 1 CLE Clinical Trials
38 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 38 trials
Recruiting
Early Phase 1
CD19/BCMA UCAR-T for B Cell-Related Autoimmune Disease
IgA Nephropathy (IgAN)Autoimmune DiseasesSystemic Sclerosis (SSc)+3 more
The Children's Hospital of Zhejiang University School of Medicine15 enrolled1 locationNCT07586267
Recruiting
Early Phase 1
CD19/BCMA-Targeted UCAR-T for Patients With Neurological Autoimmune Diseases
Relapsing or Refractory Multiple Sclerosis (MS)Myasthenia Gravis (MG)Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)+1 more
Tongji Hospital36 enrolled1 locationNCT07337785
Recruiting
Early Phase 1
Quadriceps Motor Unit Adaptation to Simulated Knee Injury
Muscle InhibitionKnee Injury Simulation
University of Central Florida45 enrolled1 locationNCT06999057
Recruiting
Early Phase 1
MTS109 in Patients With Refractory Autoimmune Diseases
Systemic Lupus ErythematosusIdiopathic Inflammatory MyopathiesSystemic Sclerosis (SSc)+2 more
Shanghai Changzheng Hospital15 enrolled1 locationNCT07526350
Recruiting
Early Phase 1
A Clinical Study of IMC-001 for Injection in Improving Atherosclerotic Plaque Stability in Patients With Acute Coronary Syndrome.
Atherosclerosis
ImmuneOnco Biopharmaceuticals (Shanghai) Inc.18 enrolled2 locationsNCT06788431
Recruiting
Early Phase 1
A Study of CC312 for Relapsed/Refractory Autoimmune Diseases
SLE - Systemic Lupus ErythematosusSSc-Systemic SclerosisIIM- Idiopathic Inflammatory Myopathies
CytoCares Inc6 enrolled1 locationNCT07193810
Recruiting
Early Phase 1
Allogeneic CD19/BCMA CAR-T for B Cell-Related Autoimmune Disease
IgA Nephropathy (IgAN)Autoimmune DiseasesSystemic Sclerosis (SSc)+3 more
The Children's Hospital of Zhejiang University School of Medicine15 enrolled1 locationNCT07507201
Recruiting
Early Phase 1
TBI Using IMRT and Cyclophosphamide Prior to Stem Cell Transplant for the Treatment of Severe Systemic Sclerosis
Systemic Scleroderma
City of Hope Medical Center15 enrolled1 locationNCT04380831
Recruiting
Early Phase 1
Clinical Study on Targeted CD19 or CD19-BCMA CAR-T Therapy for Autoimmune Diseases
Sjogren's SyndromeAutoimmune DiseasesIdiopathic Inflammatory Myopathies+3 more
Nanjing Bioheng Biotech Co., Ltd.20 enrolled1 locationNCT06548607
Recruiting
Early Phase 1
Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA U CAR-T Cell Injection for the Treatment of Relapsed/Refractory Autoimmune Diseases
Rheumatoid ArthritisSystemic Lupus ErythematosusAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis+3 more
Changhai Hospital60 enrolled1 locationNCT07246096
Recruiting
Early Phase 1
Statin Therapy in Primary Sclerosing Cholangitis (PSC): a Multi-omics Study
Inflammatory Bowel DiseasesPrimary Sclerosing Cholangitis
Stanford University15 enrolled1 locationNCT05912387
Recruiting
Early Phase 1
Placebo-controlled Study of Single and Multiple Ascending Doses of UDP-003 in Healthy Human Participants and Patients
Atherosclerotic Cardiovascular DiseaseAcute Coronary Syndromes
Cyclarity Therapeutics, Inc.84 enrolled1 locationNCT06813339
Recruiting
Early Phase 1
Effects of Ublituximab on Motor Functions in Multiple Sclerosis
Multiple Sclerosis (MS) - Relapsing-remitting
Georgia State University25 enrolled2 locationsNCT06629428
Recruiting
Early Phase 1
Clinical Study on Targeted CD19/BCMA CAR-T Therapy for Autoimmune Diseases
SLESystemic SclerosisNMOSD+4 more
Nanjing Bioheng Biotech Co., Ltd.18 enrolled1 locationNCT06775912
Recruiting
Early Phase 1
This is an Early Exploratory Study to Assess the Tolerability and Safety of GC012F in Patients With Multiple Sclerosis
Multiple Sclerosis
Daishi Tian15 enrolled1 locationNCT07303790
Recruiting
Early Phase 1
Safety, Efficacy and Cellular Metabolic Dynamics of CT1195E in Patients With Refractory / Progressive SSC
SSc-Systemic Sclerosis
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology12 enrolled1 locationNCT07355972
Recruiting
Early Phase 1
First-in-Human Study for the Safety and Evaluation of Two 4R Tau Ligands as Potential PET Radioligands for Imaging Tau Protein in the Brain
Healthy ParticipantsProgressive Supranuclear Palsy (PSP)
Invicro24 enrolled1 locationNCT07348276
Recruiting
Early Phase 1
Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Johns Hopkins University24 enrolled1 locationNCT06656702
Recruiting
Early Phase 1
Assessment of Synaptic Density in MS
Multiple Sclerosis
Brigham and Women's Hospital30 enrolled1 locationNCT04634994
Recruiting
Early Phase 1
the Safety and Efficacy of Targeted BCMA In Vivo LV Injection for Recurrent or Refractory Autoimmune Diseases
Recurrent or Refractory Systemic Lupus ErythematosusRecurrent or Refractory IgG4 Related DiseasesRecurrent or Refractory Systemic Sclerosis+2 more
Tongji Hospital45 enrolled1 locationNCT07339540