Phase 1 Diseases Clinical Trials
108 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 108 trials
Recruiting
Phase 1
Diagnosis of Pheochromocytoma
PheochromocytomaEndocrine DiseaseEndocrine Diseases
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)3,000 enrolled1 locationNCT00004847
Recruiting
Phase 1
A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases
Refractory Autoimmune Diseases
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company125 enrolled28 locationsNCT07115745
Recruiting
Phase 1
A Study to Evaluate the Safety of BG-A3004 in Healthy Participants and Patients With Immune-Mediated Skin Diseases
Skin Diseases
BeOne Medicines98 enrolled5 locationsNCT07412691
Recruiting
Phase 1
The BCMA/CD19 Dual Targeted CAR-T Cell in Participants With Autoimmune Kidney Diseases
ANCA-associated VasculitisIgG4-Related DiseasesLupus Nephritis+1 more
Nanjing University School of Medicine24 enrolled1 locationNCT06285279
Recruiting
Phase 1Phase 2
CAR-T Cells Targeting Autoimmune Diseases
Autoimmune Diseases
Shenzhen Geno-Immune Medical Institute30 enrolled1 locationNCT05459870
Recruiting
Phase 1Phase 2
Autoimmune Disease Treatment With Mesenchymal Stem Cells (MSCs) and CAR-T Cells
Autoimmune Diseases
Shenzhen Geno-Immune Medical Institute30 enrolled1 locationNCT06435897
Recruiting
Phase 1
A Study to Assess the Safety and Pharmacokinetics of INCB123667 When Administered Orally to Adult Participants With Moderate or Severe Hepatic Impairment
Liver DiseasesHepatic Insufficiency
Incyte Corporation16 enrolled4 locationsNCT07559474
Recruiting
Phase 1Phase 2
A Study of YL201 in Combination With Other Anti-Cancer Therapies in Patients With Advanced Solid Tumors
Thoracic Neoplasms, Lung Diseases, Small Cell Lung Carcinoma
MediLink Therapeutics (Suzhou) Co., Ltd.118 enrolled22 locationsNCT07407933
Recruiting
Phase 1
Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy
Multiple SclerosisProgressive Multifocal LeukoencephalopathyOther Neuroinflammatory Diseases With BBB Leakage
National Institute of Neurological Disorders and Stroke (NINDS)15 enrolled1 locationNCT05849467
Recruiting
Phase 1
Safety and Feasibility Study of Autologous Engineered Urethral Constructs for the Treatment of Strictures
Male Urogenital DiseasesUrologic DiseasesUrethral Stricture+1 more
Wake Forest University Health Sciences10 enrolled2 locationsNCT03258658
Recruiting
Phase 1Phase 2
Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer
Breast NeoplasmsBreast DiseasesNeoplasms+5 more
Stemline Therapeutics, Inc.73 enrolled86 locationsNCT05386108
Recruiting
Phase 1
Phase 1 Clinical Trial to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of DWP212525 in Healthy Volunteers
Autoimmune Diseases
Daewoong Pharmaceutical Co. LTD.84 enrolled1 locationNCT06736587
Recruiting
Phase 1
Fecal Microbiota Transplantation in an Expanded Ulcerative Colitis Population
Inflammatory Bowel DiseasesUlcerative ColitisClostridioides Difficile Infection
University of Alberta85 enrolled2 locationsNCT07401680
Recruiting
Phase 1
Study of S-4321 in Participants With an Autoimmune or Immune-mediated Disease
Psoriatic Arthritis (PsA)Rheumatoid Arthritis (RA)Psoriasis (PsO)+3 more
Seismic Therapeutic AU Pty Ltd24 enrolled2 locationsNCT07455578
Recruiting
Phase 1
HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors
NeoplasmsNeoplasms by SiteBrain Diseases+30 more
M.D. Anderson Cancer Center24 enrolled3 locationsNCT03911388
Recruiting
Phase 1Phase 2
Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection
Prostate CancerMetastatic Castration-resistant Prostate CancerUrogenital Neoplasms+3 more
Blue Earth Therapeutics Ltd82 enrolled21 locationsNCT05413850
Recruiting
Phase 1Phase 2
ADSCs Therapy in Patients With CTD-ILD
Interstitial Lung DiseaseConnective Tissue Diseases
China Medical University Hospital16 enrolled1 locationNCT06574581
Recruiting
Phase 1
FES Cycling With BFR in the Spinal Cord Injury Population
Spinal Cord InjuryMetabolic Diseases, Type 2 Diabetes, Cardiovascular DiseaseCardio Vascular Disease
Dr. B. Catharine. Craven6 enrolled1 locationNCT07588503
Recruiting
Phase 1
Clinical Trial of TQH3906 Capsules for the Treatment of Adult Patients With Moderately to Severely Active Ulcerative Colitis or Crohn's Disease
Inflammatory Bowel Diseases
Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.135 enrolled30 locationsNCT06754891
Recruiting
Phase 1Phase 2
Human Immune Response to Ixodes Scapularis Tick Bites
Lyme DiseaseTick-Borne DiseasesTick Resistance
National Institute of Allergy and Infectious Diseases (NIAID)60 enrolled1 locationNCT05036707