Affect of Duavive on Mood & Anxiety Symptoms

This study looks at whether a hormone therapy called Duavive (a combination of estrogen and a bone-protective compound) can help improve mood and reduce anxiety in women going through perimenopause or early menopause who are experiencing depression or anxiety symptoms. **You may be eligible if...** - You are a woman between 45 and 60 years old - You are in perimenopause or within 10 years of your last menstrual period - You are experiencing symptoms of depression and/or anxiety - You can communicate in English **You may NOT be eligible if...** - You have a history of breast, ovarian, or endometrial cancer - You have unexplained abnormal uterine bleeding - You have had a blood clot, stroke, or heart attack - You have active liver disease - You have a known blood clotting disorder Talk to your doctor to see if this trial is right for you.