Phase 1 CML Clinical Trials
10 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–10 of 10 trials
Recruiting
Phase 1Phase 2
A Phase I/II Study of Trametinib and Azacitidine for Patients With Newly Diagnosed Juvenile Myelomonocytic Leukemia
Neurofibromatosis 1Leukemia, Juvenile MyelomonocyticJMML+2 more
Therapeutic Advances in Childhood Leukemia Consortium58 enrolled19 locationsNCT05849662
Recruiting
Phase 1
UAB 2419-CD34 Selection Using the Automated CliniMACS Prodigy
AMLMyelodysplastic SyndromesCML+3 more
University of Alabama at Birmingham50 enrolled1 locationNCT06047886
Recruiting
Phase 1Phase 2
A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies
Acute Lymphoblastic LeukemiaAcute Myeloid LeukemiaAcute Leukemia+8 more
Ossium Health, Inc.12 enrolled9 locationsNCT05589896
Recruiting
Phase 1
ABL001 + Dasatinib + Prednisone + Blinatumomab in BCR-ABL+ B-ALL or CML
B-cell Acute Lymphoblastic LeukemiaChronic Myeloid Leukemia (CML) in Lymphoid Blast CrisisPhiladelphia Chromosome Positive Acute Lymphoblastic Leukemia Ph+ ALL
Marlise Luskin, MD40 enrolled4 locationsNCT03595917
Recruiting
Phase 1
ELVN-001 for the Treatment of Chronic Myeloid Leukemia With and Without T315I Mutation in Japanese Participants
CML (Chronic Myelogenous Leukemia)Chronic Phase CML
Enliven Therapeutics21 enrolled4 locationsNCT06787144
Recruiting
Phase 1Phase 2
Olverembatinib Combined With Venetoclax and Azacitidine in Blast Phase Ph Chromosome-positive CML
CML,Blast Phase
Institute of Hematology & Blood Diseases Hospital, China29 enrolled1 locationNCT06757855
Completed
Phase 1
A study to evaluate safety, tolerability and pharmacokinetics of ELVN-001 in Normal Healthy Participants- Part B
Parkinson's Disease (PD)Chronic Myeloid Leukaemia (CML)
Enliven Therapeutics, Inc.15 enrolled1 locationACTRN12624000116527
Completed
Phase 1
A study to evaluate safety, tolerability and pharmacokinetics of ELVN-001 in Normal Healthy Participants- Part A
Parkinson's Disease (PD)Chronic Myeloid Leukaemia (CML)
Enliven Therapeutics, Inc.15 enrolled1 locationACTRN12624000115538
Recruiting
Phase 1
A Study of HS-10382 in Patients With Chronic Myeloid Leukemia.
CML, Chronic PhaseCML, Accelerated Phase
Jiangsu Hansoh Pharmaceutical Co., Ltd.108 enrolled1 locationNCT05367700
Terminated
Phase 1
A Phase Ib study of lenalidomide in combination with imatinib for adult patients with chronic myeloid leukaemia in second molecular remission
Chronic Myeloid Leukaemia (CML)
South Australian Health & Medical Research Institute (SAHMRI)20 enrolled1 locationACTRN12615001169538