RecruitingEarly Phase 1NCT07303790

This is an Early Exploratory Study to Assess the Tolerability and Safety of GC012F in Patients With Multiple Sclerosis

An Early Exploratory Study to Assess the Tolerability and Safety of GC012F in Patients With Multiple Sclerosis


Sponsor

Daishi Tian

Enrollment

15 participants

Start Date

Jan 16, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This is an early exploratory study to assess the tolerability and safety of GC012F CAR T cell injection in Multiple Sclerosis patients.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is an early-phase safety study of a treatment called GC012F — a type of CAR T-cell therapy — for people with multiple sclerosis (MS). CAR T-cells are immune cells that have been genetically modified to target and remove overactive immune cells that are attacking the nervous system in MS. This is a first-in-human study focused primarily on safety. **You may be eligible if...** - You have been diagnosed with multiple sclerosis - Your blood counts (white blood cells, red blood cells, and platelets) meet specific minimum levels - Your immune protein (IgG) levels are sufficient - You are in good enough health to undergo this experimental treatment **You may NOT be eligible if...** - Your blood counts are too low - You have active serious infections - You are pregnant or breastfeeding - You have other significant health conditions that would make this treatment unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGGC012F CAR-T Cell Injection

A single dose group is planned for the CAR-T cell infusion dose is administrated for each subject.Single IV infusion.


Locations(1)

Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science & Technology

Hubei, Hubei, China

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NCT07303790


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