Phase 1 Condition Clinical Trials
32 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 32 trials
Recruiting
Phase 1Phase 2
A Study of MET233 in Combination With MET097 in Individuals With Obesity or Overweight With or Without Diabetes
Obesity and Obesity-related Medical Conditions
Metsera, a wholly owned subsidiary of Pfizer132 enrolled1 locationNCT06924320
Recruiting
Phase 1Phase 2
PK/PD of Digoxin in Infants With SVHD
Single VentricleInfant ConditionsInfant, Newborn, Diseases+1 more
Duke University20 enrolled2 locationsNCT06613477
Recruiting
Phase 1Phase 2
Modafinil to Improve Fatiguability
Cancer-related Cognitive DifficultiesFatigueCancer-related Problem/Condition
Ottawa Hospital Research Institute40 enrolled1 locationNCT05333250
Recruiting
Phase 1Phase 2
Evaluation of Clinical, Perceived and Instrumental Efficacy of a Scar Gel in Preventing Hypertrophic Scars
hypertrophic scarsSafety and EfficacyTopical Administration+3 more
Herbarium Laboratorio Botanico Ltda80 enrolled2 locationsNCT06751433
Recruiting
Phase 1
Affect of Duavive on Mood & Anxiety Symptoms
MenopauseDepression, AnxietySleep+1 more
St. Joseph's Healthcare Hamilton30 enrolled1 locationNCT04478305
Recruiting
Phase 1
The Effectiveness of Astaxanthin Supplementation on the Clinical Symptoms and Cardio-metabolic Profile in Women with Polycystic Ovary Syndrome
PCO - Polycystic OvariesObesity and Obesity-related Medical Conditions
Isfahan University of Medical Sciences44 enrolled1 locationNCT06642363
Recruiting
Phase 1
A Study to Determine Safety, Tolerability, and Pharmacokinetics of Different Orally Administered Regimens of the Combination ZY19489-Ferroquine in Adult Asymptomatic Plasmodium Falciparum Carriers
uncomplicated malariaAsymptomatic ConditionFalciparum; Malaria
Zydus Lifesciences Limited36 enrolled1 locationNCT05911828
Recruiting
Phase 1
Topical use of Eucalypt sap resin for damaged skin
Inflammatory skin conditions
Integria Healthcare (Australia) Pty Ltd.60 enrolled1 locationACTRN12624000276550
Recruiting
Phase 1
Low Dose Naltrexone for the treatment of long COVID-19
Post COVID-19 Condition
Griffith University56 enrolled1 locationACTRN12623001042639
Completed
Phase 1
Pivotal in vivo bioequivalence study comparing two formulations of 21-acetoxyl group-11 beta-hydroxy-6 Alpha-Methyls-17-propiono Oxy-1,4-pregnen diethylene-3,20-diketone ointment applied to the skin in healthy male and female volunteers.
21-acetoxyl group-11 beta-hydroxy-6 Alpha-Methyls-17-propiono Oxy-1,4-pregnen diethylene-3,20-diketone ointment is indicated for the short term (up to 7 days) treatment of the milder form of eczema, dermatitis and other steroid responsive skin conditions which do not require the use of a more active topical corticosteroid
Zenith Technology Corporation Limited90 enrolled1 locationACTRN12622001421729
Completed
Phase 1
A study of the safety and tolerability of single doses of wafers containing cannabidiol (CBD) that dissolve under the tongue compared to CBD oil that is swallowed in healthy volunteers.
PainInsomniaAnxiety+2 more
iX Biopharma Pty Ltd12 enrolled1 locationACTRN12620000891921
Completed
Phase 1
Pivotal in vivo bioequivalence study comparing two formulations of methylprednisolone aceponate fatty ointment applied to the skin in healthy male and female volunteers.
Methylprednisolone aceponate fatty ointment is indicated for the short term (up to 7 days) treatment of the milder form of eczema, dermatitis and other steroid responsive skin conditions which do not require the use of a more active topical corticosteroid in children and adults.
Zenith Technology Corporation Limited90 enrolled1 locationACTRN12620000160932
Not Yet Recruiting
Phase 1
A Phase 1, Randomised, Double-Blind, placebo controlled, single and multiple ascending dose study to evaluate the safety, tolerability and pharmacokinetics of KZR-616 in healthy female subjects.
