Entire-body PET Scans for Multiple Sclerosis
Exploratory Study of Entire-body PET Scans for Multiple Sclerosis
Brain Health Alliance
20 participants
Sep 30, 2024
INTERVENTIONAL
Conditions
Summary
To evaluate whether an entire-body positron emission tomography (PET) scanner can be exploited to improve evaluation, monitoring and measurement of both peripheral and central demyelination in multiple sclerosis (MS) patients.
Eligibility
Inclusion Criteria3
- Multiple sclerosis (MS) patients diagnosed by a credentialed neurologist experienced with care of multiple sclerosis patients.
- Normal healthy subjects.
- Willing and able to lie motionless on the PET-CT scanner bed for at least 10 minutes and up to 20 minutes for the duration of the PET-CT medical imaging scan.
Exclusion Criteria6
- Any additional complicating medical illness other than MS including any other neuropsychiatric illness unrelated to MS diagnosed prior to the onset of initial symptoms of MS.
- Pregnancy or breast feeding.
- Diabetes or other metabolic-endocrine disorders.
- Any known concomitant acute infection.
- History of metastatic or locally invasive cancer.
- Recent surgery, chemotherapy or radiation therapy.
Interventions
Entire-body PET-CT scans will be performed with state-of-the-art scanners with different manufacturers' models including Siemens Biograph Vision, United Imaging uEXPLORER and possibly other recently FDA-approved PET-CT scanners.
Amyvid (F18-florbetapir) will be evaluated for binding to white matter of the peripheral and central nervous system of participants
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04390009