Autoimmune disorders for example systemic lupus erythematosusChronic inflammatory conditions for example rheumatoid arthritis
Clinical Netwprk Services72 enrolled1 locationACTRN12618002060224
Completed
Phase 1
Comparative assessment of the absorption of a test formulation of 1 x 10 mg alitretinoin capsule against the innovator 1 x 10 mg alitretinoin capsule conducted under fed conditions in healthy male volunteers.
Bioequivalence study conducted in healthy volunteers comparing a formulation of alitretinoin with no health condition or problem studied.
Although this study is being conducted in healthy volunteers who are not being treated for the condition to which the medicine is used, alitretinoin is a medicine that is used to treat severe chronic eczema that is unresponsive to treatment with potent topical corticosteroids.
Zenith Technology Corp Ltd30 enrolled1 locationACTRN12618000247279
Completed
Phase 1
Comparative assessment of the absorption of a generic formulation of ferrous sulfate/sodium ascorbate modified release tablet against the innovator ferrous sulfate/sodium ascorbate modified release tablet conducted under fasting conditions with diet control in healthy male volunteers
Iron deficiency.
Although this study is being conducted in healthy volunteers who are not being treated for the condition to which the medicine is used, ferrous sulfate and vitamin C is an iron supplement indicated for the prevention and treatment of iron deficiency.
Zenith Technology Corp Ltd24 enrolled1 locationACTRN12618000222246
Completed
Phase 1
Comparative assessment of the absorption of a generic formulation of atorvastatin oral spray against the innovator atorvastatin capsule conducted under fasting conditions in healthy male and female volunteers
Pilot pharmacokinetic study conducted in healthy volunteers comparing two formulations of atorvastatin (oral spray and capsule) with no health condition or problem studied.
Although this study is being conducted in healthy volunteers who are not being treated for the condition to which the medicine is used, atorvastatin is used as an adjunct to diet for the treatment of patients with hypercholesterolaemia.
Zenith Technology Corp Ltd10 enrolled1 locationACTRN12618000208202
Completed
Phase 1
Comparative assessment of the absorption of a generic formulation of phentermine capsule against the innovator phentermine capsule conducted under fed conditions in healthy male and female volunteers in a pilot study
Bioequivalence pilot study conducted in healthy volunteers comparing two formulations of phentermine with no health condition or problem studied.
Although this study is being conducted in healthy volunteers who are not being treated for the condition to which the medicine is used, phentermine is a C5 Controlled Drug indicated in the management of obesity as a short-term adjunct in a medically monitored comprehensive regime of weight reduction.
Zenith Technology Corp Ltd10 enrolled1 locationACTRN12617000172303
Completed
Phase 1
Comparative assessment of the absorption of a generic formulation of voriconazole suspension against the innovator voriconazole suspension conducted under fasting conditions in healthy male and female volunteers
Bioequivalence study conducted in healthy volunteers comparing two formulations of voriconazole with no health condition or problem studied.
Although this study is being conducted in healthy volunteers who are not being treated for the condition to which the medicine is used, voriconazole is a triazole antifungal agent that is used to treat fungal and yeast infections.
Zenith Technology Corporation Limited24 enrolled1 locationACTRN12616001650482
Completed
Phase 1
Comparative assessment of the absorption of a test formulation of 1 x 30 mg alitretinoin capsule against the innovator 1 x 30 mg alitretinoin capsule conducted under fed conditions in healthy male volunteers.
Bioequivalence study conducted in healthy volunteers comparing a formulation of alitretinoin with no health condition or problem studied.
Although this study is being conducted in healthy volunteers who are not being treated for the condition to which the medicine is used, alitretinoin is a medicine that is used to treat severe chronic eczema that is unresponsive to treatment with potent topical corticosteroids.
Zenith Technology Corp Ltd30 enrolled1 locationACTRN12616001221448
Completed
Phase 1
Comparative assessment of the absorption of a generic formulation of Inhaled Insulin against the innovators Humalog KwikPen for injection and the AFREZZA Inhalation Powder Cartridge conducted under fasting conditions in healthy male and female volunteers
Pharmacokinetic and pharmacodynamic study conducted in healthy volunteers comparing three formulations of Insulin with no health condition or problem studied.
Insulin is a medicine that is used to lower blood glucose.
Zenith Technology Corp Ltd18 enrolled1 locationACTRN12615001100583